Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0005p84 | Bone Matrix | ECTS2016

Anabolic parathyroid hormone (PTH) treatment does not alter periosteal bone mineral composition during primary and secondary mineralisation

Vrahnas Christina , Pearson Thomas A , Brunt Athena R , Forwood Mark R , Bambery Keith R , Tobin Mark J , John Martin T , Sims Natalie A

Parathyroid hormone (PTH) is used to stimulate bone formation in osteoporotic patients, however concerns have been raised about the quality of the matrix produced since lower levels of total matrix mineral have been reported in osteoporotic and fracture patients treated with PTH. High resolution synchrotron-based Fourier Transform Infrared Microscopy (sFTIRM) was used to determine mineral content in age-matched bone during anabolic PTH treatment, using the simplified lamellar ...
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ba0005p143 | Cell biology: osteoblasts and bone formation | ECTS2016

RUNX2, osterix and the human sclerostin gene: searching molecular and epidemiological interactions

Perez-Campo Flor , Santurtun Ana , Garcia-Ibarbia Carmen , Pascual Maria A , Valero Carmen , Garces Carlos , Sanudo Carolina , Zarrabeitia Maria T , Riancho Jose A

Sclerostin, encoded by the SOST gene, functions as an inhibitor of the Wnt pathway and thus it is an important regulator of bone homeostasis. The fact that osteoblasts, the only cells expressing SOST, lay buried deeply in the bone matrix, poses intrinsic difficulties to the study of the regulation of this gene. Since RUNX2 and SP7/OSX are two known regulators of the differentiation of cells of the osteoblastic lineage, the aim of this study was to determine t...
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ba0006oc20 | (1) | ICCBH2017

Autoimmune hyperphosphatemic tumoral calcinosis

Ramnitz Mary Scott , Burbelo Peter , Egli-Spichtig Daniela , Perwad Farzana , Romero Christopher , Ichikawa Shoji , Farrow Emily , Econs Michael , Guthrie Lori , Gafni Rachel I. , Collins Michael T.

Background: Hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is an autosomal recessive disorder due to deficiency of or resistance to intact fibroblast growth factor 23 (FGF23). This leads to hyperphosphatemia, increased renal reabsorption of phosphorus (TRP), and elevated or inappropriately normal 1,25-dihydroxyvitamin D (1,25D). Affected individuals may develop ectopic calcifications and/or diaphyseal hyperostosis. Mutations ...
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ba0002lb2 | (1) | ICCBH2013

WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta identify a key WNT ligand regulating bone mass

Laine Christine , Joeng Kyu Sang , Campeau Philippe , Kiviranta Riku , Tarkkonen Kati , Grover Monica , Lu James , Pekkinen Minna , Wessman Maija , Heino Terhi , Nieminen-Pihala Vappu , Laine Tero , Kroger Heikki , Cole William , Lehesjoki Anna-Elina , Krakow Deborah , Curry Cynthia , Cohn Daniel , Gibbs Richard , Lee Brendan , Makitie Outi

The role of the WNT pathway in skeletal maintenance has been extensively studied since the identification of mutations in key signaling WNT mediators (LRP5 and sclerostin) in high and low bone mass phenotypes. However, the identity of the key WNT ligand that signals via LRP5/6 has remained unknown. We aimed to identify genes with a major effect on the skeleton by studying individuals and families with early-onset osteoporosis or osteogenesis imperfecta (OI).<p class="abste...
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ba0005op35 | Pre-Clinical (1) | ECTS2016

Identification and functional validation of microRNA expression in human bone tissue

Ostanek Barbara , Bedrac Simona Mencej , Kern Barbara , Vrtacnik Peter , Mlakar Vid , Bego Tamer , Komadina Radko , Trebše Rihard , Marc Janja

see P248....
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ba0005p248 | Genetics and Epigenetics | ECTS2016

Identification and functional validation of microRNA expression in human bone tissue

Ostanek Barbara , Bedrac Simona Mencej , Kern Barbara , Vrtacnik Peter , Mlakar Vid , Bego Tamer , Komadina Radko , Trebše Rihard , Marc Janja

miRNAs are epigenetic regulators of gene expression, increasingly recognised as prominent regulators of bone metabolism. Following our in vitro studies of miRNAs profiles in osteoblasts we extended the research to human bone samples. Our aim was to find and functionally validate miRNAs differentially expressed in osteoporotic and osteoarthrotic bone with potential for targeting genes relevant in bone metabolism.Trabecular bone tissue samples wer...
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ba0004op12 | (1) | ICCBH2015

A non-invasive method for screening vitamin D insufficiency for adolescents using skin colourimetry

Lam Tsz Ping , Lee Wayne Y W , Cheung Franco T F , Tsang Echo K L , Wong Lyn L N , Lee Simon K M , Ng Bobby K W , Cheng Jack C Y

Introduction: Effective screening for vitamin D (Vit-D) insufficiency is desirable. Pigmentation of unexposed (constitutive) skin and exposed (facultative) skin can be measured with skin colourimetry to assess dermal capability in synthesizing Vit-D and degree of sunlight exposure respectively. This study aimed at evaluating whether skin colourimetry could be used to screen Vit-D insufficiency among adolescents.Methods: 240 healthy adolescents (mean age=...
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ba0001pp338 | Osteoporosis: evaluation and imaging | ECTS2013

Low testosterone levels are associated with poor peripheral bone mineral density and quantitative bone ultrasound at phalanges and calcaneus in healthy elderly men

Lavado-Garcia Jesus Maria , Rey-Sanchez Purificacion , Costa-Fernandez Carmen , Martinez Mariana , Leal Alejo , Rodriguez-Velasco Francisco Jose , Pedrera-Zamorano Juan Diego

Context: Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels.Aims: To examine the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men.Methods and material: We examined 162 me...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0001pp118 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Role of estrogen replacement therapy in the control of immune system in postmenopausal osteoporosis

D'Amelio Patrizia , Sassi Francesca , Buondonno Ilaria , Fornelli Giorgia , Bonardo Elena , Isaia Giovanni Carlo

Introduction: We have recently shown that T cells play a key role in postmenopausal bone loss, here we investigate the influence of estrogen replacement therapy in the control of the immune system and osteoclastogenesis.Description of methods: We enrolled in the study 30 women with postmenopausal osteoporosis randomized to estrogen replacement therapy (HRT) or raloxifene (RLX) associated with calcium and vitamin D or calcium and vitamin D alone.<p cl...
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Bone Abstracts
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