Bone Abstracts

Focal cortical thinning and loss of trabecular structure in the proximal femur is associated with hip fracture. We analysed clinical computed tomography (CT) scans in cases and controls to explore their contributions to hip fracture in women.We used cortical bone mapping (CBM) and statistical parametric mapping (SPM) after combining women with hip fracture from FEMCO and Prague Hip Joint in Trauma studies (n=138, 52 Trochanteric and 86 Femoral N...

Objectives: Clinicians practicing in long-term care (LTC) face unique challenges caring for frail elderly individuals including multiple co-morbidities, polypharmacy, and end of life care, and practice guidelines typically do not address this population. Guidance regarding the management of osteoporosis and fracture prevention in LTC, a high-risk population, is needed.Materials and methods: A survey of LTC physicians informed key questions and outcomes, ...

The objective of this investigation was to compare bone mineral density (BMD) attained from dual-energy X-ray DXA with speed of sound (SOS) data attained from a Beam-Med Omnisense multisite quantitative ultrasound (mQUS) in a large sample of randomly-selected community-based individuals from the Canadian Multicentre Osteoporosis Study (CaMOS). A total of 1177 men and 2949 women were assessed with mQUS at the distal radius, tibia, and phalanx sites as part of the Canadian Multi...

This investigation sought to assess the relationship between physical activity (PA) and estimated bone stiffness as assessed by multisite quantitative ultrasound (mQUS) in a large cohort. A total of 1177 men and 2949 women were assessed with mQUS (Beam-Med Omnisense quantitative ultrasound; Isreal) at the distal radius, tibia, and phalanx sites as part of the Canadian Multicentre Osteoporosis Study (clinical sites included Saskatoon, Calgary, Hamilton, Quebec City, Halifax and...

This investigation sought to assess the relationship between vitamin D and calcium intake and estimated bone stiffness as assessed by multisite quantitative ultrasound (mQUS) in a large cohort. A total of 1177 men and 2949 women were assessed with mQUS (Beam-Med Omnisense quantitative ultrasound; Isreal) at the distal radius, tibia, and phalanx sites as part of the Canadian Multicentre Osteoporosis Study (clinical sites included Saskatoon, Calgary, Hamilton, Quebec City, Halif...

Introduction: Giant cell tumour of the bone (GCTB) is a benign, locally aggressive tumour whose neoplastic stromal cells express receptor activator of nuclear factor kappa-B ligand (RANKL) and activate its receptor RANK on osteoclast-like giant cells. Denosumab (RANKL inhibitor) is an FDA/EMA approved treatment for GCTB in adults and ‘skeletally mature’ adolescents. Safety concerns include oversuppression of bone remodelling, with risk of osteonecrosis of the jaw [ON...

Vertebral fractures (VF) defined by morphometric analysis of spine radiographs are the most common complication of osteoporosis. Those that come to medical attention, with symptoms such as back pain and kyphosis are termed clinical vertebral fractures (CVF) and account for significant morbidity and mortality. Although much progress was made in identifying loci for bone mineral density, the genetic determinants of CVF remain unclear. Here we present the initial results from a g...

Introduction: Current Canadian clinical practice guidelines recommend the FRAX or Canadian Association of Radiologists and Osteoporosis Canada (CAROC) fracture risk assessment tools to report 10-year fracture risk in an individual. CAROC considers sex, age, BMD and previous fracture as risk factors. It is unknown whether one reporting system is more effective in helping general practitioners (GPs) identify individuals who should be recommended for pharmacological treatment. We...

Fibroblast growth factor-23 (FGF23) is a major regulator of phosphate metabolism often elevated in genetic hypophosphataemic disorders and in chronic kidney disease–bone mineral disorder (CKD–BMD). Recent studies have identified relationships between FGF23 and vitamin D.Objectives: To determine the relationship between vitamin D and FGF23 metabolism in CKD.Method: We used randomized samples from patient...

Objective: We aimed to investigate associations between early-life vitamin D status, mode of infant milk-feeding and bone outcomes at five years.Methods: Participants were from the prospective mother-infant SCOPE-BASELINE Birth Cohort Study. Serum 25 hydroxyvitamin D (25(OH)D) concentrations were quantified at 15 weeks gestation, in umbilical cord sera and at two and five years using a gold-standard CDC-accredited LCMS method. Whole-body bone mineral con...