Bone Abstracts

Background: The activation of Wnt/β-catenin signaling promotes cellular senescence and induces matrix metalloproteinases (MMPs) expression in intervertebral disc (IVD). However, little is known about the effects of hyperbaric oxygen (HBO) on the Wnt/β-catenin signaling and MMPs expression in degenerated human IVDs.Materials and methods: Nucleus pulposus cells (NPCs) were separated from the degenerated disc nucleus tissue by performing sequentia...

Background: Expression of toll-like receptor (TLR) 2 and 4 was up-regulated in lesional areas of OA cartilage. Hyperbaric oxygen (HBO) reduces the TLR signalling pathway in multiple organ failures. However, little is known about the effects of HBO on the catabolic pathway mediated by TLRs in human osteoarthritic (OA) chondrocytes.Materials and methods: OA chondrocytes were separated from the knees of OA patients by performing sequential enzymatic digesti...

Objective: We constructed height growth curves for children with XLH from birth to early adolescence, a majority of whom received conventional therapy consisting of multiple daily doses of oral phosphate and active vitamin D.Methods: Growth data from four clinical studies were pooled to construct the growth curves. UX023-CL002 was an observational, retrospective chart review of 103 children with XLH, 1–14 years of age. Pre-treatment data were collec...

Objective: To explore the characterization and risk factors of acute-phase response (APR) following a first-dose administration of 5 mg zoledronic acid for treatment of osteoporosis.Method: We conducted clinical data of the zoledronic acid users for treatment of osteoporosis in Department of Endocrinology, West China Hospital, Sichuan University from January 2009 to November 2012.Results: A total of 178 patients were eligible for i...

Aim & background: Evidence from genetic studies of osteoporosis and fracture risk indicate that bone mineral density (BMD) is genetically controlled. The low-density-lipoprotein-related receptor 5 (lrp5) gene is a known co-receptor in the canonical Wnt bone formation regulatory pathway. Although mutations found in this gene have been shown to regulate BMD in humans, and Lrp5 knockout mice had reduced bone mass, its role in the bone development/bone acquis...

Purpose: To study the value of the central vertebral height restoration by kyphoplasty for treatment of biconcave vertebral compression fractures.Method: Review the patients with the single biconcave vertebral compression fracture receiving kyphoplasty treatment from 2006 to 2013 (49 cases, 13 males and 36 females) According to Genant classification, with the central vertebral compression ratio, they are divided into type II (<25%, 11 cases), type II...

Background: Surgical and conservative treatments are both crucial method to deal with osteoporotic fracture, anti-osteoporotic therapy is the most important among conservative treatments and diphosphonate medicine is the first-line choice. The pharmacological action of diphosphonate medicine is to inhibit the function of osteoclast, so there is no consensus if it will inhibit porosis and union of fracture.Purpose: To find out the influence of diphosphona...

Indoxyl sulfate (IS) is one of a number of protein-bound uremic toxins that accumulate in patients with chronic kidney disease. Current conventional hemodialysis is ineffective at removing this toxin. Although IS may impair osteoblast function and induce abnormalities of bone turnover or arthropathy, the effects on knee joint tissue by IS has not been investigated yet. The present studies have been carried out to test the IS effects on synovial fibroblasts, meniscal fibrochond...

Odanacatib (ODN), a selective and reversible cathepsin K inhibitor was shown to histomorphometrically reduce trabecular (Tb) and intracortical (Ic) bone remodeling while preserving endocortical (Ec) and stimulating periosteal (Ps) bone formation (BF) in monkeys. Here, we investigate the bone site specific mechanism of ODN on bone modeling (Mo) versus remodeling (Re)-based osteons. Rhesus monkeys (13–19 yrs, n=8–11/group) were ovariectomized and treated with ...

The selective cathepsin K inhibitor odanacatib (ODN) is currently in development for the treatment of postmenopausal osteoporosis. Our goal was to evaluate the effects of ODN vs alendronate (ALN) on bone mass and strength of lumbar vertebrae (LV) in orchiectomized (ORX) rabbits, a model of male osteoporosis. Adult male rabbits (11 months old) were subjected to sham- (n=20) or ORX-surgery (n=24/group) for 7.5 months before dosing initiated. ORX animals were ra...