Bone Abstracts

Advanced-stage prostate and breast cancer patients commonly develop bone metastases, accounting for significant clinical problems such as pain, fracture, immobility and death. Bone is comprised of diverse cell types that are potentially involved in metastatic progression. However, how cancer cells interact with these cells within the bone microenvironment to support their expansion and activity remains unclear. Recent data from our laboratory highlighted a novel feed-forward m...

Objectives: As children with confirmed type 1 Gaucher disease (inherited metabolic disorder) may have linear growth retardation, we evaluated linear growth over 2 years in children enrolled in the interventional study TKT034, in which patients receiving imiglucerase enzyme replacement therapy were switched to velaglucerase alfa.Methods: Trial TKT034 enrolled patients who were ≥2 years of age with type 1 Gaucher disease and stable clinical parameter...

Arrest defective 1 was originally identified as an acetyltransferase essential for the life-cycle progression in yeasts. Its human orthologue hARD1 has been known to express the enzymatic activity and to acetylate several targets such as HIF-1alpha, MLCK-1, and beta-catenin. Here, whether hARD1 takes part in pre-osteoblast differentiation toward calcium-deposing osteoblast was explored. ALP staining and alizalin red S staining showed that osteoblast differentiation was negativ...

Background: Hypophosphatasia (HPP) is a rare skeletal disease characterized by defective bone and teeth mineralization and the deficiency of tissue non-specific alkaline phosphatase activity. This disorder is caused by mutations in the ALPL gene, which encodes TNAP. The clinical presentation of HPP varies greatly, ranging from stillbirth without bone mineralization (perinatal form) to findings in later life, such as delayed walking, short stature, skeletal deformities, bone pa...

Objectives: There are some studies that evaluated changes of bone marrow density (BMD) and re-fracture after zoledronic acid injection. However, there is no study that showed about the fracture on all of the body, fracture healing, and improvement of clinical symptom after zoledronic acid injection. In this study, authors evaluated the 1 year BMD change, changes of lumbar pain in lumbar spine fractures, effects on fracture healing, re-fracture and additional fracture on other ...

Introduction: Advancing age is associated with decline in bone and muscle mass and quality. Sarcopenia, one of Geriatric syndromes, is defined as the age-associated loss of skeletal muscle mass and function resulting in disability, poor QOL and death.Objective: To evaluate the prevalence of sarcopenia and its association with osteopenia/osteoporosis in Korean PMW.Materials and methods: Subjects: total 225 Korean PMW over 50 years w...

Objectives: There are some studies that evaluated changes of bone marrow density (BMD) and re-fracture after zoledronic acid injection. However, there is no study that showed about the fracture on all of the body, fracture healing, and improvement of clinical symptom after zoledronic acid injection. In this study, authors evaluated the 1-year BMD change, changes of lumbar pain in lumbar spine fractures, effects on fracture healing, re-fracture and additional fracture on other ...

In bone marrow, bone marrow stromal cells (BMSCs) have the capacity to differentiate into osteoblasts and adipocytes. Onset of osteoporosis with age stems in part from the enhanced bone marrow adipogenesis that represses osteogenesis. In this study, we demonstrate that disruption of nuclear factor I-C (NFI-C) impairs osteoblast differentiation and bone formation, and increases bone marrow adipocytes. Interestingly, NFI-C controls postnatal bone formation but does not influence...

Paget’s disease of bone is a condition where the process of bone remodeling is disrupted; Its primary event is an increased bone resorption followed by a subsequent reactive bone formation. The disease is most common in central Europe, the United Kingdom, Australia, and New Zealand. It is also found, though with lower incidence, in southern Europe, Scandinavia, and the United States. It is extremely rare in East Asian countries, especially in Korea, Japan, China, the Midd...

Reduced availability of oxygen, i.e. hypoxia, could occur during disuse, bone development, and fracture. Cartilage tissue is avascular in nature and the microenvironment of cartilage is hypoxic. Hypoxic regulation of gene expression generally involves activation of the hypoxia-inducible factor (HIF) transcription pathway. Receptor activator of nuclear factor-kappaB ligand (RANKL) is an osteoblast/stromal cell derived essential factor for osteoclastogenesis. Hypoxia-induced enh...