Bone Abstracts

An increasing amount of scientific evidence suggests that western diet is a risk factor for osteopenia and osteoporosis. Indeed, metabolic acidosis, occurring after high levels of protein intake, may adversely impact on the skeleton by disrupting calcium metabolism, and leads to a decrease of bone mineral density (BMD). Currently, the prevention and treatment of osteopenia and osteoporosis are mainly based on lifestyle modifications (i.e. exercise, quitting smoking and ensurin...

Non-unions and critical size defects (CSD) are major orthopedic challenges. The gold standard for CSD treatment, bone grafting, is associated with several morbidities. Growth factors such as bone morphogenetic proteins (BMPs) have been utilized in clinic. Nevertheless, huge doses are required for therapeutic effects. Endogenous BMP antagonists, such as Noggin, could be inhibited using small interfering RNA (siRNA) to increase the bioavailability of BMPs and accelerate bone hea...

Objectives: To assess the safety, tolerability and pharmacokinetic (PK) profile of single and multiple doses of TA-46 administered subcutaneously to healthy volunteers.Methods: This was a double-blind, randomized, placebo-controlled trial in a total of 72 subjects. Cohorts of 8 subjects were randomised to receive either TA-46 or placebo in a 3:1 ratio in single ascending dose (SAD) and multiple ascending dose (MAD) cohorts. SAD doses were 0.3, 1, 3, 10 a...

Objectives: We evaluated role of disease activity and genetic factors in fractures predisposing among juvenile idiopathic arthritis (JIA) children.Methods: Bone mineralization parameters were detected by dual-energy X-ray absorptiometry of lumbar spine L1–L4 in 197 (81 boys and 116 girls) JIA children. Bone biochemical markers included osteocalcin, C-terminal telopeptides, parathyroid hormone (PTH), Ca, Ca++, P, tota...

Introduction: There are several disadvantages with the present carriers used in rhBMP-2 products including risk for immunological response, inefficient release and poor handling properties. Our aim was to examine the release of rhBMP-2 from a bisphosphonate-linked hyaluronan hydrogel with the hypothesis that it would cause a slower release.Methods: Triplicates of hydrogels with rhBMP-2 and with (HA-BP) or without (HA) bisphosphonate were prepared, after ...

Background: Cancer is one of the leading causes of death worldwide. Natural products have been regarded as important sources of potential chemotherapeutic agents. In this study, we evaluated the antiproliferative activity of oleuropein, an olive oil compound traditionally found in the Mediterranean diet.Design and Methods: The antiproliferative activity on two human osteosarcoma cell lines (MG-63 and Saos2) was evaluated in vitro using the MTT c...

Ca2+ signaling and NFATc1 activation are essential for RANKL-induced osteoclast differentiation through the induction of Ca2+ oscillation, calcineurin activation, and translocation of NFATc1 into the nucleus. Homer proteins are scaffold proteins that have been proposed to modulate multiple Ca2+ signaling proteins, including inositol 1,4,5-triphosphate receptors, ryanodine receptors, transient receptor potential channels. In this study, we inves...

Objective: Transfusion dependent thalassemia (TM) patients have routinely been placed on vitamin D supplementation due to their increased risk of osteoporosis, as well as their high rates of vitamin D deficiency (serum 25 hydroxyvitamin D (25-OHD) <11 ng/ml) and insufficiency (25-OHD <30 ng/ml). Furthermore, recent studies have linked 25-OHD levels to hypercalciuria and nephrolithiasis in TM. The objective of this study is to determine the effect of vitamin D supplemen...

Aim: To determine the response to treatment, clinical and instrumental features in children with partial GH deficiency (pGHD) and severe GHD (sGHD).Methods: We examined retrospectively 30 children with isolated GHD (stage on Tanner 1) in the Endocrinological department of University hospital (Minsk) over 2004–2012 years. Group 1 (G1) – children with pGHD (n=5) mean±S.D., age 6.3±1.4 years; group 2 (G2) – s...

Objectives: Idiopathic hypercalciuria may infer not only an increased risk of nephrolithiasis but may also be associated with reduced bone mineral density (BMD) in adults. However, little is known about relationships between hypercalciuria, oxaluria, urolithiasis, citraturia and fracture risk in children. The aim of this cross-sectional study was to evaluate associations between hypercalciuria, urinary oxalate and citrate, BMD and fractures in hypercalciuric children.<p cl...