Bone Abstracts

Iisn’t uncommon to encounter patients with both a fragility fracture and only a slightly low BMD value or even normal one. Currently the DXA technology can assess information on trabecular microstructural texture supplementing the standard BMD measurement, using a new method: the trabecular bone score (TBS). In order to check TBS, BMD and their combination to discriminate patients with vertebral fracture, we scanned 946 subjects. The cohort was stratified using the WHO di...

Objective: Evidence for further reduction of nonvertebral fracture (NVFX) beyond 3 years of antiresorptive therapy is limited. Since long-term denosumab (DMAb) treatment is associated with continuous increases in BMD and sustained fracture reduction, we analyzed the influence of femoral neck (FN) BMD after 3 years on NVFX rates.Methods: Long-term subjects received 7 continuous years of DMAb; cross-over subjects received 3 years of placebo (FREEDOM) and 4...

Multiple factors of risk have been described to the osteoporosis (OSP) and fractures in people infected by human immunodeficiency virus (HIV). Antiretroviral treatment has changed the vital prognosis of these patients, nevertheless seems that antiretroviral treatments can cause a greater loss of bone mineral density (BMD). Experts support the use of densitometry screening for HIV-infected postmenopausal women and men older than 50 years.Objectives: To ev...

Low bone mineral density (BMD) is an important and modifiable risk factor for fracture in postmenopausal women with osteoporosis. Denosumab (DMAb) shows a stronger relationship between BMD increases and antifracture efficacy than oral bisphosphonate (BP) therapies. Subjects who remain at higher risk of fracture despite current BP therapy need treatment. In two studies, DMAb significantly increased BMD and decreased bone turnover markers vs a BP (ibandronate (IBN) or risedronat...

Objectives: Adolescents with Developmental Coordination Disorder (DCD) have significantly lower bone mineral density (BMD) compared to their non-affected peers. Their difficulty in performing weight bearing movement skills is hypothesised to explain poorer bone characteristics. This feasibility study examined the impact of a 13-week exercise intervention on tibial bone parameters in adolescents with DCD.Methods: Twenty-eight adolescents with DCD particip...

Background: There are no models for estimating risk of fracture in patients taking treatments for osteoporosis. Knowing a patient’s risk of fracture during treatment may help make future treatment decisions; therefore, the development of on-treatment fracture risk models is needed.Methods: To assess on-treatment fracture risk, the analysis included subjects who received denosumab (DMAb) 60 mg Q6 every 6 months for at least 1 year in either FREEDOM o...

Subject: To examine the relationship between calcification of the coronary arteries, coronary atherosclerosis and indicators of bone mineral density (BMD) among males with coronary heart disease (CHD).Materials and methods: Seventy-four males with documented CHD were examined. BMD was assessed by dual energy absorptiometry with T-criterion definition of the proximal femur and lumbar spine, coronarography, multispiral computed tomography with quantificati...

Objectives: We aimed to analyze bone mineralization in postmenopausal women of Southern Apulia and to evaluate the effect of obesity-related phenotypes as BMI ≥30 kg/m2, diabetes, hypertension and cardiovascular diseases.Methods: The PROF project is a population-based study on 3.356 subjects (40–99 years) analyzed by phalangeal quantitative ultrasound (QUS) to evaluate bone mineral status. A total of 2.756 postmenopausal women were ...

Background: Dual-energy X-ray absorptiometry (DEXA) is the gold standard used for measuring bone mineral density and such readings are currently used to predict osteoporosis and osteoporotic fractures. However, no similar prediction model has been developed to identify the age that a patient will become osteoporotic based on DEXA scanning.Objective: The aim of this study was to develop a mathematical model to determine the TTO based on two or more DEXA s...

Objectives: This study was designed to investigate the prevalence of low bone mass, the influence of amenorrhea on bone mineral density (BMD), and the cause of amenorrhea that provoke the severe low bone mass in premenopausal women.Materials and methods: One hundred and seventy one women diagnosed with amenorrhea in premenopausal women were included in this study. All patients underwent history taking, gynecological examination, and check serum hormone l...