Bone Abstracts

Background: Alzheimer’s dementia (AD) and osteoporosis (OP) are common and parallel ageing and frequently coexist in an ageing population. Low BMD appears related to increased risk of AD. Various clinical conditions have been shown to alter acetylcholine (Ach) signalling and affect bone. Ach receptor (AchR) subunits and Ach esterase (AchE) are expressed in bone. Presynaptic Botox inhibit Ach release and impair bone healing and decrease bone mineral content. Poliomyelitis ...

Polynesians have higher bone mineral density and lower rate of hip fracture compared to age-matched Caucasian in New Zealand, and anecdotal evidence suggests that bones of Polynesian patients heal much faster than those of Caucasians. We compared gene expression in osteoblasts cultured form bone samples taken from patients of Polynesian and Caucasian origin, in order to identify genes and pathways that contribute to the greater density and accelerated healing of Polynesian bon...

Introduction: Most studies to date have focus on the effect of exercise interventions on bone remodeling. Furthermore, inflammation has been associated with those critical for bone physiology and remodeling. However, investigations analyzing the relationship between objective physical activity and bone metabolism and inflammatory markers and the potential interactions with BMD and body composition in older men are limited, which is the aim of the present study.<p class="ab...

Introduction and aims: Deficiency of vitamin D has been reported in subjects with many types of musculoskeletal pain. The aim of the present study was to determine the association between serum 25-hydroxyvitamin D (25(OH)D) and nonspecific skeletal pain in healthy Saudi women.Methods: Serum 25(OH)D were measured for 223 healthy women with nonspecific skeletal pain at different regions of the skeletal system including back pain. Serum 25(OH)D was measured...

Objective: To compare whether interval BMD changes in adolescent females that can be detected using conventional dual energy X-ray absorptiometry (DXA) can also be detected using quantitative peripheral quantitative computerized tomography scans (pQCT) and quantitative ultrasound (QUS)of the os calcis.Methods: Two groups of adolescent females were recruited for assessment of BMD changes over an interval of 22–24 months. These included full time coll...

Introduction: Duchenne muscular dystrophy (DMD) is caused by mutation in the dystrophin gene on the X-chromosome, leading to progressive deterioration in muscle function from early childhood. Corticosteroid treatment prolongs the time to loss of walking ability and improves life span. The combination of muscular weakness, reduced mobility and steroids increases the risk of secondary osteoporosis.Subjects and methods: In this prospective observational stu...

Despite mutations in SQSTM1 gene have been detected in up to 50% of patients with familial Paget’s disease of bone (PDB), their prevalence is low in sporadic PDB, likely due to the presence of additional predisposition genes. Recently, at least seven genes were associated with PDB in genome-wide-association studies, including polymorphic variation in OPTN,encoding for optineurin. In particular, a single OPTN variant (rs1561570) was highly associated with...

Muscle size and function are closely correlated with skeletal development. Examining the relationship between muscle and bone is thus of central interest in clinical bone research. Surprisingly, however, there is little information on how to evaluate the functional muscle-bone relationship in clinical studies. Many past studies on muscle–bone interaction seem to have analyzed muscle and bone measures that were convenient to collect but did not evaluate a specific model of...

Objectives: Adolescents with motor difficulties may have a higher fracture risk due to limited participation in high impact physical activities that improve bone mineral density (BMD). Equipment constrained resistance training (RT) interventions may be an effective way to improve both muscle strength and BMD in this population. The aims of this study were to investigate the effect of a GYM-based RT intervention on peripheral BMD, and to determine the extent of the relationship...

Objective: Insuficient vitamin D supply defined as serum hydroxyvitamin D (25OHD) <20 ng/ml is considered as one of possibile cardiovascular risk factors among adults with hypertension. Furthermore, some data also suggest an independent association between vitamin D deficits and hypertension and obesity during growth. The aim of the study was to assess vitamin D status in children and adolescents with hypertension.Methods: The cross sectional study w...