Bone Abstracts

Biographical DetailsEleonora Dondossola is a Senior Postdoctoral Fellow in the Intravital Imaging Lab, Koch Center for Applied Research in Genitourinary Cancers, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. She received her PhD in Cell and Molecular Biology from S. Raffaele Vita-Salute University, Milan, Italy, in 2010. Her current research is focused on metastasis...

The purpose of this study is to understand the changes of TBS scores in Asian females by comparing 1990’s and 2010’s DXA images.We have compared the DXA images of 3774 Korean females (age: 20–79) to Japanese (age: 20–79). While Korean DXA images were obtained in 2014 and 2015, Japanese data were obtained in 1996. Participants who have abnormal DXA images or lumbar disease were excluded. TBSiNsight® software (v. 2.1.1, ...

GNAS-Gsalpha based disorders lead to heterogeneous diseases associated with abnormal bone development via two distinct mechanisms. At the level of the growth plate in bones, the PTHrP/PTH1R/Gsalpha/cAMP/PKA/PDE signalling pathway regulates endochondral ossification. PTHrP binds to the PTH receptor (PTH1R) which then couples with the stimulatory G protein (Gsalpha) leading to cAMP formation. cAMP binds to the regulatory 1A subunits (R1A) of the PKA. Upon binding the catalytic s...

Background: Hypercalcemia in childhood is rare, can be of various origin and might go unrecognized until severe signs appear. We demonstrate hypercalcemia of different causes in two infants.Case no 1.: 5-month old girl with failure to thrive, constipation, muscle hypotonia, dehydration, where total calcaemia peaked to 4.25 mmol/l. Low calcium diet, application of glucocorticoids and furosemide resulted in a drop in calcaemia to values below 3 mmol/l and ...

Objectives: Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture, but the etiology of this disposition is unknown. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS.Methods: This was a cross-sectional study of 10 children (9 females) ages 8-18 years, with a clinical diagnosis of ALG...

Background: ‘Play Plans’ are now being routinely used at the NHS England Sheffield Severe, Complex and Atypical Osteogenesis Imperfecta Service (SCAOI) as an intervention designed to enhance early development. These plans are MDT formulated and encompass carefully targeted activities designed to meet the child’s needs at their exact stages of development across five domains; Cognition, Social & Emotional Development, Motor, Adaptive Skills and Communication ...

Objectives: To make a prediction model for septic arthritis on the basis to analyze CRP versus CD64 on neutrophils (nCD64) as an adjunct parameter to Kocher’s criteria to differentiate septic arthritis from transient synovitis.Methods: In this open ended prospective study, children (n=34) below 18 years of either gender (M=22/F=12) below 18 years presenting with acute, new onset, non – traumatic limp or joint pain were enrolled as case...

Objectives: Cross-sectional studies show that exercise may have positive effects on bone outcomes in youth. However, there is no evidence from longitudinal studies, which type of sports can induce improvements in bone acquisition in adolescent athletes. Therefore, this study aimed to investigate the longitudinal differences in bone acquisition and bone metabolism between adolescent males participating in osteogenic (football) and non-osteogenic (swimming, cycling) sports compa...

Objectives: We recently demonstrated that cow’s milk allergic infants who received an amino acid-based formula (AAF) for 16 weeks as oral feeding had adequate mineral status (1). One factor that may negatively affect mineral solubility and bioavailability and hence mineral status, is high gastric pH (2), but data on this in infants are lacking. Therefore, the present study evaluates serum concentrations of phosphorus, calcium and magnesium in a subgroup of infants on AAF ...

Introduction: Hydrogels has demonstrated efficacy as carriers for growth factors. Our aim was to investigate the effect of curing-time of modified hyaluronan on bone formation.Methods: Hydrogels with rhBMP-2 were cross-linked for 14 and 3 days, 5 h or 1 min before injection. Preformed gels were injected s.c. in 5 rats, the rats were killed after 5 weeks. Explanted samples were radiographed and scanned by pQCT.Results: Bone formatio...