Bone Abstracts

Introduction: The patients with rheumatoid arthritis (RA) are less physically active than the general population. The aim of the study is to assess the effect of two exercise programs on the functional status of patients with early RA.Methods: Fifteen patients with early RA underwent ten high-intensity dynamic exercises using Enraf-Nonius gym for 45–60 min, including aerobic part (En-Cardio) and 18–20 muscle-strengthening exercises (En-Dynamic ...

Objectives: We aimed to analyze bone mineralization in postmenopausal women of Southern Apulia and to evaluate the effect of obesity-related phenotypes as BMI ≥30 kg/m2, diabetes, hypertension and cardiovascular diseases.Methods: The PROF project is a population-based study on 3.356 subjects (40–99 years) analyzed by phalangeal quantitative ultrasound (QUS) to evaluate bone mineral status. A total of 2.756 postmenopausal women were ...

Crohn’s disease often results in abnormalities in bone strength, and ultimately increases the risk of fragility fracture. Up to 55% of patients with Crohn’s disease have bone mineral density in the osteopenia range up to 50% of osteoporosis. Glucocorticoid is frequently used in the treatment of Crohn’s disease and is associated with osteoporosis and increased fracture risk. It has been reported that osteoporotic fractures in patients with Crohn’s disease ar...

Introduction: Minodronate, a highly potent, new-generation bisphosphonate (BP), is the first BP available as a once-monthly oral regimen in Japan. The aim of the present study was to investigate the effects of once-monthly oral minodronate on bone turnover markers (BTM) and bone mineral density (BMD) in osteoporotic patients previously using daily or weekly BPs in real clinical practice.Methods: We conducted a prospective multicenter study involving 11 i...

Numerous studies in adult patients with type 1 diabetes (T1D) described an association with reduced bone mineral density, altered bone geometry and osteoporosis. Epidemiologic data on hip fractures demonstrate an increased risk in a large adult population with T1D. Diabetes is therefore categorized as adversely affecting the skeleton.In children and adolescence observations have been more controversial regarding bone mineral content, bone mineral density...

Background and methods: A specific skeletal complication in children with CKD is growth impairment. The effects of recombinant human growth hormone (rhGH) therapy on bone turnover and bone material quality are not well understood. Bone matrix mineralization density distribution (BMDD) as assessed by quantitative backscattered electron microscopy (qBEI) is an important determinant of bone material quality and reflects bone turnover (average tissue age) and mineralization kineti...

Introduction: Osteopenia is a well-known complication of anorexia nervosa (AN) in older adolescents and adults, especially in those with a long duration of the disease and a severe underweight.Aim: We investigated whether young premenarchal girls with AN have similar risk factors for a disturbed bone growth and mineralization.Methods: Twenty-four female premenarchal AN patients as well as 24 age and height matched female controls u...

Young transsexuals at a minimum age of 12 years are treated with GnRH-analogues (GnRHa) to suspend pubertal development until the addition of hormones of the desired sex is started at a minimum age of 16 years. The effect of this treatment on adult bone mineral density (BMD) is still unknown. We aimed to assess BMD at the age of 22, as this is near its peak in healthy individuals.In this prospective observational study 19 female to male (FtM) and 16 male...

Background: We present an interesting case of a young child under bisphosphonates, for the treatment of juvenile osteoporosis (IJO), that developed a ‘bone in bone sign’, in several vertebral bodies, evident both on radiographs (CRX) and on magnetic resonance (MR) studies.Presenting problem: A 13-year-old girl was admitted in our hospital complaining with thoracolumbar pain. The patient had been diagnosed with IJO 2 years ago because of.a histo...

The purpose of this presentation is to present the guidelines for recommending surgery for asymptomatic primary hyperparathyroidism, based on a workshop held in 2013. The indications for surgery were: i) a serum calcium more than 1 mg/dl (or 0.25 mmol/l) above the reference interval; ii) a low bone density (T-score −2.5 or less at the lumbar spine, total hip, femoral neck, or distal radius 1/3) or presence of vertebral fracture; iii) chronic kidney disease stage...