Bone Abstracts

Osteogenesis imperfecta is a clinically heterogeneous heritable connective tissue disorder. Most OI cases are due to mutations in type I collagen genes, COL1A1 and COL1A2 encoding the pro-alpha1(I) and pro-alpha2(I) chains respectively. However, genotype-phenotype correlation has not been completely elucidated yet. In this study we evaluated a familial case including a mother and a daughter, classified as OI type I. The daughter had more severe clinical featu...

It is well known that sex hormone deficiency leads to increased bone turnover and subsequent bone loss. The metabolism of estrogens involves, among others, oxidation (mainly hydroxylation) by CYPs. The aim of this study was to determine whether Leu432Val polymorphism in the CYP1B1 gene is present also in Slovak population and subsequently, if it is associated with femoral and spinal bone mineral density (FBMD and SBMD), bone remodeling markers and fracture incidence in this po...

Introduction: The loss of muscle mass (MM) is a serious problem which has been demonstrated in patients with rheumatoid arthritis. There are few studies about the loss of MM in patients with spondyloarthritis (Spa). In a recent case–control study in our department, the risk of sarcopenia in Spa patients was twice than in a healthy control group.Objective: To assess muscle mass index (MMI) in patients with axial Spa and to search a relation between s...

Introduction: Advancing age is associated with decline in bone and muscle mass and quality. Sarcopenia, one of Geriatric syndromes, is defined as the age-associated loss of skeletal muscle mass and function resulting in disability, poor QOL and death.Objective: To evaluate the prevalence of sarcopenia and its association with osteopenia/osteoporosis in Korean PMW.Materials and methods: Subjects: total 225 Korean PMW over 50 years w...

Introduction: The purpose of this study was to determine osteoporosis (OP) and osteopenia in patients with various rheumatic diseases depending on the duration of use glucocorticosteroids (GCS) and daily dose of GCS.Methods: The study included 125 patients (90 women and 25 men) with various rheumatic diseases receiving GCS therapy. BMD was measured by DXA (Hologic). Patients were divided into two groups. Group I included postmenopausal women and men over...

Introduction: Currently, osteoporosis is mainly diagnosed through dual-enargy X-ray absorptiometry (DXA). However, DXA cannot be used for early diagnoses through population mass screenings because of issues related to ionizing radiation employment. Aim of this study is to perform a preliminary clinical validation of a new ultrasound (US)-based method for vertebral densitometry.Methods: A total of 270 women were included in this study according to the fol...

Introduction: The FRAX algorithm, by evaluating the 10-year risk of hip and major osteoporotic fractures, weights greatly on the clinicians’ decision to treat a patient with an antiosteoporotic drug. The FRAX tool has recently been validated for the Portuguese population.With this work, the authors intended to assess FRAX accuracy when retrospectively performed in patients with hip fracture.Methods: A retrospective cohort stud...

Discordance of T-score is frequently observed and affects to therapeutic strategy in osteoporosis. Z-score discordance in premenopausal women has not been reported yet. In addition, despite of important role of low bone mineral density (BMD) in premenopausal women to predict osteoporotic fracture in postmenopausal age, there are very few reports on the status of low BMD in healthy premenopausal women. To investigate the current status of idiopathic osteoporos...

Objectives: To find the predicting factors for bone density in premenopausal women.Methods: Two hundred and forty-five premenopausal women without factors that can cause secondary osteoporosis were analyzed. Age, height, weight, change of height from peak height, history (Hx) of fracture, family Hx of hip or other fracture, Hx of estrogen use, calcium or vitamin D supplementation, smoking and previous Hx of amenorrhea more than 3 months were questioned. ...

Hepatic osteodystrophy is an important complication of chronic liver disease associated with fractures resulting in pain, deformity and immobility. The aim of the study was to examine association of severity of alcoholic liver cirrhosis with areal bone mineral density (BMD) and to estimate bone geometric strength of the proximal femur in those patinets. The study included 27 male patients with alcoholic liver cirrhosis and control group of 36 healthy patients. Laboratory testi...