Bone Abstracts

Aim: The aim of the research is to define the bone mineral density in patients, with Parkinson’s disease.Methods: We examined 12 women with Parkinson’s disease and 12 healthy women of appropriate age (average age: −63.6±6.25 vs 62.2±6.83 years, P=0.5). The duration of Parkinson’s disease was at list 5 years. All patients reseived levodopa.Results: BMD of women with Parkinson’s disease wa...

While a strong emphasis has been put on the characteristics of trabecular bone due to its’ high metabolic rate, the human skeleton actually consists of approximately 80% cortical bone. Furthermore, the cortical bone supports a major proportion of the mechanical load (i.e., up to 96%) at common fracture sites, such as the base of the femoral neck and the intertrochanteric region. In these regions of the hip, large compressive stresses concentrate during walking as well as ...

Pathologist Christian Georg Schmorl described a specific type of vertebral lesion, which is now known as Schmorl’s node. A Schmorl’s node or intradiscal herniation is herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of an adjacent vertebra. Schmorl nodes are seen primarily in the thoracolumbar spines in an elderly population. Schmorl nodes are associated with moderate but not advanced degenerative changes. An 11-year-male pres...

Objective: To examine the efficacy and safety of direct administration of zoledronate acid (ZOL) on local osteoporotic lesion of ovariectomized rats.Methods: Six weeks later after ovariectomy, 16 6-month-old female S.D. rats were divided into the two groups with no differences of body weight and BMD of the proximal tibia. In the group L, 50 μl ZOL at a dose of 67 μg/kg were locally injected into the bone marrow between the two dr...

The childhood obesity is a global epidemic. Some studies with pre-pubertal children reported a positive relationship between fat mass and bone. However, there are no available data on the influence of the nutritional status on parameters of quantitative ultrasound (QUS). The aim of this study was to evaluate the influence of nutritional status in bone mass assessed by QUS of proximal phalanges in girls. The bone mass parameter, amplitude dependent speed sound (AD-SoS) in meter...

BAG-1 interacts with diverse proteins including heat shock proteins (HSC70/ HSP70) and nuclear hormone receptors to modulate cell proliferation, differentiation and apoptosis. We have shown that bone marrow stromal cells (BMSCs) of Bag-1+/− female mice display reduced BMP-2-directed osteogenic differentiation potential. Estradiol binds to estrogen receptors (ERs) and is functionally involved in BMP-directed osteogenic differentiation of osteoprogenito...

In order to examine metabolic and biophysical parameters arising from obesity, male rats were given to drinking 30% sucrose (p/v) for 8 weeks. During the experimental period, animals in the control group (C) consumed higher amounts of food and water, but the body mass was smaller than the group receiving sucrose (S). In this group, the caloric load given to the animals for eight weeks resulted in increased energy consumption, in glycemia and in plasma leptin and abdominal fat....

Low levels of 25-hydroxyvitamin D have been documented among inhabitants of the wider Middle East and North African countries. Sunlight has long been recognized as a major provider of vitamin D. In this study we aimed to determine the optimum time for sun exposure in the Central region of Riyadh, Saudi Arabia. Ampoules containing 7-dehydrocholesterol in ethanol were exposed to sunlight every hour starting from sunrise until sunset in July and December. Our results demonstrated...

Heritability of bone mineral density (BMD) varies at skeletal sites, possibly reflecting different relative contributions of environmental and genetic influences. To quantify shared genetic influences across different sites, we estimated the genetic correlation of BMD at the upper limb (UL), lower limb (LL), and skull (S) obtained from whole body DXA scans, using bivariate genome-wide complex trait analysis (GCTA). The study (n=9395) combined data from the Avon Longit...

Heritability of bone mineral density (BMD) varies at skeletal sites, possibly reflecting different relative contributions of environmental and genetic influences. To quantify shared genetic influences across different sites, we estimated the genetic correlation of BMD at the upper limb (UL), lower limb (LL) and skull (S) obtained from whole body DXA scans, using bivariate genome-wide complex trait analysis (GCTA). The study (n=9395) combined data from the Avon Longitu...