Bone Abstracts

Synthetic glucocorticoids such as dexamethasone (Dex) are widely used for treatment of premature infants with chronic lung disease or respiratory distress syndrome or in allergic conditions such as asthma. Adverse effect of these treatments is glucocorticoids-induced osteoporosis. On the other hand there are functional foods, for instance 2-oxoglutaric acid (2-Ox) a precursor of hydroxyproline the prevailing amino acid in bone collagen, which reduce the risk of osteoporosis. T...

Introduction: Low-magnitude, high-frequency (LMHF) mechanical stimuli lead to enhance bone formation and decrease resorption. This study aimed to investigate the effect of vibration on the bone loss induced by inflammatory cytokine, lipopolysaccharide (LPS).Methods and designs: Balb-C mice were administered to LPS (5 mg/kg) with two i.p. injections on days 0 and 4, while sham control group was injected with 400 μl of water for injection without LPS....

Bone remodeling is the key process in bone structural reorganization, and its alterations lead to changes in bone mechanical strength. Since osteons reflect different bone remodeling patterns, we hypothesize that the femoral cortex of females with miscellaneous age, disease, and treatment conditions will display distinct osteonal morphology and osteocyte lacunar numbers along with different mechanical properties.The specimens used in this study were coll...

Although trials have shown that exercise has positive effects on bone mineral density (BMD), not all exercise modalities are osteogenic and the majority of exercise trials have been conducted in older women. The aim of this study was to systematically review trials examining the effect of weight-bearing and resistance-based exercise modalities on the BMD of hip and lumbar spine of middle-aged and older men. Eight electronic databases were searched in August 2012. Only randomis...

Introduction: Osteoporosis and fragility fractures are recognized complications of rheumatoid arthritis (RA). Previously Riches et al. described a patient with celiac disease and severe osteoporosis in whom neutralizing antibodies to osteoprotegerin (OPG) were present. The aim of this study was to determine if OPG autoantibodies were present in patients with RA and other rheumatic diseases and to relate these to clinical features.Methods: We dev...

: In osteoporosis, poor adherence to bisphosphonate (BP) therapy is common, and is associated with poor outcomes and increased treatment costs (Siris 2006; Recker 2005). Although compliance is improved with monthly vs weekly dosing (Reginster 2008), no evidence suggests cycling through BP agents offers therapeutic benefit, assessed by bone mineral density (BMD). In two randomized, open-label studies in postmenopausal women aged ≥55 years previously treated with, but subo...

Children with osteogenesis imperfecta (OI) still suffer from frequent fractures, despite bisphosphonate treatment. Thus new therapeutic approaches are needed. Sclerostin is a protein that is thought to inhibit bone formation. Treatment with sclerostin antibodies (SclAB) increases bone mass in animal models and in clinical trials and may be a rational therapy for OI as well.Transgenic (TgOI) Col1a1Jrt/+ mice were gene...

The coupling of bone formation to bone resorption during treatment of postmenopausal osteoporosis with antiresorbers might be related to changes in Wnt/β-catenin signalling. We compared the effects of two bisphosphonate treatments on two Wnt inhibitors sclerostin (SOST) and Dickkopf-related protein 1 (DKK1). The study population included 72 women with postmenopausal osteoporosis participating simultaneously in two multicenter, placebo controlled trials. The patients were ...

Objectives: To investigate the burden and impact of gastrointestinal (GI) events in osteoporosis (OP) patients by i) examining the association of GI events with the likelihood of OP treatment initiation; ii) measuring the effect of GI events on treatment discontinuation; and iii) determining the impact of GI events post-OP treatment on health care resource utilization and cost. All subjects are identified utilizing national health registries which cover the whole Danish popula...

Many pharmacological treatments have been developed in order to prevent or treat postmenopausal osteoporosis. There is not any study in the literature comparing long-term treatments of osteoporosis. The aim of this work was to studythe effects of long-term prevention treatment with zoledronic acid (ZA) and strontium ranelate (SrR) on bone microstructure in ovariectomized rats.Sixty 6-month-old female Wistar rats were used in this study and divided into f...