Bone Abstracts

Introduction: In postmenopausal women with vertebral compression fractures (VCF) the mechanisms regulating healing processes and an anti-osteoporotic treatment are not completely clarified. The aim of this prospective study was the evaluation of bone turnover markers, bone mineral density and radiographic progression of one or more VCF during assumption of risedronate, strontium ranelate or teriparatide.Materials and methods: Women with recent osteoporot...

Objectives: Marfan syndrome (MFS) is a connective disorder caused by mutations in FBN1 gene which encodes the extracellular matrix protein fibrillin 1. Pathogenesis relies on a dysregulation of activated TGF-β. Cardiovascular, ocular and skeletal systems are involved with a variable expressivity. Findings evolve with age, making the diagnosis in children more difficult. Skeletal involvement includes disproportionate long bone overgrowth, scoliosis, and chest deformity. Al...

Objectives: Congenital adrenal hyperplasia (CAH) is a rare condition characterized by the inability of the adrenal gland to produce cortisol. The classical form is due to the deficit of 21-hydroxylase activity (21-OHD) and it accounts for 90–95% of all CAH cases. Treatment of CAH patients consists of life-long glucocorticoid therapy, which must be dosed carefully to avoid excessive or insufficient adrenal suppression. There are data showing low bone mineral density (BMD) ...

Introduction: Dual X-ray Absorptiometry (DXA) is currently the best technique available to evaluate bone mass, enabling the diagnosis of osteoporosis, the prediction of fracture risk and monitoring.Clinical good practices consider as preferred measuring sites the lumbar (L1–L4) and proximal femur (neck and total). The vertebral morphometry is a quantitative method for the diagnosis of vertebral fractures based on measuring vertebral heights.<p...

Objective: Dual-energy X-ray absorptiometry (DXA) is the most commonly used method for evaluating bone mineral density (BMD) in children and adolescents. An innovative echographic approach for osteoporosis diagnosis, directly applicable on both femoral neck and lumbar spine, has been recently introduced and clinically validated through single-center and multicenter studies in a adult population. This developed approach has been subsequently defined as Radiofrequency Echographi...

Reduced bone mineral density (BMD) has been reported to adversely affect health related quality of life (HRQoL) also in postmenopausal women without vertebral fracture. To date no data exist in literature about any possible influences of quantitative ultrasonography (QUS) on HRQoL. This study aimed to assess whether QUS parameters at calcaneous may be associated with HRQoL.In 1812 ambulatory postmenopausal women aged 60 years or over, referred by their f...

Thalassemia is a chronic anemia associate with high rates of osteoporosis. To determine how erythropoiesis leads to bone loss in thalassemia, we used the th3/+ thalassemia mouse to study the role of erythropoietin (EPO) and hematopoietic progenitors (HP), since they are both increased in thalassemia.Methods: Bone marrow mesenchymal stem cells (MSCs) cultures and MSC cocultures with various HP from wild type (wt) and th3/+ mice were diff...

Arterial stiffness or pulse wave velocity (PWV) is increasingly recognized as a strong predictor of future cardiovascular events and all cause mortality. Literature date indicate a relationship between vitamin D (25-OHD) deficiency and arterial stiffness in isolated systolic hypertension (ISH), but it is still unclear how 25-OHD deficiency may contribute to functional changes of the arterial wall in hypertensive patients. This study aimed to evaluate the relationships between ...

Objective: Low bone mass is a frequent and early complication of subjects with Rett syndrome. As a consequence of the low bone mass Rett girls are at an increased risk of fragility fractures. The frequent occurrence of osteopenia raises questions regarding the direct influence of MECP2 gene mutations on bone growth and attainment of peak bone mass. It is well known that other critical factors such as the use of anticonvulsant drugs, the presence of scoliosis, the nutrition sta...

Low bone mass is a frequent complication of subjects with Rett syndrome. It is well known that many factors such as the use of anticonvulsant drugs, the presence of scoliosis, the nutrition status, the low levels of 25OHD and the ambulatory impairment influence the attainment of peak bone mass in Rett subjects. This study aimed to investigate the long-term influences of mobility on bone status in girls with Rett syndromeIn 47 girls with Rett syndrome, se...