Bone Abstracts

Background: The mineral content of the skeleton in children may be estimated by a number of methods including DXA-scanning, ultrasound, pQCT-scanning and from plain radiographs. Recently, a new method offering an estimating of the bone mineral content in children based on computerised assessment from hand radiographs has been introduced. The new measure is named bone health index (BHI) and expresses the mineral content in the metacarpal bones divided by the volume of the same ...

Despite the improvement in bone’s molecular, metabolic and live-cell imaging, histological investigation remains most crucial in bone biology for diagnostic and research purposes. Therefore, fixation of bone samples – especially for electron microscopy investigation – is critical to the ultrastructural analysis. Up to date, chemical fixation of bone tissue is performed at room temperature resulting in a compromised ultrastructure of bone sample. In this study, w...

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Introduction: Micro-RNAs (miRNAs) are important post-transcriptional regulators. By binding to complementary RNA strands, they affect mRNA levels and/or mRNA translation. We have previously identified ~90 miRNAs with significant expression levels, with a subset of miRNAs exhibiting interindividual and/or gender differences in expression. In the present project, we have investigated the impact of treatment of parathyroid hormone (PTH) and dexamethasone (DEXA) on global miRNA ex...

Bone resorption and deposition occur in a tightly regulated fashion reflecting the coupled activities of osteoclasts and osteoblasts. Several pathological conditions perturb this balance between bone synthesis and resorption, including osteoporosis and skeletal metastases. The uncoupling of remodeling activities contributes to disseminated tumor cells homing to the bone and to tumor growth in bone. Therefore, a reliable marker of bone remodeling would be useful to provide a st...

Background: Bone marrow edema (BME) is a localised bone lesion. We hypothesize that structural bone alterations increase the susceptibility to BME. Aim of this study was to analyse bone micro structure, bone mineral density (BMD) and serum fasting bone turnover marker (BTM) values in patients with BME.Methods: We compared 14 nonosteoporotic patients (43.7±19.2 years) with atraumatic BME of lower limb to 35 age-matched healthy controls (HC). HR-pQCT ...

Background: Osteogenesis imperfecta (OI) as a rare disease is characterized by reduced bone mass, increased fracture rate, bone deformities and skeletal pain.Currently patients are treated with i.v. bisphosphonates regardless of the underlying mutation.Recently the gene causing OI type VI was described (SERPINF-1, altered RANKL-pathway). This leads to a new understanding of the underlying pathophysiology and offered a new therapeut...

Background: Osteogenesis imperfecta (OI) is a rare disease characterized by increased fracture rate and bone deformities. Patients are classified by phenotype and most are affected by mutations in COL1A1/2.Patients with OI type V present with specific clinical symptoms including hyperplastic callus formation, only mildly decreased height, metaphyseal lines and a calcification of the membrane interossea of the forearm. The disease causing mutation for OI ...

Adiposity, physical inactivity and sedentary behavior have become an increasing problem during the past decade and raise concerns about future health. Increased sedentary behavior may change the body composition by increasing the fat mass (FM) relative to the lean mass (LM). These changes may influence bone health. This study aimed at evaluating the influence of BMI and body fat percent (BF%) and LM on children’s bone health represented by bone mineral content (BMC), bone...

Background: Osteogenesis imperfecta (OI) is a genetic disorder with low bone mass and bone fragility. Type VII OI is one of the autosomal recessive subtypes and clinically moderate to lethal. It is caused by mutations in the cartilage associated protein (CRTAP) gene. Currently <20 mutations are known.Case description: An 11-year-old Iraqi female was referred to our hospital after immigration to Finland. She had suffered numerous peripheral a...