Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0005cabs.oc3.4 | Oral Communications | ECTS2016

Anti-sclerostin treatment prevents multiple myeloma bone disease and reduces tumour burden

McDonald Michelle , Reagan Michaela , Terry Rachael , Pettitt Jessica , Le Lawrence , Mohanty Sindhu , Kramer Ina , Kneissel Michaela , Brooks Daniel , Cheng Tegan , Little David , Bouxsein Mary , Rosen Cliff , Ghobrial Irene , Croucher Peter

Multiple myeloma is characterized by extensive bone marrow tumour and destructive osteolytic lesions. Both increased bone resorption and suppressed bone formation result in lesions and pathological fractures. Anti-resorptive therapies prevent further bone loss but patients continue to fracture, arguing for new therapies which increase bone strength. Anti-Sclerostin (Anti-Scl) is a potent stimulator of bone formation, is currently in clinical trials for osteoporosis, however it...
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ba0005p444 | Other diseases of bone and mineral metabolism | ECTS2016

Deep characterization of a zebrafish model for dominant osteogenesis imperfecta

Tonelli Francesca , Gioia Roberta , Biggiogera Marco , Fisher Shannon , Leikin Sergey , Schinke Thorsten , Rossi Antonio , Forlino Antonella

Dominant osteogenesis imperfecta (OI) is a bone disease mainly caused by collagen type I mutations and characterized by bone fragility and growth delay. Nowadays no definitive cure is available. A zebrafish OI model (Chihuahua) carrying an heterozygous G574D substitution in the α1 chain of collagen type I was generated by ENU mutagenesis and is available in our laboratory. Control (WT) and mutant (Chi+/−) fish growth was followed up from day 1 post fertilization to ...
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ba0001ni3 | (1) | ECTS2013

Bisphosphonate influence on bone quality at molecular level: study of human jaw bone sequesters by Raman microspectroscopy

Olejnik Cecile , Falgayrac Guillaume , During Alexandrine , Vieillard Marie-Helene , Maes Jean Michel , Cortet Bernard , Penel Guillaume

see PP38....
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ba0001pp38 | Bone biomechanics and quality | ECTS2013

Bisphosphonate influence on bone quality at molecular level: study of human jaw bone sequesters by Raman microspectroscopy

Olejnik Cecile , Falgayrac Guillaume , During Alexandrine , Vieillard Marie-Helene , Maes Jean Michel , Cortet Bernard , Penel Guillaume

Bisphosphonates (BP) are used as anti-resorptive drugs in benign (osteoporosis) and malignant (myeloma, bone metastasis) bone diseases. Their high affinity for biominerals allows prolonged storage within bone. However information about molecular impact of BP on bone quality are missing. Better understanding of BP properties to optimize their clinical use is needed. The aim of this study was thus to investigate human bone physicochemical changes upon BP uptake.<p class="abs...
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ba0001pp126 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Vitamin D: light side and best time of sunshine in Riyadh, Saudi Arabia

Alshahrani Fahad , Almalki Mussa , Aljohani Naji , Alzahrani Abdullah , Alsaleh Yossef , Holick Michel

Low levels of 25-hydroxyvitamin D have been documented among inhabitants of the wider Middle East and North African countries. Sunlight has long been recognized as a major provider of vitamin D. In this study we aimed to determine the optimum time for sun exposure in the Central region of Riyadh, Saudi Arabia. Ampoules containing 7-dehydrocholesterol in ethanol were exposed to sunlight every hour starting from sunrise until sunset in July and December. Our results demonstrated...
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ba0007p166 | (1) | ICCBH2019

The ketogenic diet and bone density: a retrospective longitudinal cohort study

Draaisma Jos , Hampsink Brieke , Willemsen Michel , Linders Miel , van Houdt Nicole

Background: The Ketogenic Diet Treatment (KDT) is a well-established intervention for intractable childhood epilepsy and the first choice treatment for Gluccose-1-transporter-deficiency-syndrome and Pyruvate-dehydrogenase-complex deficiency. During long-term follow up of children treated with KDT an increased incidence of bone fractures has been found. However, the exact contribution of KDT to a decreased BMD remains unclear. Prophylactic supplementation with calcium and vitam...
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ba0006lb18 | (1) | ICCBH2017

Occurrence of vitamin D and vitamin K deficiency in children with low-energy fractures

Karpinski Michal , Chojnowska Sylwia , Maresz Katarzyna , Milewski Robert , Popko Janusz , Badmaev Vladimir

Objective: Bone fractures are very common in children and their number is growing every year. Vitamin D has a proven role in the prevention of fractures. In the recent study, we have shown that children with low-energy fractures have significantly lower vitamin D blood levels compared to the children without fractures. Our data indicate that higher levels of vitamin D reduced the risk of fracture by 1.06 times (P<0.0005).Past decade has seen...
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ba0004oc12 | (1) | ICCBH2015

A zebrafish osteogenesis imperfecta model: a new tool to develop novel pharmacological treatments

Gioia Roberta , Tonelli Francesca , Carra Silvia , Cotelli Franco , Bianchi Laura , Gagliardi Assunta , Bini Luca , Biggiogera Marco , Leikin Sergey , Fisher Shannon , Rossi Antonio , Tenni Ruggero , Forlino Antonella

Objectives: Osteogenesis imperfecta (OI) is a bone disease mainly caused by collagen type I mutations and characterized by bone fragility. No definitive cure is available and the search for novel treatments is necessary. The small teleost D. rerio is particularly appealing for drug screening approaches. A zebrafish OI model (Chihuahua) carrying in heterozygosis the G574D substitution in the α1 chain of collagen type I is available. To use this model for ...
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ba0003pp375 | Other diseases of bone and mineral metabolism | ECTS2014

Osteoprotegerin and bone-like vascular calcification are predictive markers of vulnerable carotid plaques

Heymann Marie Francoise , Davaine Jean Michel , Laperine Olivier , Merlini Thierry , Guyomarch Beatrice , Chatelais Mathias , Guilbaud Florian , Brennan Meadhbh Aine , Heymann Dominique , Goueffic Yann

Vascular calcification has a marked impact on arterial heterogeneity and plaque stability. Based on a cohort of 116 patients (carotid and femoral endarterectomies), the aim of the present study was to determine the influence of the bone-like vascular calcification and of osteoprotegerin (OPG) on plaque stability.Seventy-three carotid and 43 femoral plaques along with plasma were harvested and analyzed in a single center study. The presence of osteoid met...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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Bone Abstracts
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