Bone Abstracts

OPTN encodes a cytoplasmic protein optineurin which has been shown to play a role in autophagy. Recent GWAS studies have shown that variants within OPTN are associated with the risk of Paget’s disease of bone, a disease characterized by focal areas of increased bone turnover due to increased osteoclast activity, suggesting a possible role of OPTN in the regulation of bone metabolism.The aim of this study was to investigate the role of optineurin in ...

Vascular calcification is a ubiquitous pathology in the aged and diseased vasculature. Recently we have focused on the earliest events in the calcification process and have shown that calcification is initiated in small membrane-bound bodies, or matrix vesicles, derived from both apoptotic and stressed VSMCs. Under normal conditions, these vesicles are loaded with potent inhibitors of mineralization, including matrix Gla protein (MGP) and fetuin-A, which act to block or contro...

Background: Elevated plasma homocysteine levels are a risk factor for osteoporotic fractures. Supplementation with vitamin B12/folic acid lowers homocysteine levels. This study aimed to determine whether vitamin B12/folic acid supplementation reduces osteoporotic fracture incidence in hyperhomocysteinemic elderly.Methods: B-PROOF is a double-blind, randomized, placebo-controlled trial including 2 919 participants aged ≧65 years with elevated homocyste...

Delta-like 1/fetal antigen-1 (DLK1/FA1) is a negative regulator of bone mass in vivo as it inhibits osteoblast (OB) and stimulates osteoclast differentiation. However, the molecular mechanisms underlying these effects are not known. Thus, we studied the effect of DLK1/FA1 on different signaling pathways known to regulate OB differentiation. We identified DLK1/FA1 as an inhibitor of BMP2-induced OB differentiation. Stable overexpression of DLK1/FA1 in C2C12 cells or th...

The main cause of the bone destruction in rheumatoid arthritis (RA) is a destructive act of aggressively growing pannus, growth and angiogenesis of which are caused by the proliferation of fibroblasts in the synovium (S) due to the activation of fibroblast growth factor (FGF).Objectives: To reveal relationships of FGF with ultrasonic and arthroscopic and proliferative-destructive histological figures in RA.Methods: Complete compreh...

Introduction: Aggressive periodontitis (AgP) is an inflammatory disease causing rapid loss of teeth in young patients.Aim: Determine degree of impact of COL1A1 gene on likelihood of AgP development.Materials and methods: Study included 47 patients with AgP, 40 patients with osteoporosis (OP), and 64 healthy patients (HP). Polymorphic variant c.104-441G>T (COL1A1) was studied. Statistics: Fisher’s...

Introduction: Objective of the study is to assess the frequency of osteoporosis and osteoporotic fractures in rheumatoid arthritis (RA) patients with the onset in the age of 55 and elder.Methods: Seventy women with RA (mean age of 62.6 years, mean RA duration of 4.6 years) were examined with dual X-ray absorptiometry (DXA) in three locations (vertebral body L1–L4, femoral neck, and distal radius) and X-ray of vertebral with assessment by Felsenberg....

Perinatal infections appreciably defines the level’s of the neonatal deseases and death rates. The systemic inflammatory response syndrome at the infections can promote the softening of the bone’s tissue in pregnant women and their fetuses.Objectives: Definition of the connection of the level’s calcium-regulated hormones and bone tissue remodeling marker’s in blood at 32 (II) healthy and 48 (I) pregnant women with perinatal infections...

Chronic kidney disease (CKD) is defined according to the presence of kidney damage and level of kidney function – irrespective of the type of kidney disease (diagnosis). Among individuals with chronic kidney disease, the stages are defined based on the level of glomerular filtration rate. From infancy through young adulthood, the major causes of CKD arise from congenital abnormalities of the kidneys and urinary tract (CAKUT), acquired or congenital forms of nephrotic synd...

In advanced ER+ve breast cancer, the propensity of bone involvement is 85%. Similarly in advanced lung cancer, 30–40% of patients develop bone metastases, and as recent advances in lung cancer therapies improve survival, the number of patients living with bone metastases is expected to increase. At the same time there is a paucity of especially ER+ and osteoblastic animal models available. We present herein the development of four mouse models of breast and lung cancer su...