Bone Abstracts

IκB Kinase β (IKKβ), a key component of NFκB signaling, plays an important role in bone disease and cancer. Genetic and pharmacological inhibition of IKKβ/NFκB signaling increase bone mass and protect against ovariectomy- and inflammation-induced bone loss. Here, we describe a previously unknown role of the IKKβ/FoxO3a axis in bone metastasis associated with breast cancer. We observed that IKKβ expression is prevalent in invasive breast ...

Recent studies have demonstrated the role of osteocalcin in energy metabolism regulation having a connection between this and bone metabolism. According to this, anti-osteoporotic drugs may exert different effects on energy metabolism. Thereby, our aim is to evaluate the effects of antiresorptive (Denosumab) and osteoanabolic (Teriparatide) drugs that reduce or increase respectively osteocalcin levels, on energy and bone metabolism by assessing of undercarboxilated osteocalcin...

Objectives: To investigate the possible relationship between neonatal anthropometric characteristics and bone turnover and growth markers in a sample of neonates and their mothers, taking into account the size for the gestational age.Methods: A sample which consisted of 20 small for the gestational age (SGA), appropriate for the gestational age (AGA), and large for the gestational age (LGA) randomly selected term neonates and their 20 mothers were analyz...

Objective: To determine if milk is always good for preventing osteoporosis in children anyway.Materials and methods: Worldwide bibliography review on the problem and our experience.Results: Studies performed in children and adolescents relate to the subject of the long-term relative effects on bone health of the protein content of the diet compared with that of the diet’s net load of acid in the body. Long-term acid loading in...

Aim: Determining level of vitamin D and other conditions in children with osteoporosis.Methodology: Bibliography review in a worldwide basis about the issue and what we have observed.Outcome: We studied the level of 25OHD3 in all patients with osteoporosis and osteopenia. 25OHD3 95% deficit was found in these patients when reduced bone mass occurs. There are several disorders for hypocalcemia. Intestinal malabsorption syndromes, re...

Glucocorticoids are the most commonly used drugs in medical therapy, released in stress and necessary for normal development in both humans and animals.The aim of this study was to investigate the effect of prenatally administered dexamethasone (Dex), a synthetic glucocorticoid, on the histomorphometry of the femur in the offsprings of spiny mice, as a precocial species, characterized by high fertility, and the rapid development of the fetal, allowing th...

Alterations in fetal nutrition result in developmental adaptations that permanently alter the structure, physiology and metabolism of the offspring. β-hydroxy-β-methylbutyrate (HMB) is the bioactive metabolite of leucine responsible for inhibiting proteolysis and for modulating protein turnover in vitro and in vivo.The aim of the study was to determine the effect of maternal administration with HMB on mineralization, geometry ...

Objectives: Nutrition in childhood is a major factor for healthy living during adulthood. Bone mass is influenced immensely by nutritional intake, especially protein intake which is very important for bone matrix and the integrity of skeletal structure. This study aimed to identify the effects of dietary protein intake on bone mineral density (BMD), bone mineral content (BMC) and performance of children aged 6–12 years old.Methods: A repeated measur...

Objectives: Bone mass development through childhood is very important for osteoporosis prevention during adulthood. Physical activity (PA) and/or exercise can influence positively bone matrix and its contents in pre-adolescents Sclerostin, a glycoprotein produced by osteocytes, promotes osteoclastic activity and it is associated with reduced bone formation. The purpose of this study was to describe the relationship between PA and sclerostin levels in pre-adolescent boys and gi...

Polyphosphates (polyPs) are inorganic phosphate chains found in many cell types with higher concentrations in bone cells. As a source of inorganic phosphate (Pi) and an effective calcium reservoir due to chelation, PolyPs enable total Ca2+ and PO42− concentrations above those required for apatite saturation. Alkaline phosphatase (ALP) cleaves Pi from polyP, thus polyPs may be involved in apatite mineralization.Aim: ...