Bone Abstracts

Context: Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels.Aims: To examine the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men.Methods and material: We examined 162 me...

Introduction: Dual X-ray Absorptiometry (DXA) is currently the best technique available to evaluate bone mass, enabling the diagnosis of osteoporosis, the prediction of fracture risk and monitoring.Clinical good practices consider as preferred measuring sites the lumbar (L1–L4) and proximal femur (neck and total). The vertebral morphometry is a quantitative method for the diagnosis of vertebral fractures based on measuring vertebral heights.<p...

The exposition of shift workers to light at night supresses the melatonin (ME) production. ME supression may contribute to the development of osteoporosis, which can be prevented and treated by resistance exercise (RE). This study evaluated the effect of ME release supression by pineal gland (pinealectomy) and the RE on rats tibiae morphology, mineral quantification and mechanical parameters. The project was approved by the local ethics committee (protocol 2014-00939). Fourty ...

Aim: The aim of the study was to evaluate the usefulness of the fracture risk evaluated through the FRAX® model based only on the clinical risk factors as a screening tool for identify the target population for treatment in osteoporosis.Materials and methods: Two hundred and seventy-six postmenopausal women treatment naive referred to two different endocrinology departments for osteoporosis between 2009 and 2011 were evaluated. The FRAX® model ...

We recently observed an increased risk for vertebral fractures (VF) in a randomized controlled trial comparing the analgesic effect of vertebroplasty (VP) vs conservative treatment (CT) in symptomatic VF. The aim of the present study was to evaluate the risk factors related to the development of VF after VP in these patients.Methods and results: We evaluated risk factors including age, gender, bone mineral density, the number, type and severity of verteb...

Severe generalised recessive dystrophic epidermolysis bullosa (RDEB) is a rare disorder resulting from loss of function mutations in the type VII collagen gene (COL7A1). Although RDEB is characterised by severe skin blistering and erosions following minor mechanical trauma, it is a multisystem disorder with pubertal delay and low bone mass as part of the many complications.Children with RDEB have been described as having inadequate gains in bone...

The autophagy protein LC3 is necessary for bone resorption by osteoclasts, although it has been suggested that this may be through a novel, autophagy-independent process, by promoting lysosomal fusion at the ruffled border (RB). This process would be analogous to LC3-associated phagocytosis (LAP), in which LC3 is acquired by phagosomes through an autophagy-independent process, and controls phagosome maturation by promoting fusion with lysosomes. We have investigated this possi...

Background: Previous TBS studies in type 2 diabetes have suggested a deterioration of bone microarquitecture that could be related to a higher risk of fractures. However, there are no information in liver transplantation (LT) patients with new-onset diabetes after transplantation (NODAT).Our aim was to investigate TBS in LT patients and the influence of NODAT in these patients. Also, we investigated the relationship between TBS and body composition param...

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Objectives: This cross-sectional study was done in order to assess the prevalence and determinants of vitamin D deficiency in children taking in account the following parameters: children’s age, season, geographic region and ethnicity.Methods: A cross-sectional prospective study was conducted in Israeli children aged 0–18 from Meuhedet Health Services during the year of 2016 in primary care pediatric clinics throughout all different geographic ...