Bone Abstracts

The purpose of this study is to understand the changes of TBS scores in Asian females by comparing 1990’s and 2010’s DXA images.We have compared the DXA images of 3774 Korean females (age: 20–79) to Japanese (age: 20–79). While Korean DXA images were obtained in 2014 and 2015, Japanese data were obtained in 1996. Participants who have abnormal DXA images or lumbar disease were excluded. TBSiNsight® software (v. 2.1.1, ...

The purpose of this study is to assess the correlation of trabecular bone score (TBS) to variable factors, i.e. sex, age, body size and BMD. Moreover, we want to find variables of correlation coefficient change with aging.We randomly selected 2,906 subjects (1726 female and 1180 male, age range 20’s to 70’s) from several hospitals in Korea. Participants who have abnormal Dual Energy X-ray Absorptiometry (DXA) images or lumbar disease were exclu...

Background: In 2004, we reported a 48.1% prevalence of osteoporosis in an Ibansung cohort. The current prospective intervention study was undertaken in order to estimate the prevalence of osteoporosis from 2004 to 2015 and the increasing treatment rate of osteoporosis following osteoporosis screening tests with ultrasound bone densitometry and education in the same cohort.Methods: From November 1, 2014 to August 31, 2015, 960 adults ≥50 years of ag...

Objectives: While local gene therapy for bone applications has shown some success in preclinical models, systemic delivery of transgenes to the skeleton remains a considerable challenge. Viral vectors such as adeno-associated viruses (AAVs) have great potential as vectors for systemic transgene delivery and may be adapted for emerging gene editing technologies. Furthermore, AAV vectors can have high efficiency, low immunogenicity, and selective tropism towards different tissue...

Objectives: From late 2015 a new protocol for zoledronic acid was adopted in our centre. This led to many children changing from pamidronate (PAM) to zoledronic acid (ZA) treatment. In a minority of cases the children and/or their families felt strongly that they wanted to change back to PAM. We present the characteristics of that minority and how bone turnover markers (BTMs) and bone mineral densities (BMD) changed whilst on ZA.Method: From Nov 2016 to ...

Objective: The potential for clinical trials to impact patient care may be limited if the outcomes reported vary by trial and lack direct relevance to patients. We aimed to systematically assess the scope and consistency of outcomes reported in randomised trials of interventions for children with osteogenesis imperfecta.Methods: We systematically searched for all published and unpublished randomised trials of interventions for children with osteogenesis ...

Objectives: Adolescent Idiopathic Scoliosis (AIS) is associated with low bone mass. This study aimed at evaluating the therapeutic effect and its determinants of Ca+Vit-D supplementation in improving bone strength and preventing curve progression in AIS.Methods: This was a randomized double-blinded placebo-controlled trial recruiting AIS girls (11–14 years old, Tanner stage<IV) with femoral neck BMDZ-scores<0 and Cobb angle≥15°. 3...

BMPs and canonical Wnts are the representative developmental signals that enhance osteoblast differentiation and bone formation. Previously, we demonstrated that EGF inhibits BMP2-induced osteoblast differentiation through the induction of Smurf1 expression. However, the regulatory role of EGF in Wnt/β-catenin-induced osteoblast differentiation has not been elucidated. In this study, we investigated the effect of EGF on Wnt/β-catenin signaling-induced osteoblast diff...

Benign jaw tumors including ossifying fibroma (OF) can be often incidentally diagnosed due to their slow-growing and painless characteristics. In cases of massive growing jaw tumors, it can result in deformity of teeth, infection and intracranial complications. Depending on the location of tumor lesion, it may not completely resected and recur after the primary operation, which may require subsequent operations.Molecular mechanisms and the etiology of th...

C-C chemokine receptor 5 (CCR5) is a co-receptor of macrophage-tropic viruses including HIV. Epidemiological and pathological findings have reported that functional changes in CCR5 correlate with HIV transmission bone destruction disease. However, the roles of CCR5 in bone pathophysiology have not been well documented.Ccr5-deficient osteoclasts showed decreased bone resorption activity accompanied with disorganized cellular architecture and impa...