Bone Abstracts

Background and methods: A specific skeletal complication in children with CKD is growth impairment. The effects of recombinant human growth hormone (rhGH) therapy on bone turnover and bone material quality are not well understood. Bone matrix mineralization density distribution (BMDD) as assessed by quantitative backscattered electron microscopy (qBEI) is an important determinant of bone material quality and reflects bone turnover (average tissue age) and mineralization kineti...

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EpiReumaPt is a cross-sectional, epidemiologic study to estimate the prevalence of rheumatic diseases in Portugal. Selected cases randomized from the 10 000 Portuguese subjects recruited are eventually observed by a rheumatologist. Portuguese and Spanish FRAX® tool were applied. The major osteoporotic (MOFR) and hip (HFR) fracture risk were calculated without DXA results.The FRAX tool has been developed by WHO to evaluate 10 years fracture risk. It ...

Although the optimal requirement of vitamin D for skeletal health in the general community remains uncertain, vitamin D deficiency impairs bone mineralisation, increases bone turnover, accelerates bone loss and increases fracture risk. Seasonal variation in the hip fracture incidenc, reported in several studies, supports a role for vitamin D deficiency in the epidemiology of hip fracture. We hypothesised that if the association is causal, then the amplitude of the seasonal var...

Objective: We investigated the effect of creatine administered in the diet for 10 weeks on bone turnover and bone quality in male Wistar rats.Methods: Rats were divided (after approval of Ethical committee 9814/2008–30 and 30793/2010–30) into four groups, ten animals in each group. G1 SLD-A group were fed a standard laboratory diet (SLD). G2 SLD-B group were fed SLD and 12 h before rats were sacrificed diet was removed. G3...

Objective: We investigated the effect of arginine administered for 10 weeks in diet on bone metabolism in male Wistar rats.Methods: Rats were divided (after approval of Ethical Committee 9814/2008-30 and 30793/2010-30) into four groups, ten animals in each group: G1 SLD-S group were fed a standard laboratory diet (SLD). G2 SLD-H group were fed SLD and 12 h before rats were sacrificed diet was removed. G3 ARG-S group was fed wit...

It is well known that thyroid hormone (TH) is essential for normal bone growth and development. However, the mechanisms by which TH regulates these processes are poorly understood. Recently, the sympathetic nervous system (SNS) was identified as a potent regulator of bone metabolism. In vivo studies by our group have shown that TH interacts with the SNS to regulate bone mass and structure, and that this interaction involves α2 adrenoceptor (α2-A...

Objectives: Postural balance and gait speed are risk factors for falls and hip fractures independent of bone mineral density (BMD). The standard risk assessment tool, FRAX, does however not include any estimate of fall risk. Identifying high-risk individuals correctly is be of great clinical importance why further improvement of FRAX would be clinically valuable. The primary aim of this study was to see if one-leg standing time, the maximum number of steps on a line or gait sp...

Children and adolescents with inflammatory bowel disease (IBD) have defects in bone mineral density (BMD) and bone structure that do not completely normalize with clinical remission.The objective of the study was to determine bone turnover marker (BTM) concentrations and factors behind altered bone metabolism in a case-control setting.We measured the bone formation marker PINP and bone resorption markers CTX and TRACP5b in 42 adole...

Introduction: In rheumatoid arthritis (RA) patients subclinical atherosclerosis and cardiovascular events (CV) occur more frequently and at younger ages than in the general population. Previous data suggest that heterogeneous plaques on USA are more unstable and frequently contain a higher amount of lipids and which make them hypoechoic and had higher potential for embolization and thrombosis. The aim of our work was to estimate the prevalence and the ultrasound morphology of ...