Bone Abstracts

Objectives: AIS is associated with both low bone mass and elevated serum bone alkaline phosphatase. The greater the latitude of the geographical region, the higher is the prevalence of AIS. These specific features were compatible with the presence of either Vit-D insufficiency or abnormal physiology with Vit-D. It is important to evaluate these potentially treatable conditions regarding their roles in the etiopathogenesis of AIS. The objectives of this case-control study were ...

Introduction: Adolescent idiopathic scoliosis (AIS) is associated with osteopenia, which was found to be a significant prognostic factor for curve progression. However, in-depth quantitative assessment of bone quality was previously hampered by invasive nature of the investigations. The recently available high-resolution pQCT (HR-pQCT) allows a three-dimensional assessment of the bone quality in-vivo. This study aimed to evaluate and compare the bone quality in AIS gi...

Mesenchymal cells alter and retain their phenotype during skeletal development through activation or suppression of signaling pathways. For example, we have shown that Wnt3a only stimulates osteoblast differentiation in cells with intrinsic osteogenic potential (e.g., MC3T3-E1 pre-osteoblasts) and not in fat cell precursors or fibroblasts (respectively, 3T3-L1 pre-adipocytes or NIH3T3 fibroblasts). Wnt3a promotes osteogenesis in part by stimulating autocrine production of the ...

Background: Hypoxia induces mesenchymal stem cells (MSCs) proliferation but results in a population with impaired osteogenic differentiation potential. Bone healing of tibial lengthening is enhanced by hyperbaric oxygen therapy. However, little is known about the effects of HBO on the Wnt signaling pathway in MSCs.Materials and methods: MSCs were cultured in complete medium and the osteogenic groups were cultured in osteogenic induction medium. Control c...

Adolescent idiopathic scoliosis (AIS) is associated with low bone mineral density (BMD) which has been reported to be an important prognostic factor for curve progression. In addition to BMD, high-resolution peripheral quantitative computed tomography (HR-pQCT) allows measurement of volumetric BMD, bone morphology, trabecular micro-architecture, and evaluation with structure model index (SMI) and finite element analysis (FEA) for mechanical property assessment. The aim of this...

Objectives: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional structural deformity of the spine and its etiology remains unknown. Girls with AIS have taller stature, longer arm span, lower BMI, and generalized osteopenia. Leptin has been postulated as one of the etiologic factors of AIS because of its important physiological functions in neuro-osseous development affecting skeletal growth, bone metabolism, energy expenditure and body composition. Previous st...

Analysis of genome wide data such as transcriptomics can identify genes of potential interest to bone biology. These techniques are primarily hypothesis-generating. Determining the role of candidate factors in bone ultimately requires in vivo experiments. Gene expression analysis of mouse osteoclast differentiation identified G protein-coupled receptor 137B (GPR137b) as highly upregulated. GPR137b is an orphan seven-pass transmembrane receptor of unknown func...

Study design: Prospective study.Objectives: The risk factors correlated with actual falls were assessed in patients with lumbar spinal stenosis.Materials and methods: In 201 patients (M:F 65:136) with symptomatic lumbar spinal stenosis, falls history within recent one year was investigated. The factors which were expected correlation with actual falls were evaluated together. Blood chemistry was performed to evaluate serum Vitamin ...

Introduction: The significance of sarcopenia and low muscle mass are especially emphasized in these days. Sarcopenia is well known to highly correlate with fragility and increases the risk of falling in the elderly and an important risk factor for disability and mortality. Evidence of inter-relaionship of muscle with bone metabolism is increasing. Therefore we investigated the relationship between BMD and muscle mass among healthy Korean premenopausal women.<p class="abste...

Type 2 diabetes is associated with fracture risk but, paradoxically, greater bone mineral density. The trabecular bone score (TBS) has been proposed as an index of bone microarchitecture associated with bone quality. This study compared the performance of TBS, bone mineral density (BMD), original and TBS adjusted FRAX scores in the prediction of vertebral fractures (VFs) in diabetic patients. This cross-sectional study enrolled 169 Korean postmenopausal diabetic women. Lateral...