Bone Abstracts

Objective: The reasons for the recent decrease in hip fracture rates remain unclear. While current antiosteoporosis efforts are important also factors earlier in life seem essential and we examined age-period-cohort (APC) effects in hip fracture incidence in the Sweden (SE) and Denmark (DK).Material and Methods: We studied the entire populations aged ≧50 years from 1987 to 2010 in SE and DK and ascertained acute hip fractures in nationwide discharge r...

Study Design: Retrospective study.Purpose: To estimate the usefulness of bone scan and magnetic resonance imaging (MRI) for the diagnosis of new fracture in osteoporotic vertebral fractures.Overview of Literature: The diagnosis of new fracture in osteoporotic vertebral fractures requires simple X-ray and supplementary studies.Methods: We analyzed 87 vertebrae in 44 patients, who diagnosed with osteoporotic ve...

Pradaxa (dabigatran etexilate) is a new anticoagulant, which recently has been approved for clinical use. Dabigatran etexilate (DE) is a direct thrombin inhibitor, which in addition to its effect on blood clotting, may have an anabolic effect on bone. Recently, it has been reported that DE could significantly reduce bone resorption and enhance bone formation resulting in a significant and substantial increase in trabecular bone mass in mice.The aim of th...

Context: Primary hyperparathyroidism (PHPT) in children is thought to be extremely rare. We reviewed our experience with PHPT to better characterize these patients.Objective and methods: A total of 62 patients (<18 years) treated in our hospital were respectively analysed to summarize the clinical characterization and molecular genetics in this rare condition in Chinese. The study was approved by the local Ethics Committee of our center.<p class=...

Wnt signaling is a major regulator of bone metabolism. We recently reported that mutations in WNT1 gene in humans cause early onset osteoporosis and severe osteogenesis imperfecta. To identify the cellular source and the mechanisms causing these severe phenotypes we generated and analyzed global and conditional Wnt1 knockout mice.Heterozygous Wnt1+/− mice were viable and fertile but Wnt1−/− embryos were lost in ute...

Objective: To assess the relationship between thyrotoxicosis and osteoporotic fractures in men and women.Design: Register-based cohort study in patients with a TSH measurement in the region of Funen 1996–2010. All determinations were done in the same lab serving all hospitals and GP practices. Persons with raised TSH or a history of thyroid/pituitary disease were not included.Results: The study population consisted of 222 138 ...

Background: Improving the general population’s vitamin D status through food fortification is part of an ongoing debate. Vitamin D status during pregnancy may influence the long-term bone health of offspring; yet conflicting results have been reported and none of the studies have examined paediatric fracture as outcome.Method: The influence of extra vitamin D exposure during prenatal life and risk of fracture during adolescence was determined by com...

Background: Improving the general population’s vitamin D status through food fortification is part of an ongoing international debate. Vitamin D status during pregnancy may influence the long-term bone health of the offspring; yet conflicting results have been reported and none of the studies have examined paediatric fracture as outcome.Method: The influence of extra vitamin D exposure during prenatal life and risk of fracture during adolescence was...

Objective: It was proved that expansive pedicle screw (EPS) could significantly enhance immediate screw stability through mechanical expanding and compressing. However, there were little researches on growth of bone tissue around screw and dynamic screw stability in vivo in osteoporotic vertebrae. This study was designed to evaluate growth and microstructure of bone tissue around screw and fixation strength of screw in osteoporotic sheep lumbar vertebrae.<p class=...

Objective: The study of melatonin on the levels of autophagy in bone will contribute to new type 2 diabetes osteoporosis-pathological processes by which a specific role and mechanism for the treatment of type 2 diabetes-induced osteoporosis could emerge.Method: This study consists of a two-part experiment. We assessed different body parameters in rats, a type 2 diabetes model application, utilizing different concentrations of melatonin interventions, the...