Bone Abstracts

see PP398....

Introduction: Osteoporotic fractures are known to be costly to society but estimates tend to be based on small scale prospective studies. In the following we report national data for healthcare costs due to fractures in patients with osteoporosis.Study population and methods: All Danish residents aged 35+, mean age 70.5 years, 13% men, 27.3% prior major osteoporotic fracture, who began bisphosphonates for osteoporosis between 1/1997 and 12/2002 (n</e...

Purpose: The aim of this study is to determine the chemical information in trabecular bone by Raman spectroscopy in the human distal femur at the microstructural level.Methods: The subchondral trabeculae were obtained from the middle of medial articular surface of the distal femurs in the two cadavers (one is with and the other is without OA). Raman spectroscopy, a non-destructive technique, was employed to determine the chemical information of the trabe...

Objectives: Vertebral fracture (VF) is a hallmark of osteoporosis, and it increases morbidity, mortality and large amount of medical cost. In this study, we aimed to describe the treatment pattern and estimate the cost of VF among elderly patients in Korea.Methods: Using Korean national healthcare claims database, we analyzed a 2% sample of patients aged &gE; 50 years between years of 2008 and 2012. New VF was identified on the basis of selected ICD-10 c...

Recent genetic studies in rodents have revealed that circulating serotonin plays a key role in regulating bone formation and skeletal mass. However, the reported effects of circulating serotonin on bone mass in humans have been conflicting. We determined whether circulating serotonin levels influenced the rate of bone loss and fractures in males.We assessed the effect of serum serotonin on bone loss rate in a population-based cohort of 202 ambulatory mal...

Children with cystinosis have numerous risk factors for impaired bone accrual. We used state-of-the-art quantitative imaging of bone microarchitecture (HR-pQCT) to measure trabecular and cortical microstructure and bone strength in children and adolescents (5-20yrs) with cystinosis. We enrolled 20 cystinosis patients and recruited 34 healthy age- and gender- matched controls. Distal radius and tibia HR-pQCT scans (XtremeCT II, Scanco Medical) were acquired 2...

Background and objectives: Vitamin D deficiency causes calcium-depleted bone, which further weakens the bones and increases the risk of fractures. Also, It is known as related to obstetrics problem like gestational diabetes, infections, preeclampsia and incidence of caesarean section as well as glucose metabolism, immune system, cardiovascular diseases and cancer.Recently, the relationship between preterm birth and vitamin D deficiency becomes the main i...

The pediatric osteogenesis imperfecta (OI) team at our university hospital was established in 1991. The multi- and inter-disciplinary team consists of: pediatric neurologist, nurse, nursing assistant, physiotherapist, occupational therapist, orthopedic surgeon, orthotist, radiologist, dentist and geneticist. We also have a close collaboration with other specialists.Our assignment is high qualified diagnostics, functional assessments and also individualiz...

A osteoporotic fracture has become a global health issue that causes tremendous impact on mortality as well as heavy socioeconomic burden. Previous studies suggested that vitamin D may prevent fractures by improving muscle mass as well as via increasing bone density directly. The purpose of the study is to determine that the influence of vitamin D on bone mineral density depends on its effects on muscle mass.We analyzed the data from Korean National Heal...

Osteoporotic patients have poor bone quality and high risk of dental and orthopaedic implant failure. Lithium chloride (LICl) has been reported to enhance osteogenesis. However, the role of LiCl in bone formation and implant osseointegration in osteoporotic condition is still unknown. Therefore, we aimed to investigate the effect of LiCl on bone formation and implant osseointegration in osteoporotic rats.Three months old Sprague–Dawley female rats (...