Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0005cabs.oc3.4 | Oral Communications | ECTS2016

Anti-sclerostin treatment prevents multiple myeloma bone disease and reduces tumour burden

McDonald Michelle , Reagan Michaela , Terry Rachael , Pettitt Jessica , Le Lawrence , Mohanty Sindhu , Kramer Ina , Kneissel Michaela , Brooks Daniel , Cheng Tegan , Little David , Bouxsein Mary , Rosen Cliff , Ghobrial Irene , Croucher Peter

Multiple myeloma is characterized by extensive bone marrow tumour and destructive osteolytic lesions. Both increased bone resorption and suppressed bone formation result in lesions and pathological fractures. Anti-resorptive therapies prevent further bone loss but patients continue to fracture, arguing for new therapies which increase bone strength. Anti-Sclerostin (Anti-Scl) is a potent stimulator of bone formation, is currently in clinical trials for osteoporosis, however it...
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ba0005oc1.1 | Clinical trials and osteoporosis treatment | ECTS2016

Efficacy of odanacatib in postmenopausal women with osteoporosis: subgroup analyses of data from the phase 3 long-term odanacatib fracture trial (LOFT)

Saag Kenneth G , Alexandersen Peter , Benhamou Claude-Laurent , Gilchrist Nigel , Halse Johan , Michael Lewiecki E. , Lippuner Kurt , McClung Michael , Shiraki Masataka , DaSilva Carolyn A , Verbruggen Nadia , Scott Boyd B , Lombardi Antonio

Odanacatib (ODN), a selective oral inhibitor of cathepsin K, is in development for the treatment of osteoporosis. In the primary efficacy analysis of the Phase 3, Long-Term ODN Fracture Trial (LOFT; NCT00529373), ODN significantly reduced fracture risk compared with placebo in postmenopausal women with osteoporosis. Pre-specified subgroup analyses evaluated the efficacy of ODN in patient subgroups.Women aged ≥65 years, without baseline radiographic...
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ba0005p8 | Arthritis and other joint diseases: translational and clinical | ECTS2016

A clinical study to examine thresholds of joint space width and joint space area for identification of knee osteoarthritis

Ljuhar Richard , Norman Benjamin , Ljuhar Davul , Haftner Tobias , Hladuvka Jiri , Mai Mary Bui Thi , Canhao Helena , Rodrigues Ana Maria , Gouveia Nelia , Branco Jaime , Nehrer Stefan , Fahrleitner-Pammer Astrid , Dimai Hans-Peter

Objective: Osteoarthritis (OA) is a degenerative, slowly developing joint disease. Although clinical indications of OA can vary among different definitions there is a general agreement that the disease is associated with cartilage narrowing. However, there is no general consensus about the threshold below which the joint space width (JSW)/joint space area (JSA) can be certain indicators for the state of OA. Therefore this study evaluates these limits to reveal quantitative inf...
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ba0005p302 | Osteoporosis: evaluation and imaging | ECTS2016

A novel feature selection algorithm based on bone micro architecture analysis to identify osteoarthritis

Ljuhar Richard , Norman Benjamin , Ljuhar Davul , Haftner Tobias , Hladuvka Jiri , Bui Thi Mai Mary , Canhao Helena , MariaRodrigues Ana , Gouveia Nelia , Branco Jaime , Nehrer Stefan , Fahrleitner-Pammer Astrid , Dimai Hans-Peter

Objective: Texture information of the subchondral bone area (SBA) of 2D radiographs represents a promising possibility for evaluating the state of osteoarthritis (OA). However such features are likely to vary within the SBA and therefore the selection of the region of interest (ROI) plays a crucial role. Thus, a feature selection algorithm (FSA) is being applied in order to determine ROIs that enable an optimum discrimination between patients with and without OA.<p class="...
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ba0007p51 | (1) | ICCBH2019

Higher dose of burosumab is needed for treatment of children with severe forms of X-linked hypophosphatemia

Zhukouskaya Volha V , Audrain Christelle , Lambert Anne-Sophie , Colao Annamaria , Kamenicky Peter , Adamsbaum Catherine , Nevoux Jerome , Chaussain Catherine , Wicart Philippe , Briot Karine , Di Rocco Federico , Trabado Severine , Prie Dominique , Rothenbuhler Anya , Linglart Agnes

Background and aim: Burosumab is a monoclonal antibody against anti-FGF23, which has been recently approved for treatment of X-linked hypophosphatemia (XLH). Beyond clinical trials, little is known about its efficacy/safety in clinical practice which is the aim of study.Patients/Methods: 39 children with XLH were switched from conventional therapy to burosumab (starting dose 0.4 mg/kg), because of following indications: non-responder to conventional ther...
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ba0003pp309 | Osteoporosis: treatment | ECTS2014

Treatment of severe vertebral osteoporosis with teriparatide or 1--84-PTH: results from a Danish Database Initiative

Hyldstrup Lars , Langdahl Bente L , Eiken Pia , Hermann Pernille , Schwarz Peter , Moeller Marianne Kleis , Bennedbaek Finn , Madsen Ole Rintek , Abrahamsen Bo , Stilgren Lis , Smitz Anita , Pelch Randi , Brockstedt Helle , Jarlov Anne , Morch Marianne , Sorensen Henrik Ancher , Mortensen Lene , Andreasen Per Nygaard , Hoeck Hans Christian , Jensen Jens-Erik Beck

A Danish database initiative was established in 2003 with the purpose of evaluating patients treated with teriparatide. After the introduction in 2006 of 1–84-PTH, these patients were also included. A total of 1494 patients from 19 centers were reported to the database, until closure in 2011. The reported patients correspond to a third of all patients in Denmark receiving anabolic treatment during this time period. With regard to age and sex the reported patients do not d...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0001pp178 | Cell biology: osteoblasts and bone formation | ECTS2013

Regulation and function of immunosuppressive molecule human leukocyte antigen G5 in human bone tissue

Deschaseaux Frederic , Gaillard Julien , Langonne Alain , Chauveau Christophe , Naji Abderrahim , Bouacida Amina , Rosset Philippe , Heymann Dominique , de Pinieux Gonzague , Rouas-Freiss Nathalie , Sensebe Luc

Bone-marrow mesenchymal stem cells (MSCs) are the origin of bone-forming cells with immunomodulation potential. Among the generated immunosuppressive molecules there is HLA-G5. HLA-G proteins play a crucial role in promoting the acceptance of allografts. However, the mechanisms regulating the expression of HLA-G5 in human MSCs are unknown. We induced differentiation of human MSCs (harvested from iliac crests of healthy volunteers after their informed consent following approved...
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ba0005p133 | Cancer and bone: basic, translational and clinical | ECTS2016

Novel evidence that ApoA-1 deficiency facilitates HSC mobilization and differentiation and halts HSC quiescence and self-renewal in mice

Mastora Ioulia , Papachristou Nicholaos , Blair Harry , Kalyvioti Elena , Syggelos Spyros , Karavia Eleni , Kypreos Kyriakos , Papachristou Dionysios

Recent evidence suggests that osteoblastic bone marrow niche is vital for the maintenance and self-renewal of hematopoietic stem cells (HSC). It has been recently proposed that cholesterol efflux pathways participate in HSC mobilization and that cholesterol-sensing pathways control the proliferation of HSC progenitors. Moreover, we have recently documented that HDL perturbations result in impaired osteoblastic function in mice. In the present study, we aimed at investigating t...
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ba0005p191 | Cell biology: osteoclasts and bone resorption | ECTS2016

Homer proteins modulate RANKL-induced NFATc1 signaling in osteoclast differentiation and bone metabolism

Yang Yu-Mi , Son Aran , Kang Jung Yun , Shin Dong Min

Ca2+ signaling and NFATc1 activation are essential for RANKL-induced osteoclast differentiation through the induction of Ca2+ oscillation, calcineurin activation, and translocation of NFATc1 into the nucleus. Homer proteins are scaffold proteins that have been proposed to modulate multiple Ca2+ signaling proteins, including inositol 1,4,5-triphosphate receptors, ryanodine receptors, transient receptor potential channels. In this study, we inves...
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Bone Abstracts
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