Bone Abstracts

The study is aimed to evaluate body composition and bone status in adult patients with active juvenile idiopathic arthritis (JIA) untreated with tumor necrosis factor α inhibitors. Adult patients (12 males and 19 females) with JIA and 84 healthy age- and gender- matched controls were enrolled into the study. Body composition and areal bone mineral density (aBMD) at the lumbar spine, proximal femur, femoral neck, distal radius and total body were assessed using dual energy...

Objective: To find whether treatment with cholecalciferol and calcium in a group of vitamin D deficient women is associated with changes in muscular function, musculoskeletal pain, and fatigue.Design: Prospective interventional cohort study.Sample: A study group of 25 post partum women recruited and diagnosed with hypovitaminosis D during pregnancy.Setting: The study group was recruited 2006–2009 at two ...

Objectives: Increased fracture risk and decreased bone mineral density (BMD) have been demonstrated by several studies in Turner syndrome (TS). Affected females have short stature and present with primary amenorrhea. Good densitometric predictor of fractures and longitudinal data on BMD development in childhood and adolescence are still lacking.Patients and methods: Single tertiary care endocrinology center longitudinal study was performed. Peripheral qu...

Objectives: Turner syndrome (TS) affects 1:2000 girls and is mainly characterised by short stature and ovarian failure. Increased fracture risk has been reported in historical cohorts of women with TS and it was linked to their decreased bone mineral density (BMD). Nowadays, girls with TS are treated with growth hormone and substituted with estrogens, of which role in optimal bone mass accretion has been confirmed. Whether increased fracture rate is still of concern in these p...

To point out common patterns of malalignment and deformity in hypophosphatemic rickets and describe treatment principles and techniques as well as common obstacles.Methods: Deformities of the lower limb in hypophosphatemic rickets do not resolve spontaneously under metabolic control of the disease. To prevent severe deformity and joint overload in the growing child guided growth has been shown to be effective in most cases. As recurrence of malalignment ...

Glucocorticoids (GC) are effective drugs in the treatment of inflammatory diseases, including various forms of arthritis. However, their use is limited by negative effects on bone mass and strength, resulting in increased osteoporotic fractures. Conditional knockout mice demonstrated that the GR in osteoblasts is essential for GC-dependent bone loss. Recent studies show that GC profoundly inhibit Wnt signaling by stimulating the expression of Wnt antagonists such as dickkopf-1...

: Glucocorticoid-induced osteoporosis (GIO) is the most frequent secondary osteoporosis in patients undergoing steroid therapy.Recently we demonstrated that the inhibition of bone formation in GIO is occurring in part via the suppression of autocrine cytokines by the glucocorticoid receptor (GR) monomer in osteoblasts (Cell Metab 11, 517–531). Since emerging evidences indicate that microRNAs (miRNAs) play a critical role in the differentiat...

It is known that body weight is positively correlated with increased bone mineral density and decreased fracture risk. Adiponectin is expressed in bone forming cells, and administration of adiponectin has been demonstrated to stimulated osteoblast proliferation. The overall role of adiponectin in bone metabolism remains unrevealed as both stimulated and inhibiting effects on osteoclastogenesis have been reported. We aimed at describing the relationship between adiponectin and ...

Loss of genomic maintenance contributes to aging, as exemplified by mutations in Ercc DNA repair proteins that lead to a plethora of progeroid syndromes of which some display accelerated bone loss. It is generally accepted that dietary restriction (DR) increases life span and improves organ function. We therefore assessed the impact of DR on life span and bone mass in WT and bona fide prematurely aging hypomorphic Ercc-deficient mice (Ercc1−/Δ).<...

Background: Turner syndrome (TS) is associated with decreased bone mineral density and altered bone geometry, which is assumed a risk factor leading to increased fracture rate. Although hypogonadism or SHOX gene haploinsufficiency are the probable causes, the exact mechanism remains unclarified. Particularly, the muscle function as an important determinant of bone strength has yet not been focused on in TS.Objective: We tested the hypothesis that there i...