Bone Abstracts

Prof. David Little received his Medical Degree from the University of Sydney where he is Conjoint Professor of Paediatrics and Child Health, specialising in Orthopaedic Surgery. Prof. D Little is Head of Orthopaedic Research and Biotechnology at The Children’s Hospital at Westmead, part of the Sydney Children’s Hospital Network. He has broad clinical interests in Children’s Orthopaedi...

Biographical DetailsSandy Burnham received his MD from the Perelman School of Medicine at the University of Pennsylvania (UPENN) in 1997 and completed his Pediatrics Residency in 2000 and General Pediatrics and Pediatric Rheumatology Fellowships in 2004 at The Children’s Hospital of Philadelphia (CHOP). He received his Master of Science in Clinical Epidemiology from UPENN in 2006. Dr...

Paget’s disease of bone is a condition where the process of bone remodeling is disrupted; Its primary event is an increased bone resorption followed by a subsequent reactive bone formation. The disease is most common in central Europe, the United Kingdom, Australia, and New Zealand. It is also found, though with lower incidence, in southern Europe, Scandinavia, and the United States. It is extremely rare in East Asian countries, especially in Korea, Japan, China, the Midd...

Associate Professor Munns is a Senior Staff Specialist in Bone and Mineral Medicine and Endocrinology at the Children’s Hospital at Westmead and Conjoint Associate Professor in the Sydney Medical School at the University of Sydney, Australia. Following the completion of his Paediatric and Endocrinology training at The Royal Children’s Hospital, Brisbane, Australia, Associate Professor Munns was Clinical Associate in Genetic and Metabolic Bone Disor...

Biographical DetailsFrank Rauch trained as a pediatrician at the Children’s Hospital of Cologne University, Germany, where he started working on pediatric bone disorders in Dr Schoenau’s laboratory. He then performed a research fellowship on metabolic bone disorders at the Shriners Hospital for Children, Montreal, Canada. Since 2001 he has been a clinician scientist at the Shrin...

Biographical DetailsDr. Outi Mäkitie received her MD and PhD from the University of Helsinki, Finland where she also completed training in Pediatrics and in Pediatric Endocrinology. After a 3-year post-doctoral clinical and research fellowship at The Hospital for Sick Children in Toronto, Canada, she returned to Finland and served as Head of the Metabolic Bone Clinic, Children’s...

Biographical DetailsKen White, PhD is the David D Weaver Professor of Genetics in the Department of Medical and Molecular Genetics at the Indiana University School of Medicine in Indianapolis, IN, USA. He serves as Director of the Division of Molecular Genetics and Gene Therapy. Dr K White’s research interests focus on the molecular genetics of metabolic bone diseases in regards to p...

Biographical DetailsAssociate Professor Craig Munns is a Senior Staff Specialist in Bone and Mineral Medicine and Endocrinology at the Children’s Hospital at Westmead and Conjoint Associate Professor in the Sydney Medical School at the University of Sydney, Australia. Following the completion of his Paediatric and Endocrinology training at The Royal Children’s Hospital, Brisbane...

While a strong emphasis has been put on the characteristics of trabecular bone due to its’ high metabolic rate, the human skeleton actually consists of ~80% cortical bone. Furthermore, the cortical bone supports a major proportion of the mechanical load (i.e. upto 96%) at common fracture sites, such as the base of the femoral neck and the intertrochanteric region. In these regions of the hip, large compressive stresses concentrate during walking as well as during falls an...

Gaucher’s disease is a glycolipid storage disorder caused by an autosomally inherited deficiency of the lysosomal enzyme glucocerebrosidase. The majority of patients with Gaucher’s disease develop abnormal bone remodelling with severe consequences, including osteonecrosis, bone crises, and osteoporosis related fractures. Although enzyme replacement therapy is effective at reversing many of the pathological consequences, and preventing further progression of this dise...