Bone Abstracts

Introduction and aims: Deficiency of vitamin D has been reported in subjects with many types of musculoskeletal pain. The aim of the present study was to determine the association between serum 25-hydroxyvitamin D (25(OH)D) and nonspecific skeletal pain in healthy Saudi women.Methods: Serum 25(OH)D were measured for 223 healthy women with nonspecific skeletal pain at different regions of the skeletal system including back pain. Serum 25(OH)D was measured...

Objective: Zoledronic acid (Zol) has been demonstrated to be an effective therapy to treat postmenopausal osteoporosis (PMO) in Chinese women in a 12-month post-marketing observational study (ZOOM study). As an I.V. bisphosphonates, Zol are exclusively excreted via the kidneys. We present a report of the renal function and safety data of once-yearly Zol 5 mg treatment.Subjects and methods: A total of 373 PMO patients from 30 different centers in China wi...

Bone metabolism disorders and hypercalcemia occur often in kidney transplant recipients.In 59 kidney recipients (aged 22–74 years, creatinine clearance > 50 ml/min) who were hypercalcemic on more than three consecutive previous visits, the following serum parameters were estimated 1–147 months posttransplant: iPTH, Ca total and ionized, Pi, total and bone alkaline phosphatase, crosslaps, 25(OH)D3, cyclosporine/tacrolimus trough levels. Urin...

Objectives: Bone disease is now well described in cystic fibrosis adult patients. CF bone disease is multifactorial but many studies suggested the crucial role of inflammation and chronic pulmonary infection. The objectives of this study were to assess the prevalence of osteoporosis in a current adult CF population and to examine its relationship with infections and inflammation.Methods: Patients were recruited in the adult CF Lyon Centre and assessed in...

Introduction: The aim was to examine serum levels of RANKL, OPG and TNF-α before and after curative surgery (PTX) in patients with primary hyperparathyroidism, and their relationship to bone turnover and bone loss.Patients and methods: A 46 patients with rather severe primary hyperparathyroidism (mean PTH=196 pg/ml, mean total Ca=11.4 mg/dl, spine osteoporosis in 50%, hip osteoporosis in a third) mean age of 63.3±12.3 years, 41 women/five males...

Background: Bone accrual during adolescence is the main contributor to peak bone mass. Bone remodeling is a balance between bone formation and resorption as directed by osteoblast and osteoclast activity, respectively. nitric oxide (NO) is a potent regulator of bone remodeling via mediating effects of cytokines, estrogen and mechanical strain. NO is synthesized from the conversion of L-arginine to L-citrulline by the enzyme nitric oxide synthase (...

In type 2 diabetes mellitus (T2DM) patients, an increased fracture risk is observed, although the bone mineral density is even higher than in non-diabetic patients, which raises the question of the quality of the organic and inorganic matrix in bone1,2. T2DM is also known to favor inflammation of the gingiva and paradontosis in general. However, little is known about the mineral nano-architecture in the mandible and about the possible influence of diabetes. Using sy...

RANKL, the receptor activator of nuclear factor kappa B ligand, is an essential factor for the formation of mature osteoclasts. Together with its receptor RANK and its antagonist Osteoprotegerin (OPG) RANKL is a key regulator in bone metabolism1. RANKL is a membrane-bound protein that can be segregated to a soluble form (sRANKL), whereas only the latter has been reported to be bioactive2. Due to its low circulating levels and the nature of the analyte bin...

Objectives: To confirm effect of intravenous treatment with ibandronate every three months in common population of postmenopausal women.Methods: Patients with postmenopausal osteoporosis, who fulfil ACR criteria for postmenopausal osteoporosis and were treated with intravenous ibandronate for two years, underwent DEXA examination.Results: A 50 women suffering from postmenopausal osteoporosis were treated with ibandronate i.v. every...

Background and objectives: The association between excess calcium intake and cardiovascular mortality has been reported, but the association has not yet been explored according to serum vitamin D status. Thus, we investigated the relation of dietary calcium intake and Framingham risk score (FRS) according to serum 25-hydroxyvitamin D (25(OH)D) status.Methods: A total of 7809 subjects (3452 males and 4357 female) aged over 40 years from the data of the Ko...