Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0003pp380 | Other diseases of bone and mineral metabolism | ECTS2014

TNSALP influences neurogenic differentiation by altering gene expression in SH-SY5Y cells

Graser Stephanie , Mentrup Birgit , Hofmann Christine , Schneider Doris , Jakob Franz

Hypophosphatasia (HPP) is a rare disease characterized by low enzymatic activity of tissue-nonspecific alkaline phosphatase (TNSALP) resulting in an accumulation of its endogenous substrates like pyridoxal phosphate (PLP) and inorganic pyrophosphate (PPi). The ectoenzyme plays an important role during bone mineralization and might contribute to proper function of kidney and muscle. Neurological symptoms of HPP like seizures, anxiety disorders and depression provide ...
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ba0006p057 | (1) | ICCBH2017

Zebrafish as a model for hypophosphatasia

Graser Stephanie , Liedtke Daniel , Geidner Barbara , Heppenstiel Yvonne , Jakob Franz , Klopocki Eva

Objectives: Hypophosphatasia (HPP) is a rare hereditary disease, leading to deficits in bone and tooth mineralization, muscular as well as neurological abnormalities due to decreased enzymatic activity of the tissue-nonspecific alkaline phosphatase (TNAP, encoded by the alpl gene). In this project, the zebrafish (Danio rerio) will be established as a new and valuable animal model for HPP research. Consequently, endogenous TNAP expression should be analyzed in different zebrafi...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0005cabs.oc2.3 | Oral Communications | ECTS2016

Cancer cell homing to the bone marrow is modulated by the mesenchymal stromal cell

Rossnagl Stephanie , Nakchbandi Inaam

Several cell types form the hematopoietic stem cell niche. These niches sometimes become hijacked by cancer cells, which may later form metastatic lesions. Our aim was therefore to characterize the bone marrow microenvironment to affect cancer cell homing to bone marrow.Pharmacologic modification consisting of PTH to stimulate the osteoblasts and zoledronic acid to prevent the increase in osteoclasts through PTH resulted in increased homing of cancer cel...
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ba0001oc6.4 | Mineralisation and energy metabolism | ECTS2013

Inhibition of PTH-induced vasorelaxation modulates its anabolic action

Gohin Stephanie , Chenu Chantal , Pitsillides Andrew , Arnett Timothy , Marenzana Massimo

The relationship between bone formation and blood flow is unclear. Recently, PTH was reported to activate production of nitric oxide (NO), a potent vasorelaxing agent, in endothelial cells and we and others have confirmed a strong vasorelaxing action of PTH in vivo in the mouse. Here, we tested the hypothesis that a potent NO synthase inhibitor (L-NAME: NG-nitro-L-arginine methyl ester) may alter the effect of intermittent PTH (iPTH) on b...
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ba0003pp319 | Osteoporosis: treatment | ECTS2014

Perceived vs objective knowledge in patients with osteoporosis

Miller Amanda , Thompson Kara , Cole Jenneth , Kaiser Stephanie

Previous studies have demonstrated that patients with osteoporosis (OP) have a poor understanding of their bone disease and that this negatively influences treatment decisions and medication compliance. The aim of this study is to determine if there is a discrepancy between perceived and objective disease knowledge (PK and OK, respectively) in patients with OP and whether this correlates with certain patient characteristics.Design and methods: After ethi...
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ba0004oc21 | (1) | ICCBH2015

Maternal vitamin D deficiency alters later skeletal responsiveness to mechanical loading in a model system

Borg Stephanie , Buckley Harriet , Nicholson Kirsty , Skerry Tim , Bishop Nick

Fractures in children are common; prospective cohort studies suggest narrower bones predispose to fracture. Early life events can influence later growth and development. Observational studies suggest children born to mothers with lower vitamin D levels during pregnancy have narrower bones. We investigated the effects of maternal vitamin D deficiency on offspring’s bones’ response to mechanical loading in a model system.C57BL/6 female mice (...
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ba0005cabs.oc3.2 | Oral Communications | ECTS2016

Osteoblasts inhibit the immune response against cancer

Rossnagl Stephanie , Kraft Sabrina , Sens Carla , Nakchbandi Inaam

Osteoblasts line the inner surface of the bone and are located in close proximity to the bone marrow, where hematopoiesis takes place. Osteoblasts produce several cytokines that affect various steps of hematopoiesis, and produce fibronectin isoforms that affect cell differentiation. Little is known however on whether osteoblasts modulate the immune response. Our aim was to evaluate the role of fibronectin originating from the osteoblasts on hematopoiesis and the immune respons...
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ba0005oc4.5 | Catabolism and metabolism | ECTS2016

Effects of glucagon-like peptide-1 receptor agonists on bone blow flow and architecture in diabetic mice

Pereira Marie , Gohin Stephanie , Cleasby Mark , Chenu Chantal

Type 2 diabetes mellitus prevalence increases with age and the disease predisposes to increased risk of fractures and skeletal complications. One possible contributor to skeletal weakening in diabetes is a decline in blood supply. We hypothesised that bone blood flow is impaired in diabetic mice and that chronic administration of glucagon-like peptide-1 receptor agonists (GLP-1RA) can increase blood flow to bone, thereby stimulating bone formation and improving bone architectu...
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ba0001pp471 | Other diseases of bone and mineral metabolism | ECTS2013

Long-term energy deficiency in mice induces bone alterations reversed by long-term recovery

Zgheib Sara , Lucas Stephanie , Mequinion Mathieu , Broux Odile , Leterme Damien , Hardouin Pierre , Viltart Odile , Chauveau Christophe

Anorexia nervosa (AN) a condition of profound undernutrition, is characterized by alterations in neuroendocrine and metabolic functions. Among the serious pathological consequences of this eating disorder, osteoporosis is often observed and persists after recovery, leading to a high fracture risk.To study particularly bone alterations and recovery, a long term mouse model has been developed. In this model named separation-based anorexia (SBA) – a ch...
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Bone Abstracts
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