Bone Abstracts

Objective: To define, by expert consensus, the criteria for the application of a Treat-to-Target (T2T) strategy in osteoporosis, in Spain, and to assess the adequacy of current treatments for it.Material and methods: Six Spanish experts in osteoporosis formed the Scientific Committee that led the project and designed the questionnaire used in two Delphi rounds. The 24 items included in the questionnaire assessed the experts’ wish (W) and prognosis (...

Objective: To define, by expert consensus, the criteria for the application of a Treat-to-Target (T2T) strategy in osteoporosis, in Spain, and to assess the adequacy of current treatments for it.Material and methods: Six Spanish experts in osteoporosis formed the Scientific Committee that led the project and designed the questionnaire used in two Delphi rounds. The 24 items included in the questionnaire assessed the experts’ wish (W) and prognosis (...

Introduction: Gorham disease (GD), also known as Gorham–Stout syndrome, massive osteolysis or disappearing bone disease, is a very rare disease characterized by spontaneous and progressive osteolysis of one or more bones. Its prognosis is highly variable and unpredictable, ranging from minimal disability to death, due to involvement of vital structures, such as the vertebral column and rib cage. Osteoclasts hyperactivity has been suggested as potential pathogenetic abnorm...

Pioglitazone is a drug of the thiazolidinedione (TZD) class used to treat type 2 diabetes mellitus. TZD is an agonist of peroxisome proliferator-activated receptor γ (PPAR-γ) that improves insulin sensitivity, glucose and lipid metabolism and inflammation. However, TZD induces bone marrow adiposity with suppression of osteogenesis, that could contribute to bone loss and osteoporotic fractures. β-Cryptoxanthin is a carotenoid with antioxidant properties abundant ...

Long-term use of pharmacological treatments of osteoporosis is currently a controversial subject within the scientific community.The aim of this work was to study the effects produced by a preventive long duration treatment of strontium ranelate and zoledronic acid on bone mass and remodelling when they are administered to ovariectomized rats.Sixty female albino Wistar rats were divided into four groups (n=15): SHAM group ...

Denosumab (DNMB) is an effective treatment for osteoporosis with antiresorptive effect that has demonstrated to increase the bone mass and reduces the incidence of both vertebral and nonvertebral fractures in randomized controlled trials (RCTs).Objectives: To confirm that this drug is actually effective in our experience into daily clinical practice as well.Material and methods: 30 postmenopausal women, mean age 71 years (r</em...

Introduction and objectives: There is an increasing interest in knowing the factors related to the wear particle-induced disease in total hip replacement (THR), after long-term follow up. Numerous studies have analyzed the development and the destruction patterns of the osteolisis. The objectives of this study were to determine the factors associated with major frequency and severity of this disease and their influence in the osteolytic progression pattern, using magnetic reso...

Introduction: Age-related bone diseases, such as osteoarthritis (OA) and osteoporosis (OP), are strongly associated with sarcopenia and muscle fiber atrophy. Potential mechanisms involved in the reduction of skeletal muscle mass during sarcopenia converge on the failure of satellite cells in replacing and repairing damaged muscle fibers. Myostatin and bone morphogenetic proteins (BMPs) are molecules able to regulate muscle mass homeostasis by activating satellite stem cells [4...

Osteoarthritis and osteoporosis are two elderly conditions characterized by two different pathophysiological mechanisms. In patients with chronic kidney disease (CKD), there is a metabolic impairment of the muscular-skeletal tissue. The aim of our study is to evaluate the biochemical and morphostructural alterations in different states of CKD in patients with osteoarthritis or hip fracture.We evaluated all patients undergoing hip replacement surgery from...

Introduction: Myostatin (growth differentiation factor 8, GDF-8) has an important role in the regulation of muscle mass, and mice lacking the myostatin gene show a generalized increase in bone density and strength. Type 2 diabetes subjects have an increased risk of fragility fractures despite of higher bone mass. Taking into account the myostatin influence in bone strength a better understanding of myostatin actions in type 2 diabetes is of interest.Obje...