Bone Abstracts

see PP360....

Objective: To identify predictors of inadequate response to oral bisphosphonate therapy, defined as the incidence of ≧2 fractures while on treatment among incident oral bisphosphonate users with high refill compliance (≧80%).Material and methods: Data from computerized records and pharmacy invoices were obtained from SIDIAP (Catalonia, E) and Danish Health Registries (DK) for all incident users of oral bisphosphonates in 2006–2007 and 2000&#15...

Maternal vitamin D status has been positively associated with infant bone mass in observational studies. We therefore evaluated whether 1000 IU/day cholecalciferol during pregnancy would lead to greater offspring bone mass at birth, in a UK, multicentre, randomised, double-blind, placebo-controlled trial (MAVIDOS, ISRCTN82927713).At 12 weeks’ gestation, pregnant women with a serum 25-hydroxyvitamin D [25(OH)D] 25-100 nmol/l were randomised to either...

Objectives: Single nucleotide polymorphisms (SNP) in genes related to vitamin D metabolism have been associated with 25-hydroxyvitamin D (25(OH)D) status, but these relationships have not been examined in pregnancy or following antenatal vitamin D supplementation. We assessed whether SNPs in DHCR7 (7-dehydrocholesterol reductase), CYP2R1 (25-hydroxylase), CYP24A1 (24-hydroxylase) and GC (Vitamin D binding protein) were associated with the re...

Although Vitamin D deficiency is the most common form of rickets worldwide, when there is a failure to respond to cholecalciferol, inborn errors of vitamin D metabolism should be considered. We describe two unrelated individuals who presented with early onset rickets characterised by reduced serum levels of 25(OH)D and 1,25(OH)2D, and a deficient response to Vitamin D2/D3 and calcitriol. Case 1: A Caucasian Australian girl with non-consanguineous parents ...

Biographical DetailsM Kassim JavaidAfter completing medical training at Charing Cross and Westminster Medical School, I specialized in adult rheumatology at the Wessex Deanery. During that time, I completed a PhD examining the maternal determinants of intra-uterine bone growth as part of an ARC Clinical Fellowship at the University of Southampton fo...

Two kinds of apatite powder were prepared separately from bovine bones originated from different geographical and ecological areas with different climates, in order to characterize and compare their components, hardness and structures by burning them and heat treating the bone ashes at 850 °C in an air furnace. The black ashes were converted to white and yellow–white powders. X-ray diffraction (XRD) analysis indicate that the white powder was carbonate–hydr...

Bisphosphonates are widely used drugs in the fight against osteoclast-mediated bone loss, including osteoporosis and Paget’s disease of bone. The first generation of these potent drugs such as clodronate, a non nitrogen-containing bisphosphonate, has been shown to inhibit osteoclast formation and osteoclastic bone resorption both in vitro and in vivo as well as inducing apoptotic cell death. Recent interest has centred on the effects of more potent nitro...

Objective: The aim of this study was to evaluate the pulpal responses to octacalcium phosphate (OCP) and calcium hydroxide (CH) used as direct pulp capping (DPC) materials.Study design: The pulp of 72 premolars teeth of nine cats were selected for this experiment. After the cats had been anesthetized, the teeth were exposed and capped directly with OCP, CH, and no capping materials used as control group. The cavities of all three groups were filled with ...

Background and aim: This study was designed to investigate the process of bone formation caused by implantation of octacalcium phosphate (OCP) at alveolar ridge.Materials and methods: In this descriptive study we used 20 male Sprague–Dawley rats. Synthetic OCP was implanted into the bony defect measuring 3 mm in diameter and 2 mm in depth was surgically created with a bur in the rat mandible. Bone formation at the alveolar ridge was examined histolo...