Bone Abstracts

Introduction: In rheumatoid arthritis (RA) patients subclinical atherosclerosis and cardiovascular events (CV) occur more frequently and at younger ages than in the general population. Previous data suggest that heterogeneous plaques on USA are more unstable and frequently contain a higher amount of lipids and which make them hypoechoic and had higher potential for embolization and thrombosis. The aim of our work was to estimate the prevalence and the ultrasound morphology of ...

The problem of early diagnosis of rheumatoid arthritis remains an important area of research in rheumatology. We investigated changes in bone metabolism, bone mineral density in early rheumatoid arthritis (ERA; up to 12 months). Data were compared with changes in the MRI study of the dominant hand.We observed 24 patients with ERA, the average age – 33.6±5.7 years. The men were 6 (25%), women – 18 (75%). Bone mineral density (BMD) was deter...

Recently, Y1 receptor (Y1R) has arisen as a potential regulator in the local control of bone turnover. BIBP3226 is a potent Y1R selective antagonist that was successfully used in in vitro studies showing a positive impact in the benefit of bone turnover, thus providing good perspectives for its use as a pharmacological tool for bone regeneration.However, BIBP3226 behaviour in a complex milieu such as the bone compartment is unknown. As drugs can...

Introduction: The bone mineral density loss may be related to cancer. A specific correlation in the neuroendocrine tumors (NET) is not fully described yet.Aim: The analyze DXA in patients with or without NET.Material and method: We perfomed central DXA (spine and hip) with a GE Lunar device in post-menopausal women. None of them were previously treated with anti-osteoporotics drugs. The study groups included women with carcinoid tu...

Objectives: To generate pediatric reference values for calcaneal bone mineral density (BMD) in healthy 2–10 years old Swedish children.Methods: Dual energy X-ray absorptiometry (DXA) in combination with a laser measurement of the heel thickness, DXL Calscan (Demetech AB), measures bone mass in the calcaneus and an apparent density (BMAD) is calculated. Healthy, Swedish children were included. The left foot was scanned in 117, 2-year-old; 110, 4-year...

It is well known that the epidermal growth factor receptor (EGFR), its ligands, and the structurally related receptor ERBB2/neu are expressed in skeletal cells. However, the functions of EGFR ligands in bone cells remain poorly defined. In this study, we employed a transgenic mouse line overexpressing the EGFR ligand amphiregulin (AREG) specifically in osteoblasts under the α1(I)-collagen promoter. AREG-tg mice did not show changes in body weight or gross phenotype. Compa...

Objectives: Anorexia nervosa (AN) is a life-threatening eating disorder often associated with reduced bone mass. The aim of the present study was to investigate vitamin D status and the association with BMI, fat mass and bone mineral density (BMD) during a novel intensive nutrition therapy in young AN women.Methods: Twenty-five female AN patients (20.1±2.3 years, BMI 15.5±0.9 kg/m2) admitted to a specialised inpatient eating disorder...

Objectives: The main aim of the study is to describe a new method of quantitative, MRI-based assessment of inflammation in children with chronic recurrent multifocal osteomyelitis (CRMO).General hypothesis: The main hypothesis is that the bone marrow edema, as detected in CRMO with MRI, can be quantified to aid early diagnosis and help identify clinically silent lesions.Methods: We performed a retrospective analysis of static MRI s...

Objective: Hyperthyroidism leads to reduced mineral bone density and is associated with increased risk of fracture. Whether the effect of increased bone turnover is identical in cortical and trabecular bone in unknown. Using a cross sectional design we aimed to investigate which bone compartment is affected.Methods: Nineteen newly diagnosed patients with Graves’ disease (GD) and nineteen euthyroid controls matched on age, gender and menopausal statu...

Objectives: Patients with anorexia nervosa (AN) are at high risk of reduced bone mass. The aim of this intervention study was to investigate the long-term effects on bone and body composition three years after intense weight gain therapy.Methods: Twenty-five female AN patients, mean age 20.1 years, mean BMI of 15.5 kg/m2, were included. Twenty-two patients fulfilled the treatment for 12 weeks with a high-energy diet. Body composition and bone ...