Bone Abstracts

Background and aims: Vitamin D supplementation has the potential to alleviate the cardiovascular damage in diabetic patients. The present study was designed to evaluate long term impact of high doses of vitamin D on arterial properties, glucose homeostasis, adiponectin and leptin in patients with type 2 diabetes mellitus.Methods and results: In randomized, placebo-controlled study 47 diabetic patients were assigned into two groups: Group 1 received oral ...

Objectives: To assess the vitamin D nutrition status of healthy children in the age group 2–5 years and to assess the daily dietary calcium intake of these children.Methods: A total of 100 healthy children (age group 2–5 years) were studied in this cross sectional study. Dietary calcium and energy intake was estimated using 24 h dietary recall method. Average sun exposure over last 3 days was assessed by calculating u.v. score. Biochemical para...

Objectives: The aim of this study was to assess the impact of age, sex, location of injury, physical activity, dietary intake of calcium and vitamin D on injury outcome in otherwise healthy children.Materials: This study was a cross-sectional prospective study. Children aged 6 to 15 years who presented to the Emergency Department of a single tertiary paediatric referral hospital were recruited. Children were included it they were known not to have underl...

Background: Hereditary pseudovitamin D-deficiency rickets, also known as vitamin D-dependent rickets type I, with an autosomal recessive inheritance, is caused by mutations in CYP27B1. It is characterized clinically by hypotonia, weakness, growth failure, and hypocalcemic seizures in early infancy. The patients also have hypocalcemia, radiologic findings typical of rickets, elevated serum parathyroid hormone concentrations, and generalized aminoaciduria. We present follow-up o...

Objectives: Obese adults commonly have vitamin D deficiency and secondary hyperparathyroidism prior to bariatric surgery. Whether similar metabolic abnormalities exist in morbidly obese adolescents is not known. This study investigated the prevalence of vitamin D deficiency and evaluated the relationship between vitamin D and parathyroid hormone (PTH) in morbidly obese adolescents undergoing evaluation for bariatric surgery.Methods: A cross-sectional stu...

Calcium (Ca) and vitamin D nutritional status effects on oral health were evaluated in 85 healthy women aged between 20 and 30 years (24.6±0.4). They attended the first year of the Nutrition Carrier at the Private University (ISALUD, Buenos Aires, Argentine). Usual Ca intake (CaI) was determined by a food-frequency questionnaire that included consumption of dairy products and calcium-enriched foods. Blood samples were obtained in a fasting state in winter: the end of Augu...

Objectives: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spinal deformity associated with low bone mass. Our previous clinical trial demonstrated the anabolic bone effect of vibration treatment (VT) at the femoral neck in AIS subjects. The therapeutic effect was more pronounced in those with optimal serum 25(OH) Vit-D level (>40 nmol/l). To investigate possible factor interaction between Vit-D and VT on their anabolic bone effects, this in-vitro...

Objectives: Randomised controlled trials (RCTs) of vitamin D to reduce the incidence of infections among children have yielded variable results (Holland, 2012; Camargo, 2012). We performed a RCT of supplementation with vitamin D3 (cholecalciferol) along with calcium or supplementation with zinc in order to assess their effect on the incidence of infections in rural Indian school children.Methods: A double-blind, placebo-controlled RCT was conducted on 46...

Objectives: Erythropoietic protoporphyria (EPP) is a rare disease with cutaneous photosensitivity, in which patients avoid sun exposure and use sunscreen. Our purpose was to study bone mineral density (BMD), serum 25-OHD levels and other mineral parameters, to evaluate the impact of these measures in the follow-up of EPP patients.Patients and methods: A ten EPP patients (median age 25; range 22–55, four males and six females), were study for clinica...

Lack of Klotho, the co-receptor for the bone-derived hormone fibroblast growth factor-23 (FGF23), leads to a severe impairment in bone mineralization in mice. However, the mechanisms underlying the Klotho deficiency-associated defects in bone mineralization are still poorly understood. Here, we sought to elucidate the vitamin D independent role of Klotho in bone mineralization. To ablate increased vitamin D signaling in Klotho knockout mice (Kl−/−), we c...