Bone Abstracts

The purpose of this study was to analyze the influence of diet supplemented with hydrosoluble soy extract – HSE in bone mass of male and healthy Wistar rats. Sixteen (16) 30 days old animals were kept in controlled conditions with light/dark cicle and fed with commercial food and filtered water. Randomized into two groups: control group received 500 ml of water and 300 g of food, daily; supplemented group S, in addition of water and food, they also received 500 ml of soy ...

In recent years, latex membrane synthesized from natural latex extracted from rubber tree Hevea brasiliensis, has been studied as an important biomaterial to assist in tissue regeneration process, since it has ability to induce neovascularization and tissue proliferation, and is a low-cost and easy material handling. The aim of this study was to evaluate mechanical properties of bones after treatment with natural latex membrane in bone defects created in the tibiae of...

In this study, the effect of food restriction of 30% in calorie intake on femurs of rats of different ages was investigated. Male Rattus novegicus albinus rats, Holtzman lineage, aged 38 days, 4 and 16 months were used. The animals were divided into six groups (n=8–10 per group), three being control groups (C38, C4 and C16) and three groups on restricted diet (R38, R4 on R16). The restricted animals were submitted to food restriction of 30% being fed wit...

Osteoclast presents a central role in several inflammatory diseases that are associated to bone destruction. This condition results from increased osteoclastic bone resorption and/or decreased bone formation. Fluoride (F) is widely consumed in the drinking water due to its anticariogenic effect and has been shown to modulate in vivo bone metabolism in a strain-specific dependent manner. It enhances bone formation in 129P3/J mice but not in A/J mice. However, its effec...

The childhood is an important period for bone mass acquisition, and this tissue may be influenced by the nutritional status. However, the relation between the nutritional status and the bone parameters of quantitative ultrasound (QUS) remains unclear. The aim of this study was to verify the influence of nutritional status on bone mass assessed by QUS in male children from 7 to 10 years old. The sample consisted of 461 Brazilians pre-pubertal schoolchildren (8.30±1.13 year...

In order to examine metabolic and biophysical parameters arising from obesity, male rats were given to drinking 30% sucrose (p/v) for 8 weeks. During the experimental period, animals in the control group (C) consumed higher amounts of food and water, but the body mass was smaller than the group receiving sucrose (S). In this group, the caloric load given to the animals for eight weeks resulted in increased energy consumption, in glycemia and in plasma leptin and abdominal fat....

The proper healing of bone defects requires a bone graft or bone substitute and synthetic materials have been developed as alternatives to autografts and allografts. Poly(DL-lactic-co-glycolic acid) (PLGA) is a synthetic polymer widely used for bone healing because of its biocompatibility and biodegradability. PLGA scaffolds have also been used in drug delivery devices, such as in combination with simvastatin, to stimulate bone growth. In this work, we examined ...

Constant remodeling of extracellular matrix (ECM) is a hallmark during physiological conditions, such as stem cell differentiation, embryogenesis and tissue repair. Matrix metalloproteinases (MMP) play a key role in these processes. MMPs, MMP-activator (EMMPRIN/CD147) and MMP-inhibitors (TIMPs and RECK) are responsible for bone matrix remodeling and, probably, determinate the level of its turnover. Mesenchymal stem cells derived from dental pulp are multipotent and have the ca...

Background: 3M syndrome is a primordial growth disorder caused by mutations in CUL7, OBSL1 or CCDC8. Affected individuals have severe short stature for which growth hormone (GH) therapy may have a role1. We present a 10-year-old girl from Sri Lanka with 3M syndrome-2 due to a mutation in OBSL1 gene, with good short-term response to growth hormone therapy.Presenting Problem: The only child of second-degree consanguineous parents, both themselve...

Several environmental and genetic factors are determinant, also including sex, hormonal, ethnics, nutritional and lifestyle, may interferer on bone mass of children. However, the pediatric studies that approach the socioeconomic status and the quantitative ultrasound parameters (QUS) are scarce. The aim of this study was to compare the socioeconomic status on bone mass assessed by QUS in boys from 7 to 15 years old. In this cross-sectional study, were evaluated 520 Brazilian b...