Bone Abstracts

Introduction: Hydrogels has demonstrated efficacy as carriers for growth factors. Our aim was to investigate the effect of curing-time of modified hyaluronan on bone formation.Methods: Hydrogels with rhBMP-2 were cross-linked for 14 and 3 days, 5 h or 1 min before injection. Preformed gels were injected s.c. in 5 rats, the rats were killed after 5 weeks. Explanted samples were radiographed and scanned by pQCT.Results: Bone formatio...

Exercise can prevent or mitigate musculoskeletal challenges of aging. To prescribe an effective /osteogenic exercise program the individual’s muscle strength, bone mineral density, and cardiovascular status would need to be considered.Osteoporotic vertebral fractures and resulting mal-posture create musculoskeletal challenges that cannot be met with pharmacotherapy alone. Bone loss, disequilibrium along with pain can increase inactivity, and further...

Drug treatment for osteoporosis typically begins with an oral bisphosphonate, regardless of initial BMD or fracture risk and decisions to continue or change treatment are often based on evidence of ‘response’ to treatment based on changes in BMD, bone turnover markers, and occurrence of fractures. Treatment is often continued for fixed periods of time, perhaps stopped for a ‘drug holiday’.This approach differs from preventive therapy ...

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are systemic, immune-mediated diseases. RA’s main targets are the peripheral joints while AS has the axial skeleton and enthesis as the principal affected areas. RA is characterized by bone erosions and impaired repair whilst AS is typified by bone overgrowth. The causes for these differences are not yet understood; however we hypothesize that AS patients’ monocytes receive reduced osteoclastogenic stimuli and...

Biographical DetailsDr Leanne M Ward is an Associate Professor of Pediatrics at the University of Ottawa where she holds a Research Chair in Pediatric Bone Health. She is the Medical Director of the Pediatric Bone Health Clinical and Research Programs at the Children’s Hospital of Eastern Ontario (CHEO) and a pediatric endocrinologist within the Division of Endocrinology and Metaboli...

Osteosarcoma is the most common primary bone-derived tumor. However, the pathogenic molecular mechanism(s) underpinning osteosarcoma development and metastasis remain elusive. The polycystins PC1 (polycystin-1; encoded by PKD1) and PC2 (polycystin-2) are central players in mechanotransduction, a process that can influence all steps of the invasion/metastasis cascade. Recent studies from our laboratory provided, for the first time, a direct link between mechanosensing polycysti...

Biographical DetailsBjörn BusseBjörn Busse is currently head of a ‘Emmy Noether Research Group’ (eq. Assistant Professor) which is a prestigious 5 year-program run by the German Research Foundation (DFG). The group of Björn is hosted by the Department of Osteology and Biomechanics at the University Medical Center Hamburg-Epp...

Biographical DetailsDr Melita IrvingDr Melita Irving is a consultant in clinical genetics and joint head of service at Guy’s and St Thomas’ Hospital NHS Foundation Trust with the Evelina London Children’s Hospital. She is a trained general geneticist and sub-specialises in skeletal dysplasia, particularly achondroplasia and other gene...

Biographical DetailsFrank RutschFrank Rutsch is a consultant and Associate Professor in Pediatrics at Münster University Children’s Hospital, Münster, Germany. He graduated from Münster University Medical School in 1992 and took part in the Pediatric residency program in Dresden University and Dortmund Municipal Hospital, Germany...

Biographical DetailsLeanne WardDr Leanne Ward is an Associate Professor of Pediatrics at the University of Ottawa where she has held a Research Chair in Pediatric Bone Health since 2010. She is the Medical Director of the Pediatric Bone Health Clinical and Research Programs at the Children’s Hospital of Eastern Ontario. Dr Ward’s research ...