Bone Abstracts

It has been established that disturbances of intracellular signaling pathways strongly contribute to the oncologic process. Indeed, phosphatidylinositol-3-kinase (PI3K) became a key target in cancer therapy, due to its high frequency of mutation and/or gain of function of its catalytic subunits in cancer cells. In this context, we investigated the in vitro and in vivo effects of a new PI3Kα inhibitor, BYL719 (Novartis Pharma), on bone cells and its thera...

Osteosarcoma is the most common primary malignant bone tumor, characterized by osteoid production and/or osteolytic lesions of bone. Despite recent improvements in chemotherapy and surgery, the problem of non-response to chemotherapy remains and constitutes a poor prognosis parameter. Consequently new therapeutic strategies aim to improve the overall rate of survival. The present work investigated the therapeutic interest of a dual phosphatidylinositol-3-kinase (PI3K)/mammalia...

Introduction: Bisphosphonates are drugs of first choice in the treatment of postmenopausal osteoporosis; they inhibit bone resorbtion.Aim: This study evaluates the efficiency of bisphosphonates (alendronic acid+cholecalciferol 70 mg/5600 IU per weekly vs risedronic acid 35 mg/weekly vs ibandronic acid 150 mg/monthly) after 1 year of therapy.Methods: We present the results of a retrospective study which included 40 women with postme...

Background: Association between high serum homocysteine (S-Hcy) levels and low bone mineral density (BMD) and increased fracture risk in postmenopausal women has been repeatedly documented. There are scarce data concerning S-Hcy and bone health in children and adolescents.Patients and methods: We assessed S-Hcy levels in 37 children and adolescents (22 boys and 15 girls; mean age 13.9±3.5 years) with prevalent low-energy trauma fractures (mean 3.3&#...

Background and objective: High-resolution magnetic resonance imaging (hrMRI) can assess trabecular bone microarchitecture but the number of image slices required for reliable assessment is unclear.Methods: MRI was performed just below the growth plate of the proximal tibia from 20 healthy controls (all female; median age 21 years (range 18–35) and 10 cases (three mals: seven females; median age 19.5 years (range 16–48) with known bone abnormali...

The aim of this study was to estimate the structure of pain syndrome and reveal the presence of neuropathic pain component in patients suffering from the osteoporosis and low back pain.Material and methods: We have examined 107 patients aged 45–89 years (average age 68.1±1.2 years). Patients were divided into 2 groups: A – patients with osteoporosis (n=49), B – patients with low back pain (n=58). And according to age...

Objective: Children in rural areas have inadequate nutritional intake, hence their muscle function may be compromised. The objective of this study was to study the determinants of muscle function in rural Indian school going children.Methods: We cross sectionally studied 232 prepubertal school going children (106 girls) aged 6–11 years, from 2 different villages in rural area around Pune city in July 2018. Height, weight, body composition (bioelectr...

There is increasing evidence for the key role of osteocytes in the regulation of bone remodeling. One of the main products of these cells, sclerostin, inhibits bone formation and may also stimulate bone resorption. To our knowledge, there are few data in prostate cancer (PC) patients especially in patients with hypogonadism related to androgen deprivation therapy (ADT). The aim of this study was to compare serum levels of sclerostin in ADT-treated and untreated PC patients wit...

Introduction: The FRAX model is a new method to assess fracture risk and this aspect is important in menopause. The DXA is still the golden standard but the relationship between these two instruments is complex.Aim: We correlate the 10-year absolute fracture risk of hip (10-yH) and major fractures (10-yM) based on FRAX with or without bone mineral density (BMD) with lumbar DXA in menopause women, and we use a statistical model to find out whether the vit...

Background: Previous TBS studies in type 2 diabetes have suggested a deterioration of bone microarquitecture that could be related to a higher risk of fractures. However, there are no information in liver transplantation (LT) patients with new-onset diabetes after transplantation (NODAT).Our aim was to investigate TBS in LT patients and the influence of NODAT in these patients. Also, we investigated the relationship between TBS and body composition param...