Bone Abstracts

Pseudovitamin D-deficiency rickets (PDDR) is a rare autosomal recessive disorder resulting from a defect in renal 25-hydroxyvitamin D 1α-hydroxylase, which is encoded by the CYP27B1 gene. To our best knowledge, 48 mutations of the CYP27B1 gene have been identified so far. In the present study, we investigated CYP27B1 mutations in seven individuals from six separate families and identified nine different mutations: two novel missense mutations (G194R, R259L), three novel a...

Backround: Vitamin D dependent rickets type 1 (VDDR-1) is an autosomal recessive disorder caused by 1a hydroxylase enzyme deficiency, that leads to low or undetectable levels of 1,25 dihydroxyvitamin D despite normal levels of 25-hydroxyvitamin D levels. Additional laboratory findings include hypocalcemia and increased levels of parathyroid hormone. Clinically, it presents as early onset rickets and severe hypotonia.Presenting problem: A 6-year-old Cauca...

Objectives: Children during the intensive treatment of cancer might be exposed to vitamin D deficiency and consequently leads to, among other things, bone deficits and low bone mass. The aim of this study was: i) to assess the serum concentration of 25-hydroxyvitamin D (25-OH-D) in children diagnosed with acute lymphoblastic leukemia (ALL) at two time points (time of diagnosis and just after induction treatment), ii) to evaluate the impact of used drugs on the changes of 25-OH...

Background: The traditional Inuit diet in Greenland consists mainly of fish and marine mammals. The marine diet is an important source for vitamin D in Greenland. Vitamin D has anti-inflammatory capacity but markers of inflammation were high in Inuit with a high intake of marine food items. Yet, the effect of vitamin D on inflammation in Inuit remains unsettled.Objectives: To investigate the association between vitamin D and markers of inflammation in a ...

Introduction: This study aims to assess 25-hydroxyvitamin D—25(OH)D—status in perimenopausal women to analyze its relationships with serum PTH levels and bone mineral density (BMD).Methods: A total of 102 individuals who visited to climacteric clinic in Sanggye paik hospital participated in the study. Serum 25(OH)D and intact parathyroid hormone (PTH) were measured. BMD was determined by dual x-ray absorptiometry (DXA) at lumbar spine, femoral ...

Objectives: This cross-sectional study was done in order to assess the prevalence and determinants of vitamin D deficiency in children taking in account the following parameters: children’s age, season, geographic region and ethnicity.Methods: A cross-sectional prospective study was conducted in Israeli children aged 0–18 from Meuhedet Health Services during the year of 2016 in primary care pediatric clinics throughout all different geographic ...

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Obesity is associated with greater risk of proximal humerus and ankle fracture, despite greater areal BMD (aBMD). We aimed to investigate whether greater risk of some fractures in obesity was due to skeletal or non-skeletal determinants. 100 individually-matched pairs of normal weight (NW) (18.5–24.9 kg/m2) and obese (OB) (BMI >30 kg/m2) individuals, aged 25–40 and 55–75 years underwent DXA to determine hip and lumbar spine aBMD, whole ...

Objectives: Anorexia nervosa (AN) is a life-threatening eating disorder often associated with reduced bone mass. The aim of the present study was to investigate vitamin D status and the association with BMI, fat mass and bone mineral density (BMD) during a novel intensive nutrition therapy in young AN women.Methods: Twenty-five female AN patients (20.1±2.3 years, BMI 15.5±0.9 kg/m2) admitted to a specialised inpatient eating disorder...

Background and objective: Recent studies have demonstrated that higher serum 25-hydroxyvitamin D (25(OH)D) had a favorable effect on bone health. Osteocalcin, however, according to its serum concentration showed different outcomes for bone and aortic calcification. The aim of this cross-sectional study was to compare the bone mineral density (BMD) and coronary artery calcification score (CACS) according to the serum concentration of 25-hydroxyvitamin D and osteocalcin.<p c...