Bone Abstracts

Pathophysiological calcification in the vasculature favours cardio- and cerebrovascular diseases. In patients with chronic kidney disease vitamin K metabolites are associated with decreased vascular calcification.We investigated the expression of vitamin K dependent proteins (VKDPs) in vessels and bone to identify differences in expression pattern during atherosclerosis (AS) stages and compare the two tissue profiles.Gene expressio...

Bone mineral density (BMD) changes were estimated in kidney recipients. In 63 patients aged 24–64 years, measured creatinine clearance at the end of the first posttransplant year was >50 ml/min and remained stable over the study period, bone mineral density (BMD) was estimated in the lumbar spine, femoral neck, Ward’s triangle and the distal third of the radius using dual energy absorptiometry (DEXA) 0.1–4, 12–18 and 23–36 months after transplantat...

Objective: To investigate the characteristics and related factors of bone mineral density (BMD) in men of different ages with type 2 diabetes.Methods: Four hundred and forty four male patients diagnosed with type 2 diabetes and 208 healthy men were involved from 2013 to 2014. The BMD of all men including lumbar spine (L1–L4), femoral neck, trochanter, and total hip were detected using dual-energy X-ray absorptiometry produced by the US company. We g...

Bone is a tissue that continually adapts to changing external loading conditions (so-called modeling) and has the capacity for self-repair and renewal (remodeling). These processes construct and reconstruct the skeleton by the removal and formation of bone packets that mediate the size, architecture, mass, and consequently the bone’s strength, allow bones to perform their mechanical functions successfully over long periods of time. Both adaptation and self-repair are beli...

Objectives: To evaluate the frequency of low serum alkaline phosphatase (ALP) activities in patients referred to a tertiary children’s hospital. Another item was to explore potentially missed diagnoses and to evaluate the role of laboratory screening for hypophosphatasia.Study design: A retrospective evaluation over an 6-year period (between December 2010 and December 2016) carried out to identify children and adolescents, referred to Anna Meyer Chi...

Introduction: The clinical diagnosis of mild forms of hypophosphatasia [HPP], a rare genetic bone disease, is often made in adulthood, on the basis of persistently low serum levels of alkaline phosphatase [ALP], often coupled with signs of poor bone/teeth mineralization.Case report: A 50-year-old male on treatment with vitamin D supplementation because of osteoporosis of lumbar spine (T-score –3.2) and femoral neck (T-score –2.4), was referred ...

Objective: Public Health England recommends that children in the United Kingdom (UK) aged over 1 year should take a vitamin D supplement containing 400 IU/day. Commercially available children’s multivitamin and vitamin D supplements were surveyed to determine the vitamin D content.Methods: Multivitamins and vitamin D supplements marketed at children <12 years and sold by nine UK supermarkets and health supplement retailers were surveyed. The vit...

Objectives: Bone, muscle and fat share common mesenchymal origins yet current methods separately examine lean, fat and/or bone content. We hypothesized specific musculoskeletal phenotypes derived from relative contributions of each tissue.Methods: Design: We obtained information from the 6-year follow-up of mother–offspring pairs within the Southampton Women’s Survey, a prospective population-based cohort study of 12 583 initially non-pregnant ...

Fractures are common in childhood, but multiple fractures during growth could indicate osteoporosis. Children with frequent fractures might benefit from further investigations for osteoporosis and as such, obtaining an accurate fracture history is important. The 2013 International Society for Clinical Densitometry Paediatric Osteoporosis Position Statement defined a clinically significant fracture history as two long bone fractures before age 10 years or three long bo...

Background: Duchenne muscular dystrophy (DMD) is characterised by progressive muscle weakness leading to loss of mobility, cardiomyopathy, and respiratory insufficiency. Typical initial manifestation in boys (X-linked disorder) comprises proximal muscle weakness and calf hypertrophy. Osteogenesis imperfecta (OI) is a clinically heterogenous heritable connective tissue disorder with increased bone fragility. Fractures rise from little or no apparent trauma.<p class="abstext...