Bone Abstracts

Metabolic bone disease (MBD) of prematurity is a well-recognized complication of preterm birth. Yet there is limited evidence for the optimal assessment, monitoring, and subsequent bone health management.Retrospective audit of 171 infants born <32 weeks’ gestation between November 2012 and January 2014 at three Monash Health neonatal units (Melbourne, Australia) was undertaken. Infants had mean gestational age (GA) 28.6±2.1 weeks and birth ...

FGF-23 is a phosphate regulating hormone and its production may be stimulated by circulating levels of 1,25-dihydroxyvitamin D (1,25-(OH)2D). Teriparatide administration increases levels of 1,25-(OH)2D, however it is unclear whether this mediates changes in FGF-23 levels. The aims were i) to determine the effect of teriparatide treatment on circulating levels of FGF-23 and 1,25-(OH)2D and ii) to describe the time course of effect in postmenopau...

Delivery of recombinant human bone morphogenetic protein (rhBMP2) with various carriers has been showing the successful induction of bone formation in many bony defects, including oral and maxillofacial regions. However, effectiveness of the exogenous proteins, when repeatedly administered into different regions in an individual, has not been determined. The present study was aimed to examine alterations of ectopic or orthotopic bone generation and serum level of anti-BMP2 ant...

Infantile malignant osteopetrosis (IMO) is a rare, lethal, recessive disorder characterized by dysfunctional osteoclasts. TCIRG1, encoding the osteoclast V-ATPase, is mutated in 50% of IMO patients. We have previously shown that the resorptive function in osteoclasts derived from IMO patients can be restored in vitro by expressing TCIRG1 using a lentiviral vector. In this study, we aim to investigate the cellular response to vector-derived TCIRG1 expression and to det...

Introduction: Hypertrophy of ligamentum flavum (LF) induces narrowing of spinal canal which develops neurogenic claudication. Several mechanisms of LF hypertrophy have been suggested. Among them inflammatory cytokine play a crucial role in LF hypertrophy by increasing collagen synthesis. Cyclooxygenase-2 (COX-2) pathway shares inflammatory reaction from infection and arthritis. Selective COX-2 inhibitor (COX-2si) might modulates collagen synthesis via suppressing inflammatory ...

Background: Asian-specific prediction model for estimating the individual risk of osteoporotic fracture was rare. We aimed to develop a Korean fracture risk prediction model using clinical risk factors and assess external validity of the final model.Methods: A total of 718,306 Korean men and women aged 50–90 were followed for 7 years in national system based cohort study. Fifty percent were randomly assigned to the development dataset and 50% to the...

Introduction: Acute vertebral compression fractures cause severe back pain and need long time to heal. The progression of fracture or nonunion is not rare. The teriparatide is a synthetic parathyroid hormone which has been used as anabolic agent and treatment of osteoporosis. It can also be used for promoting fracture healing in special condition. Periodic infusion of teriparatide enhances bone formation and increases bone strength. We evaluated the effect of periodic teripara...

Background: In 2004, we reported a 48.1% prevalence of osteoporosis in an Ibansung cohort. The current prospective intervention study was undertaken in order to estimate the prevalence of osteoporosis from 2004 to 2015 and the increasing treatment rate of osteoporosis following osteoporosis screening tests with ultrasound bone densitometry and education in the same cohort.Methods: From November 1, 2014 to August 31, 2015, 960 adults ≥50 years of ag...

Osteogenesis imperfecta (OI) is a systemic connective tissue caused by mutations in collagen type 1 related genes. Patients with OI suffer from multiple fractures and various degrees of growth deficiency and bone deformity. Other symptoms are early hearing loss, abnormal dental tissue and hypermobility. It is not known whether the systemic effect of a defect collagen type 1 influences the quality of life in people with OI. We aimed to investigate health related quality of life...

Objectives: Fibrous dysplasia is a rare bone and endocrine disorder resulting from somatic activating mutations in GNAS. In the skeleton, proliferation of undifferentiated stromal cells results in osseous lesions that are prone to deformity, fracture, and pain. Lesions may affect one bone or many, and may occur in isolation or in association with hyperfunctioning endocrinopathies, termed McCune-Albright syndrome (MAS). Scoliosis is a potentially serious, even lethal c...