Bone Abstracts

In postmenopausal women, estrogen deficiency not only interferes with the metabolism of the bone tissue, but also adversely affects the cardiovascular system and can cause hypertension. Doxazosin is often used in the treatment of resistant hypertension, especially in patients with renal failure and hyperlipidemia. Vasodilator effect of doxazosin is associated with selective blocking of α1 receptors in the smooth muscle cells of resistance arterioles. The results of epidem...

Dietary Ca insufficiency is a common finding, independently of socio-economic status. A low Ca intake (CaI) increases bone turnover leading to bone loss. This effect becomes more important during estrogen withdrawing. We previously found that a mixture of galactooligosaccharides (GOS) and fructooligosaccharides (FOS) enhances Ca and P absorption (Abs), being a suitable tool to optimize its bioavailability and consequently bone health. The present study evaluated the effect of ...

: Osteonecrosis of the jaws (ONJ) is a relatively new adverse effect associated with bisphosphonate therapy, but no causal association has been established. By definition, a patient is considered to suffer from ONJ if he has current or previous treatment with a bisphosphonate, exposed bone in the maxillofacial region that has persisted for more than 8 weeks and no history of radiation therapy to the jaws. It has been proposed that ONJ could be linked with impaired topical immu...

Success in periodontal regeneration through guided tissue regeneration relies on the healing capacity of the host tissue. Platelet preparations are mitogenic and stimulate regeneration through high growth factor levels. Here we assessed collagen barrier membranes (CBM) as carriers for the secretome of activated platelets. We evaluated cell-attachment, the release of the secretome, and cell proliferation.Secretome of washed platelets (washed PSEC) and unw...

Skeletogenesis is an intricate process controlled by numerous transcriptional factors, hormones and signalling pathways. Recently, microRNAs emerged as important players in skeletogenesis but, only few were identified and most of their targets remain unknown. Previous works showed that miR-199a-2/214 cluster is essential for skeletal development and that miR-214 inhibits bone formation in mammals. However, data regarding its skeletal role in other vertebrates is scarce and its...

Background: An inadequate intake of nutrients, low levels of physical activity, and chronic diseases contribute to reduce muscle mass and physical performance in elderly. WHO reported that number of individuals aged ≥60 years will triple in 2050, with the sub-population aged >85 years that will grow faster than the others. Market of nutraceuticals and dietary supplements is growing in Italy, in particular aimed to improve health in elderly. Objective of this scoping ...

Introduction: Obstructive sleep apnea (OSA) is a common sleep-related respiratory disorder characterized by repeated episodes of apnea and hypopnea resulting in sleep fragmentation, nocturnal hypoxia and hypercapnia, and excessive daytime sleepiness. OSA has recently become a well-recognized problem in view of its high prevalence in the general population. OSA is associated with many endocrine disorders (hypogonadotropic hypogonadism, hypercortisolism, glucose intolerance). Th...

Low bone mass is a frequent complication of subjects with Rett syndrome. It is well known that many factors such as the use of anticonvulsant drugs, the presence of scoliosis, the nutrition status, the low levels of 25OHD and the ambulatory impairment influence the attainment of peak bone mass in Rett subjects. This study aimed to investigate the long-term influences of mobility on bone status in girls with Rett syndromeIn 47 girls with Rett syndrome, se...

We analyzed body composition (DXA, Hologic) in 334 young patients (aged 3–24 years) with chronic diseases, most of them on long-term glucocorticoid (GC) treatment, and monitored its changes over 3–14 years (6.9±6.2 years).Bone mineral content (BMC), fat mass (FM) and fat-free mass (FFM) were measured on total body (TB), trunk, upper limbs, lower limbs. BMC, FM, FFM were expressed as percentages and compared with age- and sex-matched health...

Objectives: Bone mass development in childhood and adolescence is crucial for peak bone mass (PBM) and low PBM may lead to osteoporosis later in life. The stability of bone mineral status through childhood and adolescence is known as tracking. The objective of this study is to determine the degree of tracking according to bone mass from pre-puberty into puberty in healthy Danish children.Methods: 190 healthy Danish children (97 boys) with mean age 9.25 y...