Bone Abstracts

Background: It is well established that Asians have lower levels of vitamin D (25OHD) when compared to Caucasians. Vitamin D binding protein (DBP) levels are also lower in some races than in Caucasians.Objectives: i) To find out whether DBP is lower in Asians; ii) To find out whether free 25OHD is lower in Asians; iii) To find out whether PTH is increased in Asians and interpret this in relation to 25OHD levels and iv) To find out whether the increment i...

Objectives: Murine studies have shown that iron deficiency during pregnancy can cause abnormal phosphate and bone metabolism in offspring by elevating concentrations of fibroblast growth factor-23 (FGF23). FGF23 exists in plasma as an intact phosphate- and vitamin D-regulating hormone and its C-terminal fragment, a cleavage product that possibly antagonises the intact hormone. These findings are pertinent to low-income countries, where the prevalence of iron deficiency in preg...

Objectives: Nutritional rickets results from the interaction of poor vitamin D status and limited calcium intake. Vitamin D requirements are greater in children with limited intake of calcium. We sought to determine the serum 25-hydroxyvitamin D [25(OH)D] concentration that can prevent rickets in calcium-deprived Nigerian children.Methods: We reanalyzed data from a case-control study of Nigerian children with active rickets (cases) and age-, sex-, and we...

Background: Vitamin D status is associated with bone health. Vitamin D deficiency leads to decreased bone formation and increased bone resorption. 25-hydroxyvitamin D (25(OH) D), parathyroid hormone (PTH) levels in children could affect bone turnover, and in turn, the bone markers should reflect vitamin D condition. In children the relationships among 25(OH) D, PTH and bone turnover markers are remain.Objective: To explore the associations among serum 25...

Background: Rickets is a disorder of the growing child arising from impaired mineralisation of the growth plate and osteoid. The most common cause of NR in the UK is thought to be secondary to vitamin D deficiency [VDD; serum 25-hydroxyvitamin D (25OHD) <25 nmol/l], although in some African & South Asian countries dietary calcium deficiency (DCaD) by itself, or together with VDD is an important cause of NR (Ann Trop Paediatr. 2006;26:1–16). Currently, the data on ...

Introduction: Giant cell tumour of the bone (GCTB) is a benign, locally aggressive tumour whose neoplastic stromal cells express receptor activator of nuclear factor kappa-B ligand (RANKL) and activate its receptor RANK on osteoclast-like giant cells. Denosumab (RANKL inhibitor) is an FDA/EMA approved treatment for GCTB in adults and ‘skeletally mature’ adolescents. Safety concerns include oversuppression of bone remodelling, with risk of osteonecrosis of the jaw [ON...

Hypophosphatasia is a recessively inherited disorder with a wide phenotypic manifestation ranging from lethality in neonates to asymptomatic in adults. The severity of the phenotype is largely determined by the nature of the ALPL mutations. We describe a previously asymptomatic adult whose phenotype dramatically changed after he developed renal failure. A 50-year-old man was diagnosed with IgA nephropathy. At age 52 (eGFR 50 ml/min) he suffered his first metatarsal fr...

Introduction: Vitamin D deficiency is common among elderly subjects and is associated with reduced muscle strength. Although vitamin D deficiency is common among Saudi subjects, knowledge about its role in relation to muscle strength and physical performance is lacking. The objectives of the present study are to determine vitamin D status in a sample of randomly selected healthy postmenopausal Saudi women and to investigate the association between their serum 25(OH)D levels an...

Backgrounds: Ossification of the posterior longitudinal ligament (OPLL) is characterized by pathological ectopic ossification of the posterior longitudinal ligament. Development of OPLL induces compression myelopathy or radiculopathy by spinal stenosis and the loss of spinal flexibility by ankylosing spinal hyperosteosis (ASH). Although the etiology of OPLL has not been fully elucidated, systemic and local bone formation factors may play a role in the pathogenesis of OPLL. The...

According various guidelines the basic recommendation in prevention and treatment of postmenopausal osteoporosis (PMO) is adequate intake of calcium (1000– 1300 mg/day) and vitamin D (800–1000 IU/day).Aim: To determine the intake dose of calcium and also the vitamin D saturation in women treated for PMO.Patients and methods: 465 women with PMO, divided into two groups: patients with newly diagnosed osteoporosis (n</em...