Bone Abstracts

Rooibos (Aspalathus linearis) tea is a refreshing and caffeine-free tea indigenous to the Western Cape regions of South Africa. This tea, which is rich in polyphenols and antioxidants, has shown many beneficial effects in health, however, its anti-osteoclastogenic potential remains unexplored. In this study, the in vitro effects of an aqueous extract of fermented rooibos tea were examined on osteoclast formation and bone resorption in RAW264.7 murine macropha...

An increasing amount of scientific evidence suggests that western diet is a risk factor for osteopenia and osteoporosis. Indeed, metabolic acidosis, occurring after high levels of protein intake, may adversely impact on the skeleton by disrupting calcium metabolism, and leads to a decrease of bone mineral density (BMD). Currently, the prevention and treatment of osteopenia and osteoporosis are mainly based on lifestyle modifications (i.e. exercise, quitting smoking and ensurin...

We previously elucidated that β-adrenergic blockade attenuates high fat diet induced obesity development and such an effect is associated with suppressed pancreatic lipase (PNLIP) expressions. In the present study, we tested whether β-adrenergic blockade downregulates bioactive osteocalcin secretion in osteoblasts, thereby reduces PNLIP secretion in pancreatic acinar cells.Forty of male 6wk old C57BL/6 mice were assigned into control diet (CON)...

Hyperthyroidism in mice is associated with a low bone mass, an increased bone turnover and high serum levels of sclerostin, a potent Wnt inhibitor. Here, we explored the effects of either reducing bone turnover with bisphosphonates or increasing bone formation with neutralizing sclerostin antibodies (Scl-Ab) on bone mass and estimated strength in hyperthyroid mice.Twelve-week-old C57BL/6 male mice were rendered hyperthyroid by adding L-thy...

Background: Hypophosphatasia (HPP) is a heterogeneous disease; it can reveal itself at any age, through a wide range of symptoms. Findings of childhood (juvenile) HPP ranges from low bone mineral density for age with unexplained fractures to rickets, and premature loss of primary teeth with intact roots. We described a boy with the childhood form of hypophosphatasia presenting with short stature without rickets findings.Case report: An 11-year-old boy wa...

Background: Osteopetrosis (OP) is a bone disease which is characterized by increased bone density. Autosomal dominant osteopetrosis type II (ADO II, also called Albers-Schönberg disease) is the most common type and it is caused by heterozygous mutations in the chloride channel 7 (CLCN7) gene.Presenting problem: To present a patient with known medical and family history of osteopetrosis, who was diagnosed with Growth Hormone (GH) deficiency and was t...

Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by fragile bones susceptible to fractures. No definite cure for OI exists. Bisphosphonates, although not implicitly recommended in children due to deficient efficacy and safety data, have been administered off-label to OI patients for over 20 years. Short-term adverse effects of intravenously administered bisphosphonates are generally mild. Although anemia is a known side effect of bisphosphonates in adults,...

Metabolic bone disease (MBD) of prematurity is a well-recognized complication of preterm birth. Yet there is limited evidence for the optimal assessment, monitoring, and subsequent bone health management.Retrospective audit of 171 infants born <32 weeks’ gestation between November 2012 and January 2014 at three Monash Health neonatal units (Melbourne, Australia) was undertaken. Infants had mean gestational age (GA) 28.6±2.1 weeks and birth ...

Background: This study was designed to investigate the process of bone formation caused by implantation of octacalcium phosphate (OCP) in rat tibiae.Methods: We used 25 young male Sprague–Dawley rats. A full thickness standardized trephine defect, 3-mm in diameter, was surgically created on the superior end of right and left tibia. Amount of 6-μg synthetic octacalcium phosphate was implanted into a bony defect on the right tibia as an experimen...

The aim of the research was to determine the efficacy of alfacalcidol (Alpha D3 Teva) in the treatment of women with postmenopausal osteoporosis and vitamin D deficiency.Methods: 20 women with systemic postmenopausal osteoporosis were examined. All patients had vitamin D deficiency (the average level of 25(OH)D in blood serum was (37.16 (24.9, 45.1)) nmol/l). Alfacalcidol was prescribed for 12 month in doses 1 μg. duration of observation was 12 mont...