Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp500 | Other diseases of bone and mineral metabolism | ECTS2013

IFITM5 c.−14C>T mutation causes variable type V osteogenesis imperfecta phenotype and decreased COL1A1 expression but increased mineralization by cultured proband osteoblasts

Reich Adi , Bae Alison S , Barnes Aileen M , Cabral Wayne A , Chitayat David , Marini Joan C

Introduction: Osteogenesis imperfecta (OI) is a genetically heterogeneous disorder characterized by bone fragility. OI type V, with autosomal dominant inheritance, is characterized by ossification of the forearm interosseus membrane, radiodense metaphyseal bands, propensity for hyperplastic callus formation, and mesh-like lamellation on bone histology. Type V OI probands are reported to have white sclerae and normal teeth. Recent reports identified the cause of type V OI as a ...

ba0002p50 | (1) | ICCBH2013

Bioelectrical impedance as a screening tool for low bone mass in Indian children and adolescents

Ekbote Veena , Khadilkar Anuradha , Chiplonkar Shashi , Mughal M Zulf , Khadilkar Vaman

Objectives: i) To assess bone (BMC) by BIA in apparently healthy Indian children. ii) To generate percentile curves for BIA measured BMC by age/gender. iii) To investigate relationship between BMC measured by BIA and DXA in separate subset.Methods: In a multicentre study, 4154 children (2298 boys), 5–18 years underwent BMC assessment by BIA. BMC for age percentiles were computed using LMS method. In 41 children (not from the multicentre study) total...

ba0002p52 | (1) | ICCBH2013

Incidence of fractures in 2–18 years old affluent Indian children: a multicentre study

Ekbote Veena , Khadilkar Anuradha , Pillay Deepa , Chiplonkar Shashi , Mughal M Zulf , Khadilkar Vaman

Objective: Fractures represent a common injury during childhood and adolescence. Knowledge of epidemiology of fractures is crucially important for implementation of prevention strategies for target population. Our objective was to evaluate incidence of fractures in Indian children and adolescents and to investigate association of fractures with physical activity.Methods: Data on history of fracture, age, site of fracture and physical activity were collec...

ba0002p54 | (1) | ICCBH2013

Association of calcium and dairy intake with growth in Indian children

Ekbote Veena , Khadilkar Anuradha , Chiplonkar Shashi , Mughal M Zulf , Khadilkar Vaman

Objective: Optimal intakes of calcium and milk are necessary in children and adolescents to facilitate not only mineralization but also growth in stature. Low intakes of calcium and also, of milk and milk products in Indian children have been reported. Hence, the objective was to study Indian children’s growth with respect to their calcium and dairy intakes.Methods: We studied 220 children (boys 104, age range 2–16 years). Data on their height,...

ba0002p56 | (1) | ICCBH2013

Effect of puberty on the muscle–bone relationships in Indian children and adolescents

Khadilkar Anuradha , Sanwalka Neha , Mughal M Zulf , Chiplonkar Shashi , Ekbote Veena , Khadilkar Vaman

Objective: To describe changes in the muscle–bone unit, assessed as the ratio of bone mineral content (BMC) to lean body mass (LBM) at skeletal sites during puberty in Indian males and females, after adjusting for age and fat.Methods: Data on arm, leg and total body (less head) BMC, LBM and fat mass (FM) assessed by DXA for 888 apparently healthy children and adolescents (426 females), 5–17 years of age from a cross-sectional study used to gene...

ba0002p78 | (1) | ICCBH2013

Variable relationship of fat mass and bone with pubertal staging in obese and normal weight Indian children and adolescents

Khadilkar Anuradha , Ekbote Veena , Pandit Deepa , Chiplonkar Shashi , Mughal M Zulf , Khadilkar Vaman

Objective: In children, factors such as age and puberty are confounders when investigating associations of fat or lean with bone mineral content (BMC). Our aim was to assess influence of fat on BMC in overweight/obese (ow/ob) and normal weight (nw) children at different stages of puberty.Methods: Cross-sectionally, 244 children+adolescents (6–16 years) (73nw, 177ow/ob) were assessed (tanner staging (TS), body composition (DXA) (total body BMC, lean ...

ba0003oc1.1 | Phosphate metabolism, fracture repair and osteoarthritis | ECTS2014

Type 2 cannabinoid receptor protects against osteoarthritis in mice

Sophocleous Antonia , Borjesson Anna E , Salter Donald M , Ralston Stuart H

Background: Cannabinoid receptors are expressed in synovial joints but their role in joint disease is unknown. Here we examined the role of the type 2 cannabinoid receptor (CB2) in the pathogenesis of age-related osteoarthritis and osteoarthritis caused by destabilisation of the medial meniscus (DMM) in WT and CB2-deficient mice (Cnr2−/− mice).Methods: The severity of arthritis was graded histologically according to standard techni...

ba0003pp258 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Socio-economic status and hip fracture risk: a region-wide ecological study

Reyes Carlen , Javaid M Kassim , Cooper Cyrus , Diez-Perez Adolfo , Prieto-Alhambra Daniel

Purpose: To determine the association between socio-economic status (SES) and risk of hip fracture.Methods: Retrospective cohort study. We used a population database which contains primary care and hospital inpatient records of over >5 million people. Anyone registered in this database in 2009–2012 and resident in an urban area was eligible. Main measures: a validated SES composite index (accounting for proportion of unemployed, insufficiently e...

ba0004p33 | (1) | ICCBH2015

In utero effects of iron status on infant fibroblast growth factor-23 and mineral metabolism

Braithwaite Vickie S , Prentice Ann , Darboe Momodou K , Prentice Andrew M , Moore Sophie E

Fibroblast growth factor-23 (FGF23) is a bone derived phosphate-regulating hormone which is elevated in hypophosphataemic rickets. Recent findings demonstrate iron deficiency as a potential mediator of FGF23 expression and murine studies have shown in utero effects of maternal iron deficiency leading to increased FGF23 concentration and disordered bone development (Clinkenbeard. JBMR 2013). Children with rickets in rural Gambia, West Africa, have high prevalences of i...

ba0005p472 | Paediatric bone disease | ECTS2016

Osteogenesis imperfecta: clinical and laboratory aspects, about five cases

Nassar Kawtar , Janani Saadia , Rachidi Wafae , Mkinsi Ouafa , Cherqaoui Abdelmounim , Aboumaarouf M

Introduction: Osteogenesis imperfecta is a rare constitutional bone disease. The bone matrix is poor because of the often mutation on the gene coding for collagen I, leading to many fractures. Classification Sillence completed by Glorieux, describes the clinical variability. The management should be done case by case.Study objective: Evaluate the clinical profile, biological and radiological of 5 newly diagnosed cases.Material and ...