Bone Abstracts

Background: Women with breast cancer (BC) are at high risk for fracture due to the deleterious impact of BC therapies on bone. In China, BC survival is improving as screening and treatment programs expand, however no guidelines exist to prevent BC treatment-induced bone loss. We sought to evaluate the scope of this problem among BC survivors receiving care at a large cancer referral hospital in China.Methods: Women were invited to participate in this cro...

Site-specific osteoclasts (OC) and OC-like cells from different pathologies exhibit heterogeneity e.g. in the resorption machinery, influence of anti-resorptive drugs and response to local or systemic hormones e.g. PTH. The explanation for this is not known but different precursors, local regulation through osteoblasts (OB), osteocytes and extracellular matrix (ECM) could be involved. To study these differences a simple and reproducible cell model is an advantage in pre-clinic...

Osteolytic bone disease (OBD) is a frequent complication of multiple cancers, such as multiple myeloma. OBD is due to the disruption of balanced bone remodelling, with higher bone resorption due to increased osteoclast activation and osteoblast inhibition. Lectin–glycoprotein interactions have been implicated in osteoclast formation. In the current study, we set out to identify lectins that are involved in osteoclastogenesis and to study their role in this process. We ant...

Introduction: Genetic disorders are usually characterised by subjective morphological traits. Mouse models should represent the human situation but it is difficult to translate morphology traits from one species to another. Thus, there is a demand to objectively assess morphological traits. Geometric morphometrics is a mathematical tool to evaluate morphology based on normalised three-dimensional coordinates. Here we use geometric morphometrics to compare the morphology of <em...

Skeletal strength, maintained through bone remodelling, is regulated through complex communication networks between bone cells and other tissues including endocrine cells. Bone also functions as an endocrine organ in its own right. The peptide hormone amylin (or Islet Amyloid Polypeptide (IAPP)), has links to both bone and energy metabolism. A member of the calcitonin family of peptides, it is co-secreted with insulin from pancreatic β-cells and is linked with diabetes-as...

Background: Advancing maternal age at childbirth has been associated with a higher risk of pregnancy complications and with adverse short-term and long-term offspring health outcomes, but little is known about the effects of increasing maternal age on offspring bone acquisition.Objective: To investigate associations of maternal age at childbirth with offspring bone parameters in healthy men at the age of peak bone mass.Methods: We ...

Background and Aim: Smoking increases fracture risk and contributes to COPD-associated osteoporosis. However, its impact on bone metabolism is largely unknown. We thus aimed to determine the effect of smoking cessation on bone metabolism.Subject and Method: In this prospective study, we recruited 29 healthy Japanese male subjects with smoking habit (37.7±8.2 years old, 16.9±11.3 pack years). Pulmonary function test was done before smoking cessa...

Background: Postmenopausal women are at high risk for osteoporosis, and early adoption of osteoporosis-preventative behaviours, such as physical activity and dietary calcium intake, can help mitigate this risk. Behavioural studies have shown that knowledge and health beliefs are key factors associated with adoption of healthy behaviours. There are few such studies regarding osteoporosis in South America. Our aim was to conduct an exploratory study evaluating osteoporosis-relat...

Delayed healing of stress fractures constitutes a significant clinical problem causing prolonged pain and disability for the patients affected. All stress fractures exhibit Bone Marrow (edema) Lesions (BMLs) with and without fracture lines on MRI, and in cases of delayed union these lesions persist. Previous studies on transient osteoporosis and osteoarthritis have demonstrated that bisphosphonates can reduce BMLs. We therefore wanted to test, whether treatment with iv. zoledr...

Paget’s disease of bone (PDB) is a common disease characterised by focal abnormalities in bone turnover. Previous GWAS identified a susceptibility locus for PDB on chromosome 15q24 tagged by a coding SNP rs5742915 (p.Phe645Leu) located in PML. The aim of this study was to fine map this locus to identify functional genetic variants that predispose to PDB using targeted DNA sequencing and functional analysis in bone cells.A 200 kb region surr...