Bone Abstracts

Objective: To examine bone mineral density (BMD) at the femoral neck (FN) and lumbar spine (LS) in patients (pts) with early axial spondyloarthritis (axSpA).Methods: 73 pts (33 men and 40 women) with early axSpA were included in this study. Pts fulfilled ASAS criteria. Pts enrolled in the study had inflammatory back pain for < 5 years: mean disease duration 19.9±14.4 months. Mean age 28.3±6.4 years, mean BASDAI 4.1±1.9; mean ASDAS-CRP ...

Introduction: The patients with rheumatoid arthritis (RA) are less physically active than the general population. The aim of the study is to assess the effect of two exercise programs on the functional status of patients with early RA.Methods: Fifteen patients with early RA underwent ten high-intensity dynamic exercises using Enraf-Nonius gym for 45–60 min, including aerobic part (En-Cardio) and 18–20 muscle-strengthening exercises (En-Dynamic ...

Subject: To examine the relationship between calcification of the coronary arteries, coronary atherosclerosis and indicators of bone mineral density (BMD) among males with coronary heart disease (CHD).Materials and methods: Seventy-four males with documented CHD were examined. BMD was assessed by dual energy absorptiometry with T-criterion definition of the proximal femur and lumbar spine, coronarography, multispiral computed tomography with quantificati...

Objectives: Hypophosphatasia (HPP) is a rare metabolic disease caused by loss-of-function mutation(s) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene. Resultant low TNSALP leads to defective skeletal mineralization and diverse complications that may include poor growth, proximal muscle weakness, pain, and compromised physical function in children. Here, we describe the burden of HPP in patients <18 years old as assessed by two surveys specific to HPP symptomol...

Homozygous or compound heterozygous mutations in the RECQL4 helicase gene are responsible for 65% cases of Rothmund-Thomson syndrome (RTS-type II), a rare premature ageing syndrome. RTS-II patients exhibit poikiloderma and various kinds of bone abnormalities: short stature, congenital radial ray anomalies, bone microarchitecture defects, diffuse or localized osteoporosis and increased risk of osteosarcoma. Mutations in the RECQL4 gene are also responsible for...

Background: Hereditary pseudovitamin D-deficiency rickets, also known as vitamin D-dependent rickets type I, with an autosomal recessive inheritance, is caused by mutations in CYP27B1. It is characterized clinically by hypotonia, weakness, growth failure, and hypocalcemic seizures in early infancy. The patients also have hypocalcemia, radiologic findings typical of rickets, elevated serum parathyroid hormone concentrations, and generalized aminoaciduria. We present follow-up o...

The aim of this study was to estimate the structure of pain syndrome and reveal the presence of neuropathic pain component in patients suffering from the osteoporosis and low back pain.Material and methods: We have examined 107 patients aged 45–89 years (average age 68.1±1.2 years). Patients were divided into 2 groups: A – patients with osteoporosis (n=49), B – patients with low back pain (n=58). And according to age...

Objectives: Hypophosphatasia (HPP) is a rare metabolic disease caused by loss-of-function mutation(s) in the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). HPP in infants is characterized by poor skeletal mineralization, respiratory compromise, and a high risk of mortality. We previously reported improved mineralization and respiratory function in 15 patients enrolled in this second study of asfotase alfa, a bone-targeted recombinant human TNSALP, in infants a...

The aim of this study was to evaluate the bone mineral density (BMD), trabecular bone score (TBS) in the Ukrainian women with obesity.Materials and methods: 1025 women aged 40–89 years (mean age – 62.7±9.7 yrs; mean height – 161.4±6.2 cm; mean weight – 73.9±13.8 kg, body mass index – 28.4±5.1 kg/m2) were examined. The women were divided into the following groups depending on their body mass index: A...

Introduction: The recent studies show high prevalence of vitamin D deficiency and insufficiency all over the world. Vitamin D deficiency can cause serious problems such as rickets in children and osteomalacia in adults.The aim of the study was to determine the influence of vitamin D deficiency on bone mineral density.Methods: There were examined 304 children aged 10–18 years. The boys consisted 53%. The average age of boys was...