Bone Abstracts

Objectives: To establish the correlations between the body composition, somatotypes and average bone mineral density (BMD) and bone mineral content (BMC) in young (17–18 y.o.) male living in Donbass region (Ukraine).Materials and methods: Anthropometric and skinfold measurements were carried out. Estimations of the calcaneal BMD (g/cm2) and BMC, (r), estimated on ALOKA-5.0 DXA machine among 156 male were done. Total body fat perc...

Objective: Sclerostin, product of the SOST gene, is an important determinant of bone formation and resorption. Rett patients, frequently present marked decreases in bone mineral density (BMD) beyond that expected from disuse atrophy. However, sclerostin has not been yet examined in Rett subjects as a potential mediator of impaired bone metabolism.Methods: This study aimed to investigate whether there is any associations between sclerostin levels, body co...

Children with chronic gastroduodenitis (CGD) have decreased absorption of nutrients, minerals particularly, which can influence on bone strength and linear growth.Objectives: We evaluated bone mineral density (BMD) in children with CGD and compared with healthy individuals.Methods: BMD was measured in 97 children aged 5–13 years by lumbar spine DXA (DPX MD+, Lunar) with pediatric reference database. BMD was evaluated according...

Arterial stiffness or pulse wave velocity (PWV) is increasingly recognized as a strong predictor of future cardiovascular events and all cause mortality. Literature date indicate a relationship between vitamin D (25-OHD) deficiency and arterial stiffness in isolated systolic hypertension (ISH), but it is still unclear how 25-OHD deficiency may contribute to functional changes of the arterial wall in hypertensive patients. This study aimed to evaluate the relationships between ...

Postmenopausal women with early stage hormone-receptor-positive breast cancer (EBC) are standardly treated with aromatase inhibitors (AIs). However, one side-effect of AIs treatment is a decrease in bone mineral density (BMD) and an increased risk of fracture. The objectives of this study were to examine: i) changes in bone formation (N-terminal propeptide of type I procollagen; PINP) and bone resorption (cross-linked C-telopeptides of bone type I collagen; CTX) markers, as we...

Background and aims: Low bone formation is the main pathogenic mechanism of osteoporosis in primary biliary cirrhosis (PBC). Sclerostin, an inhibitor of the Wnt pathway, is involved in the regulation of osteoblastogenesis and little is known about its role in the development of bone disease in PBC. Thus, we evaluated the circulating levels of sclerostin and its relationship to bone mass, the parameters of mineral metabolism and liver disease severity.Met...

Background: Pathophysiological calcification in the vasculature is a risk factor for cardiovascular disease (CVD). CVD are among the most common causes of death in patients with chronic kidney disease and crucial for kidney transplantation (RTX) outcomes.Aim: The aim of this study is to identify differences in the pattern and the onset of expression of regulators of calcification (RC) in atherosclerosis (AS) and media sclerosis (MS).<p class="abstext...

Introduction: The recent studies show high prevalence of vitamin D deficiency and insufficiency all over the world. Vitamin D deficiency can cause serious problems such as rickets in children and osteomalacia in adults.The aim of the study was to determine the influence of vitamin D deficiency on bone mineral density.Methods: There were examined 304 children aged 10–18 years. The boys consisted 53%. The average age of boys was...

The aim of the study was to evaluate the appendicular lean mass depending on the dietary protein intake in the Ukrainian postmenopausal women.Materials and methods: The study involved 63 women aged 52–89 years, who, depending on their ages, were divided into groups: 52–59 years (n=9), 60–69 years (n=26), 70–79 years (n=21), 80–89 years (n=7). To assess the dietary habits of women, we used the t...

Camurati-Engelmann disease (CED) is a rare autosomal dominant bone disease with transforming growth factor-β1 (TGFβ1) gene mutation. In order to expand our limited knowledge of Chinese CED patients, we reported eight Chinese families (11 patients) diagnosed with CED. The study was approved the Department of Scientific Research of Peking Union Medical College Hospital. All the patients were evaluated genetically, clinically, biochemically and radiographically...