Bone Abstracts

Introduction: Bisphosphonates (BPs) are currently the mainstay of treatment in osteoporosis; however, the complex dosing regimens might interfere with long-term adherence, which provided the rationale to develop BPs with less-frequent dosing schedules. Minodronate (MIN 50 mg), a highly potent new-generation BP, is the first BP available as a once-monthly oral regimen in Japan. The aim of the present study was to investigate patient preference for, and adherence to, MIN 50 mg i...

Bones’ fracture resistance is achieved in vivo by adaptation to habitual loading. Aged bone can adapt to exercise1 but in female rodents ageing impairs the adaptive response to artificial loading2,3. This inconsistency led us to investigate whether treadmill exercise, sufficiently mild to not itself stimulate new bone formation, could rescue aged bone’s diminished response to artificial loading.Young adult 17-week...

Background: Autosomal dominant hypocalcaemia (ADH) is caused by activating mutations of the calcium sensing receptor (CaSR). Symptomatology ranges from asymptomatic hypocalcaemia to paraesthesia, tetani, laryngospasm and seizures. This is the first report of congenital hyperinsulinism (CHI) in a child with ADH.Presenting problem and clinical management: A female infant, born at term from non-consanguineous parents. She presented on D2 with persistent asy...

Osteogenesis Imperfecta (OI) is a genetic condition which alters collagen biosynthesis(1). Prevalence is estimated at 1 in every 15, 000 births. It is a disorder with a wide spectrum of severity, with cases ranging from the extremely mild to those of perinatal mortality. Typical features include bone fragility; short stature; long bone deformity and persistent blue sclera(2). Although currently there is no cure for OI, with the input of a multidisciplinar...

Introduction: Hydrogels has demonstrated efficacy as carriers for growth factors. Our aim was to investigate the effect of curing-time of modified hyaluronan on bone formation.Methods: Hydrogels with rhBMP-2 were cross-linked for 14 and 3 days, 5 h or 1 min before injection. Preformed gels were injected s.c. in 5 rats, the rats were killed after 5 weeks. Explanted samples were radiographed and scanned by pQCT.Results: Bone formatio...

Objective: To investigate i) the analytic stability of PTH in venous blood specimens in serum tubes processed at different time intervals after collection compared to immediately processed blood samples collected in K2EDTA tubes, and ii) whether storage of samples in serum tubes for 5 years at −20 °C had an effect on stability of PTH.Methods: Venous blood samples were collected from ten healthy Caucasian females. One K2EDTA tube and three seru...

Objective: Zoledronic acid (Zol) has been demonstrated to be an effective therapy to treat postmenopausal osteoporosis (PMO) in Chinese women in a 12-month post-marketing observational study (ZOOM study). As an I.V. bisphosphonates, Zol are exclusively excreted via the kidneys. We present a report of the renal function and safety data of once-yearly Zol 5 mg treatment.Subjects and methods: A total of 373 PMO patients from 30 different centers in China wi...

Low bone density in younger women is often due to underlying conditions such as eating disorders, premature ovarian failure or glucocorticoid treatment. It may also be due to genetically low peak bone mass.In general, absolute fracture risk in young women is low, even in the context of low bone density. Management should begin with treatment of underlying causes where possible, and lifestyle modification where appropriate.The evide...

Objective: The purpose of this study was to determine the impact of age on the ultrastructural, histological, biomechanical, and biochemical changes of bone tissue in rats.Methods: The study included 24 female rats of two age groups: Group A (Young) of 5-month old rats and Group B (Old) of 18-month old rats. Radiomorphometric assessment of the hydroxyapatite was used to investigate the ultrastructure of the alveolar bone tissue. Biomechanical and biochem...

Objectives: This study is aimed at investigating of histological features of mandibular condylar cartilage (MCC) in rats after 2-month inhalation of epichlorohydrin (ECh) vapors and administration of thiotriazoline (Th) and Echinaceae tinctura (ET) as medication.Methods: The experiment involved 420 male rats (young, adult and senile). The animals were split into the groups: 1st group comprised control animals, the 2nd group comprised the animals...