Bone Abstracts

Bisphosphonates are used to treat bone disease characterised by increased bone resorption by inhibiting the activity of mature osteoclasts, resulting in decreased bone turnover. Bisphosphonates may reduce the population of osteoclast precursor cells (OPCs). Our aims were to investigate the effect of bisphosphonates on i) OPCs and ii) bone turnover in postmenopausal women with osteoporosis compared with healthy premenopausal women. Participants were 62 postmenopausal women (mea...

The purpose of this study was to analyze the influence of diet supplemented with hydrosoluble soy extract – HSE in bone mass of male and healthy Wistar rats. Sixteen (16) 30 days old animals were kept in controlled conditions with light/dark cicle and fed with commercial food and filtered water. Randomized into two groups: control group received 500 ml of water and 300 g of food, daily; supplemented group S, in addition of water and food, they also received 500 ml of soy ...

MicroRNAs are important regulators of gene expression with documented role in bone metabolism and osteoporosis. Moreover, the use of miRNAs constitutes potential therapeutic targets. Our aim was to identify miRNAs differentially expressed in fractured compared to healthy bone. Additionally, we performed a miRNA profiling of primary osteoblasts to assess the origin of the differentially expressed miRNAs. Total RNA was extracted from fresh femoral neck trabecular bone from women...

Introduction: The FRAX tool can be used to assess absolute fracture risk, but the majority of treatment decisions are still based on measurements by DEXA. In remote rural Greek areas, after the socioeconomy crisis, access to the nearest DEXA facility became more difficult.Purpose: Role of combined QUS and FRAX in the identification of low risk patients who do not require DEXA applying a FRAX threshold of 4% for the 10-year major osteoporotic fracture pro...

Phosphorus intake in western countries is high due to abundant consumption of animal protein and also because of the expanding use of highly absorbable food additive phosphate (FAP) salts in food processing. P is essential for hydroxyapatite in bone, but short-term studies have shown that high P, especially FAP, intake has acute negative effects on bone metabolism. In this study, we investigated the associations between dietary P intake and bone turnover markers by using a cro...

Treatment of postmenopausal osteoporosis with bisphosphonates reduces bone resorption and formation. Sclerostin, an osteocyte regulator of bone formation may be involved in these changes. Some studies have reported an increase in sclerostin associated with bisphosphonate treatment while others have reported a decrease. The aims were to determine the effect of bisphosphonates on i) circulating sclerostin and ii) PINP in postmenopausal women with osteoporosis. We studied 92 post...

Background: Denosumab is licensed for the treatment of osteoporosis in the UK. Guidance issued by NICE and SMC in indicated that Denosumab may be used in the treatment of patients with postmenopausal osteoporosis who are unsuitable for other treatments. Here we have reviewed the clinical characteristics of patients treated within a secondary care referral centre adverse events encountered during treatment.Methods: We reviewed data from 75 consecutive pat...

Bisphosphonates (BPs) including alendronate (ALN) are the most widely prescribed therapy for post-menopausal osteoporosis. Despite their overall excellent safety record and efficacy in reducing fractures, concerns have been expressed lately regarding potential detrimental effects due to prolonged bone turnover reduction, although no definite cause–effect relationship has been established to date. The purpose of the present study was to determine bone material quality by R...

Tea is the second most consumed beverage in the world, next to water. The popularity of tea is determined by healthy properties connected with the presence of antioxidants, hence tea can be classified as functional food. Cadmium (Cd) and lead (Pb) are toxic metals commonly occurring in the human environment with exposure ~5 and 35 mg/kg Bw per week respectively.Thirty growing male Wistar rats (12 weeks old, 326.4±31.0 g) were used. Rat were fed ...

Objective: Nutritional rickets in Nigerian children is primarily due to dietary calcium deficiency and heals with calcium supplementation. Our aim was to determine the optimal dose of calcium for treatment of children with rickets due to dietary calcium deficiency.Methods: At the Jos University Teaching Hospital, 65 Nigerian children with radiographically-confirmed rickets were randomized to daily supplemental calcium intake of 500 mg (n=21), 10...