Bone Abstracts

Purpose: Multipotent stromal cells (MSC)-based regenerative strategy is promising for the repair of cartilage, which is an avascular tissue in which cells experience hypoxia. Hypoxia is known to promote the early chondrogenic differentiation of MSC. Therefore, the aim of our study was to determine whether low oxygen tension could be used to enhance the regenerative potential of MSC for cartilage repair.Methods: MSC from rabbits or human adipose tissues (...

BMD alone is not sufficient to predict the fracture risk for an individual. Others parameters, such as microarchitecture play a key role in bone fragility. Several cross-sectional studies have shown the ability of TBS to discriminate fractured from healthy subjects in European populations. The aim of our study is to assess the ability of TBS, evaluated at the lumbar spine, to discriminate subjects with and without fracture in a large white US population....

Bone loading is a primary determinant of bone strength in later childhood and adulthood. Our understanding of how mechanical stimuli generated by foetal kicking and movements impact skeletal development is still limited. Many studies suggest that a sufficient and balanced supply of energy, proteins, vitamins, calcium, phosphorus, and other nutrients is an essential prerequisite for normal bone development. However, only few studies highlight the contribution of the biomechanic...

Adverse reactions to bisphosphonates are common and thus, most of them are predictable side effects to the drug. Allergic reactions or skin reactions of any type or severity associated with bisphosphonates have been scarcely described in the literature. Allergic and skin reactions to bisphosphonates have been estimated to occur in less than 1% of patients. The mechanism of these reactions is unknown, although it is presumed to be IgE mediated. All of the bisphosphonates share ...

The aim of the study is to compare the performance of FRAX vs TBS adjusted FRAX using Leslie B et al.1 method to better identify women at high fracture risk. The OsteoLaus cohort (1500 women 50–80 years living in Lausanne, CH) started in 2010. CRF for OP, FRAX, spine and hip BMD, VFA by DXA and TBS were recorded. Sensitivity and specificity in regard to vertebral fracture grade 2 and 3 has been calculated. Net reclassification improvement (NRI) had als...

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Although estrogen deficiency has been considered for a long time as the main factor leading to osteoporosis (OP), several lines of evidence highlight the role of oxidative stress increase with age as a key factor in this pathology. Autophagy acts as a central mechanism allowing damaged macromolecules and organelles to be degraded and recycled, such as mitochondria, the main source of reactive oxygen species (ROS). Recent publications have shown that autophagy is a new actor in...

Autotaxin (ATX) is a secreted protein produced by various tissues in the body including the liver, adipose tissue and bone. Autotaxin (ATX) is an enzyme with a phospholipase D activity responsible for cleavage of lysophosphatidyl-choline (LPC) in lysophosphatidic acid (LPA). LPA is a bio phospholipid, which acts as a growth factor, affecting proliferation, differentiation, and migration. It has been shown that the biological effect of LPA could be the direct consequence of loc...

: Hyperphosphatemic tumoral calcinosis (HTC) is a rare autosomal recessive metabolic disorder characterized by ectopic calcifications due to progressive deposition of basic calcium phosphate crystals in soft tissues. The biochemical hallmark of HTC is hyperphosphatemia caused by increased renal absorption of phosphate due to loss-of-function mutations in three genes: in the fibroblast growth factor-23 gene (FGF23) coding for a potent phosphaturic protein, in GALNT3, g...

We investigated the ability of microRNAs to regulate osteoblast differentiation by controlling distinct aspects of the differentiation process. We have identified by microRNAs microarray a set of miRNAs that are differentially regulated during differentiation of the two osteoblast cell lines MC3T3-E1 and C3H10T1/2. We focused on miR-468 that is a potential regulator of Runx2.In our microarray analysis miR-468 was expressed at a high level and was strongl...