Bone Abstracts

Objective: The forearm is a common fracture site during childhood, but DXA pediatric reference data for areal bone mineral density (aBMD) at the ultradistal (UD) radius are lacking. The objective of this study was to first, develop age-, sex-, and ancestry-specific reference data for UD radius aBMD; second, assess the relationship between UD radius aBMD and a) other DXA aBMD measures and b) radius bone volumetric density and geometry by pQCT; and third, examine the tracking of...

Introduction: Conventional treatment of X-linked hypophosphataemic rickets (XLH) involves administration of oral phosphate and vitamin D analogues. An important treatment goal is to heal rickets which is assessed by normalisation of serum alkaline phosphatase (ALP) levels and resolution of radiological signs of rickets.Objectives: To determine the usefulness of serum ALP in assessing disease severity on wrist and knee radiographs as determined by rickets...

The aim of this study was to evaluate the trabecular bone score (TBS), bone mineral density (BMD) and body composition in women of various ages.Materials and methods: 494 women aged 41–89 years (mean age, 63.6±0.4 years; mean height, 1.61±0.003 m; and mean weight, 74.0±0.6 kg) were examined. The patients were divided into the following age-dependent groups: 40–49 years (n=35), 50–59 years (n=130), 60–6...

Background: Cardiovascular disease is the leading cause of death in pediatric (ped) and adult ESRD patients. Left ventricular hypertrophy (LVH) is an independent predictor of mortality in ESRD. Besides traditional risk factors, such as high BP & fluid overload, high plasma FGF23 is associated with LVH in adult ESRD patients. Little is known about Kl, the renally produced cofactor of FGF23 for phosphorus (P) homeostasis. We studied ped HD patients for risk factors for LVH, ...

Background: Vitamin D status is associated with bone health. Vitamin D deficiency leads to decreased bone formation and increased bone resorption. 25-hydroxyvitamin D (25(OH) D), parathyroid hormone (PTH) levels in children could affect bone turnover, and in turn, the bone markers should reflect vitamin D condition. In children the relationships among 25(OH) D, PTH and bone turnover markers are remain.Objective: To explore the associations among serum 25...

Introduction: The availability of bone turnover markers (BTMs) that are kidney independent has facilitated the monitoring of bone turnover in renal patients with hyperparathyroid bone disease. The effects of Cinacalcet on BTMs and on the relationship between parathyroid hormone (PTH) and BTMs were studied.Methods: The formation marker procollagen type 1 N propeptide (P1NP) and resorption marker tartrate resistant acid phosphatase 5b (TRACP5b) were measur...

Background: Osteoporosis is a leading cause of morbidity in patients affected by β-thalassaemia major (TM) and intermediate thalassaemia (TI). Appropriate supportive care and identification of long-term sequels of therapy are important in thalassaemic patients. As low bone mineral quality (BMQ) in patients can be considered a marker of possible degeneration to osteopenia and osteoporosis in adulthood, we evaluated bone features in a young population followed at ‘A. P...

Introduction: Serum 25(OH)D concentrations for optimal bone metabolism in children is unknown. Only few data exist describing the effects of increasing serum 25(OH)D on bone metabolism markers.Aim: The aim of the study was to explore the association between serum 25(OH)D and bone metabolism markers in children.Patients and methods: Serum levels of bone formation (OC, P1NP) and bone resorption (CTx) markers (Cobas e411, Roche Diagno...

The literature has suggested that bone mineral content is modulated by muscle mass and activity. We investigated the relationship between DXA assessed total body bone mineral content, total body lean mass, appendicular lean mass and obesity (a possible marker of inactivity) in a population of 73 boys between the age of 7 and 19 using a Norland XR-46 system.Regression analysis shows that in these growing boys there is a strong positive relationship betwee...

Introduction: The purpose of this study was to determine osteoporosis (OP) and osteopenia in patients with various rheumatic diseases depending on the duration of use glucocorticosteroids (GCS) and daily dose of GCS.Methods: The study included 125 patients (90 women and 25 men) with various rheumatic diseases receiving GCS therapy. BMD was measured by DXA (Hologic). Patients were divided into two groups. Group I included postmenopausal women and men over...