Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0004p32 | (1) | ICCBH2015

Characteristics of Malawian children undergoing corrective bone surgeries of rickets-like lower limb deformities

Braithwaite Vickie S , Greenwood Carla L , Bishop Nicholas J , Cashman John , Prentice Ann

Cases of non-vitamin D deficiency rickets have been reported in African countries including The Gambia, South Africa and Nigeria where the likely aetiology is a chronically low dietary calcium intake. Additional aetiological factors in Gambian studies are iron deficiency leading to a disruption in phosphate metabolism.Surgical correction of pathological rickets-like lower-limb deformities is the most common operation performed at the Beit Cure Orthopaedi...
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ba0004p33 | (1) | ICCBH2015

In utero effects of iron status on infant fibroblast growth factor-23 and mineral metabolism

Braithwaite Vickie S , Prentice Ann , Darboe Momodou K , Prentice Andrew M , Moore Sophie E

Fibroblast growth factor-23 (FGF23) is a bone derived phosphate-regulating hormone which is elevated in hypophosphataemic rickets. Recent findings demonstrate iron deficiency as a potential mediator of FGF23 expression and murine studies have shown in utero effects of maternal iron deficiency leading to increased FGF23 concentration and disordered bone development (Clinkenbeard. JBMR 2013). Children with rickets in rural Gambia, West Africa, have high prevalences of i...
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ba0005p41 | Bone biomechanics and quality | ECTS2016

Investigation of the potential link between mechanosensory proteins PC1/PC2 and craniosynostosis

Katsianou Maria , Piperi Christina , Korkolopoulou Penelope , Themistocleous Marios S , Basdra Efthimia K , Papavassiliou Athanasios G

Background: Skull development is a tightly regulated process that occurs along the osteogenic interfaces of the cranial sutures that allow rapid bone formation at the edges of the bone fronts. Premature closure of cranial sutures can result in pathological conditions such as Craniosynostosis. The mechanosensory proteins Polycystin 1 (PC1) and 2 (PC2) have been shown to regulate skeletal development and potentially suture formation.Aim: The aim of study w...
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ba0006oc25 | (1) | ICCBH2017

Biochemical and physical function outcomes after 5 years of treatment with asfotase alfa in adolescents and adults with hypophosphatasia: phase 2 study results

Kishnani Priya S. , Rockman-Greenberg Cheryl , Denker Andrew E. , Moseley Scott , Whyte Michael P.

Objective: To evaluate safety and efficacy after 5 years of treatment with asfotase alfa in adolescents and adults with hypophosphatasia (HPP) in a Phase 2, open-label, randomized, dose-ranging study (NCT01163149).Methods: Treatment with subcutaneous asfotase alfa 0.3 or 0.5 mg/kg per d was compared with no treatment (control) for 6 months in patients aged 13–66 years. After 6 months, all patients (treatment and control groups) received active treat...
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ba0006p068 | (1) | ICCBH2017

Craniosynostosis can occur in children with nutritional rickets

Forestier-Zhang L , Arundel P , Cross R Gilbey , Mughal M Z , Offiah A C , Cheung M S

Background: Severe vitamin D deficiency (VDD), is a common disorder, which has complications including rickets, hypocalcaemia, hypotonia, delayed development and cardiomyopathy. Although nutritional rickets associated craniosynostosis has been reported, there is little awareness of this or knowledge about its clinical course or severity. We present five cases of late onset craniosynostosis in association with nutritional rickets.Clinical presentation: Th...
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ba0001pp193 | Cell biology: osteoblasts and bone formation | ECTS2013

Normal human osteoblast cells exerts an adaptive effect towards moderate hypothermia by retaining bone metabolism and cellular function in vitro

Aisha Mohd Din , Nor-Ashikin Mohamed Noor Khan , Sharaniza Ab. Rahim , Nawawi Hapizah , Kapitonova Marina , Froemming Gabriele Ruth Anisah

Over the years, it has been demonstrated that the ability to maintain body core temperature in older adult’s declines with age. Temperature is a vital physical factor for cell growth and a downshift in core body temperature (<37 °C) might have a direct affect on maintaining bone density or repair fractures. Disruption in any of the cellular processes involved in bone remodelling leads to a net loss of bone mineral density and bone loss. Therefore our study looked...
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ba0001pp490 | Other diseases of bone and mineral metabolism | ECTS2013

Fracture predictors in patients with endogenous cortisol excess

Belaya Zhanna , Dragunova Natalia , Rozhinskaya Liudmila , Dzeranova Larisa , Melnichenko Galina

Objective: Of this study was to investigate the factors influencing fractures in endogenous Cushing’s syndrome (CS) of various etiologies.Materials and methods: The retrospective data of patients, who had received treatment due to endogenous CS, (2001–2011 years) was evaluated. All enrolled patients underwent standard spinal radiographs in lateral positions of the vertebrae Th4-L4. Recent low traumatic non-vertebral fractures were recorded in t...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0002oc15 | Diagnostics | ICCBH2013

Bone health index: Swiss children have less in the bank than a generation ago

Thodberg Hans Henrik , Martin David D , Caflisch Jon , Jenni Oskar

Objective: The aim of this study is to compare the bone health index (BHI) for healthy Swiss children born in 1955 with healthy Swiss children born a generation later.Method: BHI is derived from the cortical thickness in the three middle metacarpals. It is determined with the BoneXpert medical device, which automatically analyses a standard bone age hand radiograph. The measurement result is independent of the sharpness of the image. The image data are f...
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ba0002oc17 | Diagnostics | ICCBH2013

Determinants of bone mineral density in long-term adult survivors of childhood cancer

Klap B C , te Winkel M L , den Hoed M , van Waas M , Neggers S J C M M , Boot A M , Pieters R , Pluijm S M F , van den Heuvel-Eibrink M M

Objectives: Osteopenia is a complication of childhood cancer treatment but it is unknown to which extend this occurs in adult survivors, and which subgroups are at risk. We examined bone mineral density (BMD) and assed the relative importance of potential determinants of low BMD in very long-term adult survivors of childhood cancer.Methods: The single-center cohort study included 410 adult CCSs (median age at diagnosis: 6.6 years (range: 0–17 years)...
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